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博士,动物营养与饲料科学专业教授,博士生导师,国家杰出青年基金获得者,浙江大学学术委员会委员,动物科学学院院长 教育背景与工作简历 1981.09-1985.07浙江工商大学(原杭州商学院)食品系1985年7月获学士学位 1985.08-1988.09安庆市商业局和安徽省商业厅从事食品营养与卫生检验 1988.09-1991.07浙江农业大学动物生理生化专业1991年7月获硕士学位 1991.07-1999.07浙江农业大学饲料科学研究所从事动物营养与饲料科学研究 1992.01-1996.01浙江农业大学讲师 1993.09-1993.10美国堪萨斯州立大学动物营养进修 1996.01-1999.12浙江农业大学(浙江大学)副教授 2000.01-至今浙江大学动物科学学院教授 2001.03-2004.06浙江大学动物营养与饲料科学专业2004年6月获博士学位 2004.12-至今浙江大学动物科学学院教授、博士生导师 2007-2008美国Purdue University的Meat Science and Muscle Biology实验室高访学者 教学与课程 饲料学,本科生精品课程,17120721 高级饲料学,研究生必修课程,172101001 动物营养与饲料科学进展,研究生课程,1713004 动物产品品质形成原理,博士生核心课程,1711026 科研 主要从事动物营养与免疫、动物营养与肉质调控以及生物饲料研发的科研和教学工作。动物营养与免疫方面的研究工作主要包括通过对天然抗菌免疫肽的抗菌活性、安全性、稳定性、免疫功能等进行筛选,并进行分子改良和重组表达,开发新型抗菌免疫制剂,以及通过营养调控手段提高猪内源性抗菌肽表达从而增强仔猪及幼龄动物的免疫力,减少抗生素的使用。动物营养与肉质调控方面的研究工作主要是以中国优良地方猪种和外来瘦肉型猪为动物模型,筛选与猪肌内脂肪沉积及肌纤维发育相关的关键功能基因,研究其对肌内脂肪沉积和肌纤维发育的调控作用及机制,为通过营养手段调控肌内脂肪沉积,改善肉质提供依据。生物饲料研发主要开展高效分泌天然抗菌免疫分子、酶和益生菌的新型发酵菌株研发和生物发酵饲料的研究。 近期主要研究项目 仔猪肠道物理屏障对脂肪酸吸收的影响及抗菌肽调控机制研究(国家基金重点项目) 抗菌肽在仔猪肠道免疫中的作用及其机制研究(国家杰出青年科学基金) 乳源抗菌肽介导仔猪先天和获得性免疫的作用及其分子机制(国家基金面上项目) 乳铁蛋白对仔猪骨髓抗菌肽PR-39基因表达的影响(国家基金面上项目) 基于转录后mRNA甲基化修饰水平上的猪肌内脂肪沉积关键基因筛选及其功能鉴定(转基因生物新品种培育重大专项) 猪肌纤维发育与肌内脂肪沉积关键基因克隆与功能鉴定(转基因生物新品种培育重大专项) 机体碳代谢对脂肪沉积和肉品质形成的调控(973项目课题) 优良地方品种猪、鸡肉质性状相关功能基因的表达与营养调控(973项目课题) 饲料用抗菌肽的分子改良与产品研制(863项目课题) 饲用活性肽和防御肽的研制(“十二五”农村领域国家科技计划课题) 优质安全猪肉生产饲料营养技术研究创新团队(农业部创新团队项目) 国家现代农业产业技术体系(生猪产业)岗位科学家(国家现代农业产业技术体系专项基金) 乳源抗菌肽的研究(全国百篇优秀博士论文基金) 畜禽饲用抗生素、重金属元素添加剂减量使用与替代技术的研究与产业化示范(浙江省重大科技专项) 生猪健康养殖饲料营养关键技术研发及应用(重大横向课题) 研究与成果 授权专利: 汪以真,易宏波.Antimicrobial peptide WY-21 and application thereof;美国专利;US9475843B2,2016.10.25 汪以真,易宏波.抗菌肽WY-21及其应用[Z].2017.浙江大学,专利号201510065017.X; 王凤芹、张煜、席玲玲、汪以真.酵母硒总硒、无机硒、有机硒含量的测定方法[Z].2017.浙江大学,专利号201510126749.5; 汪以真,张煜,石常友,王成,路则庆,王凤芹.一种高效降解豆粕抗原蛋白的芽孢杆菌筛选方法[Z].2017.浙江大学,专利号201610728946.9; 汪以真,石常友,张煜,王成,路则庆,王凤芹。高效降解豆粕抗原蛋白的芽孢杆菌及菌酶混合发酵的方法[Z].2017.浙江大学,专利号201610728880.3; 汪以真,张煜,石常友.高效降解豆粕抗原蛋白的芽孢杆菌及其发酵豆粕的方法[Z].2017.浙江大学,专利号201610728303.4; 汪以真,宋德广,路则庆,王凤芹,程远之,李笑笑.Enterobacter cloacae制备生物纳米硒的方法及应用[Z].2017.浙江大学,专利号201610000452.9; 王凤芹,汪以真,张林.一种单质硒含量的测定方法;[Z].2017.浙江大学,专利号201610953809.5; 王凤芹,汪以真,张林.快速定量检测单质晒的方法及分离收集装置[Z].2017.浙江大学,专利号201510364883.9; 蔡青和,王国水,汪以真,陈远庆,郭宝海,毛勇,毛慧敏,计成.一种降低动物粪便中氮磷排泄量的饲料添加剂;专利号201410064146.2; 汪以真,宗鑫,王腾浩.高产抗菌肽地衣芽孢杆菌及其应用[Z].2016.浙江大学,专利号201410653450.0; 汪以真,王腾浩.一种丁酸梭菌及其应用[Z].2015.浙江大学,专利号201410137978.2; 刘金松,曾新福,杨彩梅,汪以真,冯杰.复合菌剂及所采用的复合微生物的连续发酵法[Z].2015.浙江惠嘉生物科技有限公司,浙江大学,专利号201410662273.2 汪以真,黄明,王友明,路则庆,靳明亮.羧甲基化阴沟肠杆菌多糖及其制备方法和应用[Z].2015.浙江大学,专利号201210522681.9 汪以真,栾超,王腾浩,冯杰,杜华华,王新霞,路则庆,杨彩梅.一种丁酸梭菌分泌的抗菌肽及其制备方法和应用[Z].2015.浙江大学,专利号201410030648.3 汪以真,王腾浩,栾超,冯杰,刘金松,一种地衣芽孢杆菌分泌的抗菌肽及其制备方法和应用[Z].2015.浙江大学,专利号ZL201410021906.1; 李治学,汪以真,韩菲菲,刘丹.微量测定阳离子抗菌肽最小抑菌和最小杀菌浓度的方法[Z].2014.浙江大学,专利号201310065813.4; 王凤芹,杨航仙,汪以真.葡萄糖醛酸缩硫醇-乙酸酯衍生物及其制备方法和应用[Z].2014.浙江大学,专利号201210441022.2; 汪以真,伍婷,袁章琴.猪FLJ小干扰RNA表达载体的构建、鉴定法及用途[Z].2014.浙江大学,专利号201110440124.8; 王新霞,汪以真.大黄鱼脂肪细胞体外培养方法[Z].2013.浙江大学,专利号201110030738.9; 伍婷,汪以真,袁章琴.从动物脂肪组织中提取用于基因芯片杂交总RNA的方法[Z].2012.浙江大学,专利号201010551781.5; 向兰,汪以真,戚建华,黄艳娜.小鼠脂联素基因超表达载体的构建及用途[Z].2012.浙江大学,专利号201110088270.9; 单体中,汪以真,伍婷,郭佳,韩菲菲.猪Sirtl小干扰RNA表达载体的构建方法及用途[Z].浙江大学,2009.专利号200810120732.9; 王新霞,汪以真.