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个人简介

教育背景: 1995年9月-2000年7月,复旦大学上海医学院,临床医学系,医学学士 2000年9月 -2005年7月,中国医学科学院基础医学研究所,生物化学与分子生物学系,理学博士 工作经历: 2005年8月- 2014年8月,中国医学科学院药物研究所,药理系,助理研究员 2014年9月-,中国医学科学院药物研究所,药理系,副研究员

研究领域

主要从事肿瘤发生、发展的分子及细胞机制研究。

近期论文

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1. Hua F#, Li K#, Yu JJ#, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW* TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradation functions. Nature Commun., 2015, 6:7951, doi: 10.1038/ncomms8951. (IF: 11.47) 2. Hua F, Li K, Yu JJ, Hu ZW* The TRIB3-SQSTM1 interaction mediates metabolic stress-promoted tumorigenesis and progression via suppressing autophagic and proteasomal degradation. Autophagy, 2015, 11(10): 1929-1931 (IF: 11.753) 3. Hua F, Hu ZW*. TRIB3-P62 interaction, diabetes and autophagy. Oncotarget. 2015 doi: 10.18632/oncotarget.6108. (IF: 6.359) 4. Hua F#, Shi MJ#, Zhu XL#, Li M, Wang HX, Yu XM, Li Y, Zhu CJ. Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: An insight into the efflux-metabolism alliance. Biochem Pharmacol. 2015, 98: 224-230 (IF: 5.009) 5. Yu JM#, Sun W#, Hua F, Xie J, Lin H, Zhou DD, Hu ZW. BCL6 induces EMT by promoting the ZEB1-mediated transcription repression of E-cadherin in breast cancer cells. Cancer Lett. 365: 190-200, 2015. (IF: 5.621) 6. Li K#, Lv XX#, Hua F, Lin H, Sun W, Cao WB, Fu XM, Xie J, Yu JJ, Li Z, Liu H, Han MZ, Hu ZW*, Targeting acute myeloid leukemia with a proapoptotic peptide conjugated to a toll-like receptor 2-mediated cell-penetrating peptide. Intl J Cancer, 134: 692-702, 2014. (IF: 5.085) 7. Lin H, Liu XB, JJ Yu, Hua F, Hu ZW*. Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. PLoS One, 8:e74130, 2013 (IF: 3.534) 8. Wang ZY, Lin H, Hua F and Hu ZW*. Repairing DNA damage by XRCC6/KU70 reverses TLR4-deficiency-worsened HCC development via restoring senescence and autophagic flux. Autophagy, 9:925-7, 2013 (IF: 11.423) 9. Wang ZY, Yan J, Lin H, Hua F, Wang XX, Liu H, Lv XX, Yu JJ, Mi S, Wang JP, Hu ZW*. TLR4 activity protects against hepatocellular tumorigenesis and progression via regulating the expression of DNA repair protein Ku70. Hepatology, 57:1869-81, 2013 (IF: 11.19 ) 10. Liu H, Mi S, Li Z, Hua F and Hu ZW*. Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells. Autophagy, 9:730-42, 2013. (IF: 11.423) 11. Lin H, Yan J, Wang ZY, Hua F, Yu JJ, Sun W, Li K, Liu H, Yang HZ, Lv Q, Xue JF, and Hu ZW*. Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in toll-like receptor 2-deficient mouse model. Hepatology, 57:171-182, 2013. (IF: 11.19 ) 12. Lin H, Hua F, and Hu ZW*. Autophagic flux, supported by Toll-like receptor 2 activity, defends against the carcinogenesis and progression of hepatocellular carcinoma. Autophagy, 8:1859-61, 2012. (IF: 12.042 ) 13. Lv Q, Wang W, Xue JF, Hua F, Mu R, Lin H, Yan J, Lv XX, Chen XG, Hu ZW*. DEDD interacts with class III PI-3-kinase to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer. Cancer Res, 72: 3238-50, 2012. (IF: 8.65) 14. Lv Q, Hua F, and Hu ZW*. DEDD, a novel tumor repressor reverses epithelial-mesenchymal transition by activating selective autophagy. Autophagy, 8:12-14, 2012. (IF: 12.042 ) 15. Sun W, Xie J, Lin H, Mi S, Li Z, Hua F, and Hu ZW*. A combined strategy improves the solubility of aggregation-prone single-chain variable fragment antibodies. Protein Expr Purif, 83:21-29, 2012. (IF: 1.429 ) 16. Zhu CJ*, Wang QQ, Zhou JL, Liu HZ, Hua F, Yang HZ, and Hu ZW*. The mineralocorticoid receptor-p38MAPK-NFκB or ERK-Sp1 signal pathways mediate aldosterone-stimulated inflammatory and profibrotic responses in rat vascular smooth muscle cells. Acta Pharmacol Sin, 33:873-878, 2012. (IF: 2.354) 17. Yan J#, Hua F#, Liu HZ, Yang HZ, and Hu ZW*. Blocking TLR2 and activating TLR9 induce a synergistic efficacy against pulmonary tumor metastasis. Acta Pharmacol Sin. 33:503-512, 2012. (IF: 2.354) 18. Yang HZ#, Wang JP#, Mi S, Liu HZ, Cui B, Yan HM, Yan J, Li Z, Liu H, Hua F., Lu W, and Hu ZW*. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol, 180: 275-292, 2012. (IF: 4.522) 19. Hua F#, Mu R#, Liu JW, Xue JF, Wang ZY, Lin H, Yang HZ, Chen XG, and Hu ZW*. TRB3 interacts with SMAD3 promoting tumor cell migration and invasion. J Cell Sci, 124: 3235-3246, 2011. (IF: 6.111) 20. Xue JF#, Hua F, Lv Q, Lin H, Wang ZY, Yan J, Liu JW, Lv XX, Yang HZ, and Hu ZW*. DEDD negatively regulates transforming growth factor-beta1 signaling by interacting with Smad3. FEBS letters, 584: 3028-3034, 2010. (IF: 3.538)

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