赵登高 - 五邑大学 - 生物科技与大健康学院

个人简介

赵登高，男，博士，讲师。主要从事天然产物全合成和结构修饰，以及新型抗肿瘤和抗炎化合物的开发。教育经历 2008/09--2013/06，兰州大学，有机化学，博士 2001/09--2005/06，兰州大学，化学，学士工作经历 2013/07-2016/05，广东工业大学，轻工化工学院，博士后 2016/06-至今，五邑大学，生物科技与大健康学院，从事教学和科研工作讲授课程农用化学品科研项目以微管蛋白和VEGF-R2为双靶点的新型血管靶向药物的设计、合成与构效关系研究，国家自然科学基金青年基金项目，2015.1.1–2017.12.31。

研究领域

天然产物全合成、结构修饰，以及新型抗肿瘤和抗炎化合物的开发

近期论文

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[1]Deng-GaoZhao,JianJunChen,Ya-RongDu,Ya-XiongChen,Yan-YanMa,KunGao,Bu-RongHu.SynthesisandStructure−ActivityRelationshipsofN-Methyl-5,6,7-trimethoxylindolesasNovelAntimitoticandVascularDisruptingAgents.JournalofMedicinalChemistry2013,56,1467-1477. [2]Deng-GaoZhao,Yan-YanMa,WeiPeng,Ai-YuZhou,YuZhang,ZhiyunDu,andKunZhang.TotalsynthesisandcytotoxicactivitiesoflongamideB,longamideBmethylester,hanishin,andtheiranalogues.Bioorganic&MedicinalChemistryLetter,2016,26,6–8. [3]WeiPeng,Yan-YanMa,KunZhang,Ai-YuZhou,YuZhang,HuaqianWang,ZhiyunDu,Deng-GaoZhao.Synthesisandbiologicalevaluationofnovelresveratrol-NSAIDderivativesasanti-inflammatoryagents.Chem.Pharm.Bull.2016,64,609–615. [4]Deng-GaoZhao,Ai-YuZhou,ZhiyunDu,YuZhang,KunZhang,Yan-YanMa.Coumarinswithα-glucosidaseandα-amylaseinhibitoryactivitiesfromtheflowerofEdgeworthiagardneri.Fitoterapia,2015,107,122–127. [5]Yan-YanMa,Deng-GaoZhao,Ai-YuZhou,YuZhang,ZhiyunDu,andKunZhang.α‑GlucosidaseInhibitionandAntihyperglycemicActivityofPhenolicsfromtheFlowersofEdgeworthiagardneri.JournalofAgriculturealandFoodChemistry,2015,63,8162–8169. [6]Yan-YanMa,Deng-GaoZhao,YaLi,Jian-JunChen,JunZeng,Qian-QianZhao,KunGao.CytotoxictriterpeneswithdiverseskeletonsfromAmooratsangii,PhytochemistryLetters,2016,15,251-255. [7]Yan-YanMa,Deng-GaoZhao,KunGao.StructuralInvestigationandBiologicalActivityofSesquiterpeneLactonesfromtheTraditionalChineseHerb:Inularacemosa.JournalofNaturalProducts2013,76,564-570. [8]Yan-YanMa,Deng-GaoZhao,YingZhai,YaLi,KunGao.TrinorsesquiterpenoidsfromInularacemosa.PhytochemistryLetters2013,6,645-648. [9]JieZhao,Huan-XingDing,Deng-GaoZhao,Chun-MingWang,KunGao.Isolation,modificationandcytotoxicevaluationofflavonoidsfromRhododendronhainanense.JournalofPharmacyandPharmacology2012,64,1785-1792.