防治大黄鱼脂肪肝的饲料添加剂[Z].浙江大学,2009.专利号200910096515.5; 汪以真,胡迎利,赵燕飞,胡晓蕾.一种以白术为主方的动物免疫增强剂[Z].浙江大学,2006.专利号200610049161.5; 汪以真,胡迎利,赵燕飞.以黄芪为主方的动物免疫增强剂[Z].浙江大学,2005.专利号200510050161.2; 汪以真,胡迎利,赵燕飞.一种动物免疫增强剂[Z].浙江大学,2005.专利号200510049847.X; 汪以真,许梓荣,黄海青.含乳铁蛋白全蚕粉的生产方法[Z].浙江大学,2003.专利号03115855.2; 奖励荣誉 2001年高效转化、肉质改良和资源开发型全价饲料的研发及产业化,国家科技进步奖二等奖(第二) 2018年禽抗生素减量和养分减排的新型微生态制剂技术研究与产业化,浙江省科技进步奖一等奖(第一) 2017年畜禽饲用抗生素减量的饲料营养关键技术及应用,中华农业科技奖一等奖(第一) 2013年仔猪抗菌肽高效营养调控技术研究及产业化,教育部科学技术进步奖二等奖(第一) 2015年畜禽抗生素减量和养分减排的饲料营养关键技术研究与产业化,大北农科技成果奖二等奖(第一) 2007年猪抗菌肽及其表达调控研究,浙江省科学技术发明奖二等奖(第一) 1998年新型畜禽营养再分配剂的研制及其产业化技术研究,浙江省科技进步奖二等奖(第一) 2012年氨基酸络合微量元素饲料添加剂制备关键技术、生物学效应及产业化,浙江省科学技术奖二等奖(第三) 2010年国家杰出青年基金获得者 2014年国务院学位委员会第七届学科评议组成员 2009年全国百篇优秀博士论文获得者 2013年国务院特殊津贴专家 2013年国家有突出贡献中青年专家 2013年“百千万”人才工程国家级人选 2018年国家“万人计划”科技创新领军人才 2004年教育部新世纪人才 2010年全国百篇优博题名指导教师 2016年中国畜牧兽医学会动物营养学分会副理事长 2015年全国农业科研杰出人才 2015年农业部创新团队负责人 2016年国家重点领域创新团队(科技部)负责人 2015年第三届全国饲料评审委员会副主任委员 2016年第五届全国饲料工业标准化技术委员会委员 2017年第四届农业专业学位研究生教育指导委员会委员 2001年浙江省突出贡献中青年 2004年浙江省151人才第一层次 2014年浙江省畜牧产业技术创新与推广服务团队专家 学术交流(讲座报告) 2012.09.24抗生素替代物大会(法国)(Alternatives to Antibiotics,Challenges and solutions in animal production) 2014.05.31动物源抗菌肽的研究现状和未来(生物兽药产业发展与抗菌肽科研高峰论坛) 2014.11.17生物饲料研究与安全(第二届生物饲料科技大会) 2015.06.04我国畜牧业面临的挑战与对策(“大宗非粮型饲料资源高效利用战略研究项目”启动会) 2015.08.31新型饲料添加剂的研究进展(第一届北京畜牧兽医工程科技高峰论坛) 2015.09.14生物饲料与食品安全(第三届生物饲料科技大会) 2015.10.17脂肪代谢营养调控与优质猪肉生产(第七届猪营养学术研讨会) 2015.11.18畜禽养殖生产中面临的问题及初步思考(“生物标准化养殖与生产效益持续提升研讨”畜牧兽医学术年会) 2016.09.06生物发酵饲料研究与质量安全评价(第四届生物饲料科技大会) 2017.04.17富硒多糖与生物微量元素的研发(太阳鸟·畜牧产业无抗发展大会) 2017.05.11从动物产品安全与品质谈学科交叉研究(紫荆国际青年科学家论坛) 2017.10.19我国畜牧业发展现状与趋势(农民企业家培训班) 2017.10.28抗生素减量与替代的一些思考(四川省饲料工业协会调研三十周年庆典) 2017.11.19 Animal Health and Ecological Farming(浙江大学农业绿色发展学术论坛) 2017.12.12饲料源头控制与畜禽生态养殖(浙江省畜牧业绿色发展高峰论坛) 2017.11.03浙大动科的挑战和机遇(全国畜牧学科高峰论坛暨动科学院院长(所长)联席会议) 2017.10.21从动物产品安全与品质谈分子营养研究(动物科技学院学科发展前沿暨青年学者论坛) 2018.04.17绿色养殖大趋势下的添加剂创新与选择(太阳鸟·营养与创新大会) 实验室介绍 实验室成员: 实验室教师10人。正高职称4人,副高职称4人,中级职称2人。其中国家杰出青年基金获得者1人,国家百千万人才1人,国家万人计划1人,国家突出贡献中青年专家1人,国家农业产业体系岗位专家1人,国家优秀青年基金获得者1人,教育部“新世纪优秀人才计划”2人,浙江省杰出青年基金获得者2人,浙江省151人才第一层次1人。实验室负责人汪以真教授是国务院学位委员会畜牧学科评议组专家、全国饲料评审委员会副主任委员、中国畜牧兽医学会动物营养学分副理事长、“生物饲料安全与污染防控”国家工程实验室常务副主任、科技部和农业部创新团队负责人,是浙江大学“动物分子营养”海外学术大师工作室(诺奖团队)的负责人。 本团队先后与美国、加拿大等多个国家的高校及科研机构建立了稳定的海外合作交流关系,与2015年诺贝尔化学奖得主Tomas Lindahl教授、芝加哥何川教授以及普渡大学匡世焕教授等合和建立了首批浙江大学“动物分子营养”海外学术大师联合工作室。 研究方向: 营养与免疫——在研究仔猪先天性免疫因子表达和免疫细胞发育的基础上,研究应激对猪先天性免疫功能的影响,探讨营养素缓解应激并增强猪抗细菌感染免疫的分子机制,解析营养-肠道-免疫的互作网络,研发增强猪自身抵抗力和机体健康的新型抗免疫技术及产品。 营养与肉品质——通过研究猪肌肉生长、发育及脂肪沉积等规律,从干细胞、糖脂代谢、表观遗传等角度,深入探讨猪肉品质形成的关键基因调控网络及表观遗传机制,研发靶向调控猪肉品质的饲料营养关键技术及产品。 营养与肠道健康——研究猪小肠隐窝-绒毛轴更新、肠上皮细胞紧密连接和肠道菌群的发育性变化,探讨断奶应激、感染、环境等内外因子引起的肠道菌群紊乱、肠屏障损伤及其重建与修复分子机制,解析参与肠屏障功能修复的关键信号通路及肠道菌群-信号分子-肠黏膜屏障的网络关系,研发肠屏障功能的靶向调节技术及其相关产品。 微量元素营养与代谢——研究无机微量元素的吸收代谢及其过载效应,在此基础上,研发新型有机微量元素,并探究其生物学效应及吸收机制,同时开展饲料原料中微量元素存在形式、束缚因子及生物学利用率,研发提高饲料原料本底微量元素利用效率的生物学技术。 生物发酵饲料——围绕提高糟渣等低值饲料原料和玉米豆粕等常规饲料原料利用率,选育高效降解抗原蛋白、纤维、植酸等抗营养因子的发酵菌株,探索发酵过程饲料养分的变化规律和机制,建立混菌发酵、菌酶协同的规模化发酵饲料生产工艺和饲喂模式,研究发酵饲料对母猪繁殖性能、仔猪生长健康和育肥猪猪肉品质的改善作用和机制。

研究领域

动物营养与免疫 动物营养与肉质调控 生物饲料

近期论文

