朱蕾蕾 - 中国科学院天津工业生物技术研究所 -

个人简介

教育经历 2001.09-2005.06，中国，江南大学，生物工程，学士学位 2005.09-2007.06，中国，江南大学，生物化工，硕士学位 2007.07-2009.06，德国，不来梅雅各布大学（Jacobs University Bremen），生物技术，博士学习 2009.07-2010.09，德国，亚琛工业大学（RWTH Aachen University），生物技术，博士学位工作经历 2011.01-2016.07，德国，亚琛工业大学（RWTH Aachen University），研究小组组长（subgroup leader） 2016.08-至今，天津工业生物技术研究所，蛋白质定向进化研究组组长

研究领域

发展酶蛋白的定向进化和高通量筛选技术，借助计算机辅助设计等蛋白质分子改造的手段创制高性能的工业酶和蛋白质，结合生物催化和合成生物学手段，推动一碳化合物资源化利用、塑料的生物降解及工业菌株的高效创制等

近期论文

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Ren P., Tan Z., Zhou Y., Tang H., Xu P., Liu H.*, Zhu L*. Biocatalytic CO2 fixation initiates selective oxidative cracking of 1-naphthol under ambient conditions. Green Chemistry,2022,DOI:10.1039/D2GC01226J. Li T., Tan Z., Tang Z., Liu P., Liu H.*, Zhu L.*, Ma Y. One-pot chemoenzymatic synthesis of glycolic acid from formaldehyde. Green Chemistry,2022,DOI: 10.1039/D2GC00688J. Cai T.#, Sun H.#, Qiao J.#, Zhu L.#, Zhang F., Zhang J., Tang Z., Wei X., Yang J., Yuan Q., Wang W., Yang X., Chu H., Wang Q., You C., Ma H., Sun Y., Li Y., Li C., Jiang H., Wang Q., Ma Y. Cell-free chemoenzymatic starch synthesis from carbon dioxide. Science,2021,373,1523-1527.(共同第一) Guo W., Yang J., Huang T., Liu D., Liu Q., Li J., Sun W., Wang X., Zhu L.*, Tian* C. Synergistic effects of multiple enzymes from industrial Aspergillus niger strain O1 on starch saccharification. Biotechnology for Biofuels,2021, 14:225. Nie Z. #, Liu P.#, Wang Y., Guo X., Tan, Z., Shen J., Tang Z., Sun J., Zheng P. *, Zhu L. * Directed evolution and rational design of mechanosensitive channel MscCG2 for improved glutamate excretion efficiency. Journal of Agricultural and Food Chemistry.2021,69,51,15660-15669. Yang J., Tu R., Yuan H., Wang Q.*, Zhu L.* Recent advances in droplet microfluidics for enzyme and cell factory engineering. Critical Reviews in Biotechnology,2021,41,7,1023-1045. Shi L., Liu H., Gao S., Weng Y.*, Zhu L.*. Enhanced extracellular production of IsPETase in Escherichia coli via engineering of the pelB signal peptide. Journal of Agricultural and Food Chemistry.2021,69(7),2245-2252 (ACS Editors’ Choice). Li T., Tang Z., Wei H., Tan Z., Liu P., Li J., Zheng Y., Lin J., Liu W., Jiang H., Liu H.*, Zhu L.*, Ma Y. Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediate. Green Chemistry, 2020, 22, 6809-6814. Cheng C., Haider J., Liu P., Yang J., Tan Z., Huang T., Lin J., Jiang M.,* Liu H.*, Zhu L.*. Engineered LPMO significantly boosting cellulase-catalyzed depolymerization of cellulose. Journal of Agricultural and Food Chemistry. 2020, 68, 15257-15266. Cheng F., Yang J., Schwaneberg U., Zhu L.*. Rational surface engineering of an arginine deiminase (an antitumor enzyme) for increased PEGylation efficiency. Biotechnology and Bioengineering, 2019, 116(9), 2156-2166. Cheng F., Yang J., Bocola M., Schwaneberg U., Zhu L.*. Loop engineering reveals the importance of active-site-decorating loops and gating residue in substrate affinity modulation of arginine deiminase (an anti-tumor enzyme).Biochemical and Biophysical Research Communication. 2018, 499(2), 233-238. Frauenkron-Machedjou V. J., Fulton A., Zhao J., Weber L., Jaege K. E. r, Schwaneberg U., and Zhu L.*. Exploring the full natural diversity of single amino acid exchange reveals that 40-60% of BSLA positions improve organic solvents resistance. Bioresource and Bioprocessing, 2018, 5:2. Markel U.#, Zhu L.#, Frauenkron-Machedjou V. Zhao J., J., Bocola M., Davari M. D., Jaeger K.E., Schwaneberg U. Are Directed evolution approaches efficient in exploring nature’s potential to stabilize a lipase in organic cosolvents? Catalysts, 2017, 7(5), 142. Charan H., Glebe U., Anand D., Kinzel J., Zhu L., Bocola M., Garakani T. M., Schwaneberg U., Boeker A. Nano-thin walled micro-compartments from transmembrane protein-polymer conjugates. Soft Matter. 2017, 13(15):2866-2875. Charan H., Kinzel J., Glebe U., Anand D., Garakani T. M., Zhu L., Bocola M., Schwaneberg U., Boeker A. Grafting PNIPAAm from β-barrel shaped transmembrane nanopores. Biomaterials. 2016,107:115-23. Cheng F.#, Zhu L.#, Schwaneberg U. Directed evolution 2.0: improving and deciphering enzyme properties. Chemical Communication, 2015,51(48):9760-9772. Cheng F., Kardashliev T., Pitzler C., Shehzad A, Lue H., Bernhagen J, Zhu L.*, Schwaneberg U*. A competitive flow cytometry screening system for directed evolution of therapeutic enzyme. ACS Synthetic Biology, 2015, 4 (7), 768-775. Zhu L., Cheng F., Piatkowski V. and Schwaneberg U.. Protein engineering of the antitumor enzyme PpADI for improved thermal resistance. ChemBioChem, 2014, 24, 15(2), 276-283. Hybrid ruthenium ROMP catalysts based on an engineered variant of β-barrel protein FhuA ΔCVF(tev): effect of spacer length. Sauer D. F., Bocola M., Broglia C., Arlt M., Zhu L., Brocker M., Schwaneberg U., Okuda J. Chemistry-An Asian Journal. 2015,10(1):177-82. Cheng F., Zhu L.*, Lue H., Bernhagen J, Schwaneberg U*. Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas. Applied Microbiology and Biotechnology, 2014, 99(3):1237-1247.