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发表的SCI论文(2000-2018.5) 在Nature Communications、Biomaterials、Journal of immunology及J.Anim.Sci和J.Dairy.Sci等杂志上发表SCI论文100余篇。 Weiche Wu,Sisi Wang,Qing Liu,Tizhong Shan,Yizhen Wang*.Metformin protects against LPS-induced intestinal barrier dysfunction by activating AMPK pathway.Molecular pharmaceutics.2018,15(8):3272–3284. Xinxia Wang,Baofa Sun,Qin Jiang,Ruifan Wu,Min Cai,Yongxi Yao,Qing Liu,Hailing Shi,Jie Feng&Yizhen Wang*.mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.International Journal of Obesity.2018. Ruifan Wu,Yongxi Yao,Qin Jiang,Min Cai,Qing Liu,Yizhen Wang*,Xinxia Wang*.Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m6A-YTHDF2 dependent manner.International Journal of Obesity.2018,42(7):1378-1388. Cheng Wang,Changyou Shi,Yu Zhang,Deguang Song,Zeqing Lu,Yizhen Wang*.Microbiota in fermented feed and swine gut.Applied Microbiology and Biotechnology.2018,102(7):2941-2948. Weiche Wu,Sisi Wang,Ziye Xu,Xinxia Wang,Jie Feng,Tizhong Shan,Yizhen Wang*.Betaine promotes lipid accumulation in adipogenic-differentiated skeletal muscle cells through ERK/PPARγsignalling pathway.Molecular and Cellular Biochemistry.2018(5):1-13. Wang C,Lin C,Su W,Zhang Y,Wang F,Wang Y,Shi C,Lu Z*.Effects of supplementing sow diets with fermented corn and soybean meal mixed feed during lactation on the performance of sows and progeny.Journal of Animal Science.2018,96(1):206-214. Wu W,Xu Z,Zhang L,Liu J,Feng J,Wang X,Shan T,Wang Y*.Muscle-specific deletion of Prkaa1 enhances skeletal muscle lipid accumulation in mice fed a high-fat diet.Journal of Physiology&Biochemistry.2018,74(2):195-205. Chen S,Lu Z,Wang F,Wang Y*.Cathelicidin-WA polarizes E.coli K88-induced M1 macrophage to M2-like macrophage in RAW264.7 cells.International Immunopharmacology.2018,54:52-59. Caihua Yu,Lingling Xi,Jin Chen,Qin Jiang,Hongbo Yi,Yizhen Wang,Xinxia Wang*.PAM,OLA,and LNA are Differentially Taken Up and Trafficked Via Different Metabolic Pathways in Porcine Adipocytes.Lipids.2017,52(11):929-938 Yuanzhi Cheng,Xiao Xiao,Xiaoxiao Li,Deguang Song,Zeqing Lu,Fengqin Wang,Yizhen Wang*.Characterization,antioxidant property and cytoprotection of exopolysaccharide-capped elemental selenium particles synthesized by Bacillus paralicheniformis SR14.Carbohydrate Polymers.2017,178:18-26. Shi C,Zhang Y,Yin Y,Wang C,Lu Z,Wang F,Feng J,Wang Y*.Amino acid and phosphorus digestibility of fermented corn-soybean meal mixed feed with Bacillus subtilis and Enterococcus faecium fed to pigs.Journal of Animal Science.2017,95(9):3996-4004. Yu Zhang,Changyou Shi,Cheng Wang,Zeqing Lu,Fengqin Wang,Jie Feng&Yizhen Wang*.Effect of soybean meal fermented with Bacillus subtilis BS12 on growth performance and small intestinal immune status of piglets.Food and Agricultural Immunology.2017,(25679):1-14. Changyou Shi,Yu Zhang,Zeqing Lu,Yizhen Wang*.Solid-state fermentation of corn-soybean meal mixed feed with Bacillus subtilis and Enterococcus faecium for degrading antinutritional factors and enhancing nutritional value.Journal of Animal Science&Biotechnology.2017,8(1):50. Deguang Song,Xiaoxiao Li,Yuanzhi Cheng,Xiao Xiao,Zeqing Lu,Yizhen Wang*,Fengqin Wang*.Aerobic biogenesis of selenium nanoparticles by Enterobacter cloacae Z0206 as a consequence of fumarate reductase mediated selenite reduction.Scientific Reports.2017,7:3239-3248. Deguang Song,Yuanzhi Cheng,Xiaoxiao Li,Fengqin Wang,Zeqing Lu,Xiao Xiao,Yizhen Wang*.Biogenic nano-selenium particles effectively attenuate oxidative stress-induced intestinal epithelial barrier injury by activating the Nrf2 antioxidant pathway.ACS applied materials&interfaces.2017,9(17):14724-14740. Deguang Song,Xiaoxiao Li,Yuanzhi Cheng,Guixing Wu,Xiao Xiao,Fengqin Wang,Yizhen Wang*and Zeqing Lu*.Effects of supplementing sow diets with Saccharomyces cerevisiae refermented sorghum dried distiller’s grains with solubles from late gestation to weaning on the performance of sows and progeny.Journal of Animal Science.2017,95:2025-2031. Hongbo Yi,Wangyang Hu,Shan Chen,Zeqing Lu,Yizhen Wang*.Cathelicidin-WA improves intestinal epithelial barrier function and enhances host defense against enterohemorrhagic Escherichia coli O157:H7 infection.Journal of Immunology.2017,198(4):1696-1705. Weiche Wu,Jie Feng,Denghu Jiang,Xihong Zhou,Qin Jiang,Min Cai,Xinxia Wang,Tizhong Shan,Yizhen Wang*.AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine.Scientific Reports.2017,7:41606. Jiaqi Liu,Ziye Xu,Weiche Wu,Yizhen Wang,Tizhong Shan*.Cre Recombinase Strains Used For the Study of Adipose Tissue and Adipocyte Progenitors.Journal of Cellular Physiology.2017,232(10):2698. Xinxia Wang,Yizhen Wang*.From Histones to RNA:Role of Methylation in Signal Proteins Involved in Adipogenesis.Current Protein and Peptide Science.2017,18(6):589-598. Tizhong Shan*,Jiaqi Liu,Weiche Wu,Ziye Xu,Yizhen Wang.Roles of Notch Signaling in Adipocyte Progenitor Cells and Mature Adipocytes.Journal of Cellular Physiology.2016,232(6):1258-1261. Tizhong Shan*,Ziye Xu,Jiaqi Liu,Weiche Wu.Yizhen Wang*.Lkb1 Regulation of Skeletal Muscle Development,Metabolism and Muscle Progenitor Cell Homeostasis.Journal of Cellular Physiology.2017,232(10):2653-2656. Jianzhao Liu,Yuanxiang Zhu,Guan-Zheng Luo,Xinxia Wang,Yanan Yue,Xiaona Wang,Xin Zong,Kai Chen,Hang Yin,Ye Fu,Dali Han,Yizhen Wang*,Dahua Chen&Chuan He.Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.Nature Communications.2016,7:13052. Tizhong Shan*,Ziye Xu,Weiche Wu,Jiaqi Liu,Yizhen Wang.Roles of Notch1 Signaling in Regulating Satellite Cell Fates Choices and Postnatal Skeletal Myogenesis.Journal of Cellular Physiology.2016,232(11):2964-2967. Tizhong Shan,Yan Xiong,Pengpeng Zhang,Zhiguo Li,Qingyang Jiang,Pengpeng Bi,Feng Yue,Gongshe Yang,Yizhen Wang,Xiaoqi Liu&Shihuan Kuang*.Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3.Nature Communications.2016,7:12205. Tizhong Shan*,Pengpeng Zhang,Qinyang Jiang,Yan Xiong,Yizhen Wang,Shihuan Kuang*.Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice.Diabetologia.2016,(9):1-10. Tizhong Shan*,Pengpeng Zhang,Yan Xiong,Yizhen Wang,Shihuan Kuan*.Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts.International Journal of Biochemistry and Cell Biology.2016,76:31-38. Qin Jiang,Haiwen Zhang,Yonggang Xie,Yizhen Wang*.Recombinant expression of porcine lactoferrin peptide LF-6 with intein technology and its immunomodulatory function in ETEC K88-infected mice.International Immunopharmacology.2016,39:181-191. Xiaobin Wang,Qingwu W.Shen*,Jie Wang,Zhiguo Zhang,Fu Feng,Ting Chen,Yanyan Zhang,Huan Wei,Zhongwen Li,Xinxia Wang,Yizhen Wang.KLF7 Regulates Satellite Cell Quiescence in Response to Extracellular Signaling.Stem Cells.2016,34(5):1310-1320. Lu ZQ,Ren Y,Zhou XH,Yu XF,Huang J,Yu DY,Wang XX,Wang YZ*.Maternal dietary linoleic acid supplementation promotes muscle fibre type transformation in suckling piglets.Journal of Animal Physiology and Animal Nutrition.2016,101(6):1130-1136. Ruifan Wu,Denghu Jiang,Yizhen Wang,Xinxia Wang*.N 6-Methyladenosine(m6A)Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification.Molecular Biotechnology.2016,58(7):450-459. Hongbo Yi,Denghu Jiang,Lin Zhang,Haitao Xiong,Feifei Han,YizhenWang*.Developmental expression of STATs,nuclear factor-kappaB and inflammatory genes in the jejunum of piglets during weaning.International Immunopharmacology.2016,36:199-204 Han F,Lu Z,Liu Y,Xia X,Zhang H,Wang X,Wang Y*.Cathelicidin-BF ameliorates lipopolysaccharide-induced intestinal epithelial barrier disruption in rat.Life Sciences.2016,152:199-209. Yi H,Zhang L,Gan Z,Xiong H,Yu C,Du H,Wang Y*.High therapeutic efficacy of Cathelicidin-WA against postweaning diarrhea via inhibiting inflammation and enhancing epithelial barrier in the intestine.Scientific Reports.2016,6:25679. Xiong H,Guo B,Gan Z,Song D,Lu Z,Yi H,Wu Y,Wang Y*,Du H*.Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition.Scientific Reports.2016,6:27070. Zong X,Hu W,Song D,Li Z,Du H,Lu Z,Wang Y*.Porcine lactoferrin-derived peptide LFP-20 protects intestinal barrier by maintaining tight junction complex and modulating inflammatory response.Biochemical Pharmacology.2016,104:74-82. Zhou X,Chen J,Chen J,Wu W,Wang X,Wang Y*.The beneficial effects of betaine on dysfunctional adipose tissue and N6-methyladenosine mRNA methylation requires the AMP-activated protein kinaseα1 subunit.Journal of Nutritional Biochemistry.2015,26(12):1678-1684. Zhou X,Chen J,Wu W,Wang X,Wang Y*.Role of adenosine 5'-monophosphate-activated protein kinase inα-linolenic acid-induced intestinal lipid metabolism.British Journal of Nutrition.2015,114(6):866-872. Hongbo Yi,Caihua Yu,Haiwen Zhang,Deguang Song,Denghu Jiang,Huahua Du,Yizhen Wang*.Cathelicidin-BF suppresses intestinal inflammation by inhibiting the nuclear factor-κB signaling pathway and enhancing the phagocytosis of immune cells via STAT-1 in weanling piglets.International Immunopharmacology.2015,28(1):61-69. Chen J,Zhou X,Wu W,Wang X,Wang Y*.FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice.Journal of Physiology&Biochemistry.2015,71(3):405-413. Haiwen Zhang,Xi Xia,Feifei Han,Qin Jiang,Yili Rong,Deguang Song,and Yizhen Wang*.Cathelicidin-BF,a Novel Antimicrobial Peptide from Bungarus fasciatus,Attenuates Disease in a Dextran Sulfate Sodium Model of Colitis.Molecular Pharmaceutics.2015,12(5):1648-1661. Zong X,Song D,Wang T,Xia X,Hu W,Han F,Wang Y*.LFP-20,a porcine lactoferrin peptide,ameliorates LPS-induced inflammation via the MyD88/NF-κB and MyD88/MAPK signaling pathways.Developmental and Comparative Immunology.2015,52(2):123-131. Wang X,Feng J,Yu C,Shen QW,Wang Y*.Alterations in oral[1-(14)C]18:1n-9 distribution in lean wild-type and genetically obese(ob/ob)mice.Plos One.2015,10(3):e0122028. Wang Xinxia,Li Yongjin,Hou Chonglin,Gao Yang,Wang Yizhen*.Physiological and molecular changes in large yellow croaker(Pseudosciaena crocea R.)with high-fat diet-induced fatty liver disease.Aquaculture Research.2015,46(2):272-282. Wang Xinxia,Zhu Linna,Chen Jingqing,Wang Yizhen*.RNA m(6)A methylation downregulates adipogenesis in porcine adipocytes.Biochemical and Biophysical Research Communications.2015,459(2):201-207. Deguang Song,Xin Zong,Haiwen Zhang,Tenghao Wang,Hongbo Yi,Chao Luan,Yizhen Wang*.Antimicrobial peptide Cathelicidin-BF prevents intestinal barrier dysfunction in a mouse model of endotoxemia.International Immunopharmacology.2015,25:141-147. Zhou X,Wu W,Chen J,et al.AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid.Nutrition&Metabolism.2015,12(1):1-8. Xi Xia,Lin Zhang,Yizhen Wang*Zhou X,Wu W,Chen J,et al.AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid[J].Nutrition&Metabolism.2015,12(1):1-8. Xi Xia,Lin Zhang,Yizhen Wang*.The antimicrobial peptide cathelicidin-BF could be a potential therapeutic for Salmonella Typhimurium infection.Microbiological Research.2015,171:45-51. Feifei Han,Haiwen Zhang,Xi Xia,Haitao Xiong,Deguang Son,Xin Zong,Yizhen Wang*.Porcineβ-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitisIssue.Journal of Immunology.2015,194:1882-1893. Ming Huang,Fengqin Wang,Xihong Zhou,Hangxian Yang,Yizhen Wang*.Hypoglycemic and hypolipidemic properties of polysaccharides fromEnterobacter cloacae Z0206 in KKAy mice.Carbohydrate Polymers.2015,117:91-98. Chao Luan,Yong Gang Xie,Yu Tian Pu,Hai Wen Zhang,Fei Fei Han,Jie Feng,Yi Zhen Wang*.Recombinant expression of antimicrobial peptides using a novel self-cleaving aggregation tag in Escherichia coli.Canadian Journal of Microbiology.2014,60:113–120. Xihong Zhou,Jingqing Chen,Fengqin Wang,Hangxian Yang,Ren Yang,Xinxia Wang and Yizhen Wang*.Selenium-enriched exopolysaccharides improve skeletal muscle glucose uptake of diabetic KKAy mice via AMPK pathway.Journal of Physiology&Biochemistry.2014,70(2):547-554. Zhou Xihong,Wang Fengqin,Yang Hangxian,Chen Jingqing,Ren Yang,Yuan Zhangqin,Wang Xinxia,Wang Yizhen*.Selenium-enriched exopolysaccharides produced by enterobacter cloacae z0206 alleviate adipose infammation in diabetic kkay mice through the ampk/sirt1 pathway.Molecular medicine reports.2014,2(9):683-688. Jin Mingliang,Wang Youming,Huang Ming,Lu Zeqing,Wang Yizhen*.Sulphation can enhance the antioxidant activity of polysaccharides produced by Enterobacter cloacae Z0206.Carbohydrate polymers.2014.2(99):624-629. ZhangQin Yuan,DeGuang Song,YiZhen Wang*.The novel gene pFAM134B positively regulates fat deposition in the subcutaneous fat of Sus scrofa.Biochemical and Biophysical Research Communications.2014,454(4):554-559. Yanhua Gao,Yili Rong,Youming Wang,Haitao Xiong,Xia Huang,Feifei Han,Jie Feng,Yizhen Wang*.Expression pattern of porcine antimicrobial peptide PR-39 and its induction by enterotoxigenic Escherichia coli(ETEC)F4ac.Veterinary Immunology and Immunopathology.2014,160:260-265. Tizhong Shan,Yang Ren,Yizhen Wang*.Sirtuin1 affects the transcriptional expression of adipose triglyceride lipase in porcine adipocytes.Journal of Animal Science.2013,91(3):1247-1254. Y.‐F.Zhang,Z.‐Q.Yuan,D.‐G.Song,X.‐H.Zhou,Y.‐_x001a_.Wang*.Effects of cannabinoid receptor 1(brain)on lipid accumulation by transcriptional control of CPT1A and CPT1B.Animal Genetics.2013,45:38-47. Yonggang Xie,Yifan Liu,Chao Luan,Feifei Han,Ren Lai,Groleau Denis,Jie Feng,Yizhen Wang*.Effects of amino acid deletion and substitution on the chemical properties,biological activities of the frog peptide Palustrin-OG1.Protein and Peptide Letters.2013,20(7):813-819. Yonggang Xie,Chao Luan,Haiwen Zhang,Feifei Han,Jie Feng,Young-Jun Choi,Denis Groleau,Yizhen Wang*.Effects of Thioredoxin:SUMO and intein on soluble fusion expression of an antimicrobial peptide OG2 in Escherichia coli.Protein and Peptide Letters.2013,20(1):54-60. Yong-Gang Xie,Fei-Fei Han,Chao Luan,Hai-Wen Zhang,Jie Feng,Young-Jun Choi,Denis Groleau,and Yi-Zhen Wang*.High-Yield Soluble Expression and Simple Purification of the Antimicrobial Peptide OG2 Using the Intein System in Escherichia coli.BioMed research international.2013,2013(7):754319. Zhuo Zhao,Fang Shenglin,Yue Min,Wang Yizhen,Feng Jie*.Iron Glycine Chelate on Meat Color,Iron Status and Myoglobin Gene Regulation of M.longissimus dorsi in Weaning Pigs.International Journal of Agriculture and Biology.2013,15(5):983-987. Gao Yanhua,Han Feifei,Huang Xia,Rong Yili,Yi Hongbo,Wang Yizhen*.Changes in gut microbial populations,intestinal morphology,expression of tight junction proteins and cytokine production between two pig breeds after challenge with Escherichia coli K88:a comparative study.Journal of Animal Science.2013,91:5614-5625. YongFei Ying,YinLiang Wu,Yi Wen,Ting Yang,XiuQin Xu,YiZhen Wang*.Simultaneous determination of six resorcylic acid lactones in feed using liquid chromatography–tandem mass spectrometry and multi-walled carbon nanotubes as a dispersive solid phase extraction sorbent.Journal of Chromatography A.2013,1307:41-48. LinNa Zhu,Yang Ren,JingQing Chen,YiZhen Wang*.Effects of myogenin on muscle fiber types and key metabolic enzymes in gene transfer mice and C2C12 myoblasts.Gene.2013,532:246-252. Yang Ren,Jing Huang,Xiufeng Yu,Tizhong Shan1,Xihong Zhou,Xinxia Wang,Yizhen Wang*.Breed difference of porcine Sirtuin 1,adipose triglyceride lipase(ATGL)and hormone sensitive lipase(HSL).Livestock science.2013,158:199-205. Ren Yang,Shan Tizhong,Zhu Linna,Wu Ting,Guo Jia,Wang Yizhen*.Effect of breed on the expression of Sirtuins(Sirt1-7)and antioxidant capacity in porcine brain.Animal.2013,7(12):1994-1998. Luan Chao,Zhang Haiwen,Song Deguang,Xie Yonggang,Feng Jie,Wang Yizhen*.Expressing antimicrobial peptide cathelicidin-BF in Bacillus subtilis using SUMO technology.Applied Microbiology and Biotechnology.2013,98(8):3651-3658. Du Huahua,Hou CL,Wu XG,Xie RH,Wang Yizhen*.Antigenic and immunogenic properties of truncated VP28 protein of white spot syndrome virus in Procambarus clarkia.Fish&Shellfish Immunology.2013,34(1):332-338. Han Feifei,Gao Yanhua,Luan Chao,Xie Yonggang,Liu Yifan,Wang Yizhen*.Comparing bacterial membrane interactions and antimicrobial activity of porcine lactoferricin-derived peptides.Journal of Dairy Science.2013,96(6):3471-3487. Lu Zeqing,Jing Mingliang,Huang Ming,Wang Youming,Wang Yizhen*.Bioactivity of selenium-enriched exopolysaccharides produced by Enterobacter cloacae Z0206 in broilers.Carbohydrate Polymers.2013,96:131-136. Ting Wu,Zhenhai Zhang,Zhangqin Yuan,Li Jan Lo,Jun Chen,Yizhen Wang*,Jinrong Peng*.Distinctive genes determine different intramuscular fat and muscle fiber ratios of the longissimus dorsi muscles in Jinhua and Landrace pigs.Plos One.2013,8(1):e53181. Yifan Liu,Xi Xia,Liang Xu,Yizhen Wang*.Design of hybrid b-hairpin peptides with enhanced cell specificity and potent anti-inflammatory activity.Biomaterials.2013,34(1):237-250. Fengqin Wang,Hangxian Yang,Yizhen Wang*.Structure characterization of a fucose-containing exopolysaccharide produced by Enterobacter cloacae Z0206.Carbohydrate Polymers.2013,92(1):503-509. Xinxia Wang,Yizhen Wang,Yongjin Li.Adipose Triglyceride Lipase(ATGL)clone,expression pattern,and regulation by different lipid sources and lipid levels in large yellow croaker(Pseudosciaena crocea R.).Marine Biotechnology.2013,15(2):197-205. Shan T,Ren Y,Wang Y*.Sirtuin 1 affects the transcriptional expression of adipose triglyceride lipase in porcine adipocytes.Journal of Animal Science.2013,91(3):1247-1254. Ting Wu,Xiufeng Yu,Linna Zhu,Yizhen Wang*.Cannabinoid receptor type 1(CB1)antagonist,SR141716 suppresses hepatic CPT1 gene expression in rat.Journal of Animal and Veterinary Advances.2012,11(16):2969-2975. Wu,Xiao-Guo,Xiong,Hai-Tao,Wang,Yi-Zhen*,Du,Hua-Hua*.Evidence for cell apoptosis suppressing white spot syndrome virus replication in Procambarus clarkii at high temperature.Diseases of Aquatic Organisms.2012,102(1):13-21. Xinxia Wang,Ming Huang,Yizhen Wang*.The effect of Insulin,TNFαand DHA on the proliferation,differentiation and lipolysis of preadipocytes isolated from large yellow croaker(Pseudosciaena Crocea R.).Plos One.2012,7(10):1-17. Xinxia Wang,Yongjin Li,Chonglin Hou,Yang Gao,Yizhen Wang*.Influence of different dietary lipid sources on growth,tissue fatty acid composition,histological changes and PPARγgene expression in large yellow croaker(Pseudosciaena crocea R.).Aquaculture Research.2012,43(2):281-291. Mingliang Jin,Zeqing Lu,Ming Huang,Youming Wang,Yizhen Wang*.Effects of Se-enriched polysaccharides produced by Enterobacter cloacae Z0206 on alloxan-induced diabetic mice.International Journal of Biological Macromolecules.2012,50(2):348-352. E.Xu,Linna Zhu,Ren Lai,Jia Guo,Yanna Huang,Ting Wu,Yizhen Wang*.Expression patterns of the cannabinoid receptor 1 gene in pig skeletal muscle and skeletal satellite muscle cells.Journal of Animal and Veterinary Advances.2012,11(23):4297-4303. Yanna Huang,Jianhua Qi,Lan Xiang,Yizhen Wang*.Construction of adiponectin-encoding plasmid DNA and overexpression in mice in vivo.Gene.2012,502(2):87-93. Han,Xin-Yan*,Du,Wen-Li,Huang,Qi-Chun,Xu,Zi-Rong,Wang,Yi-Zheng*.Changes in Small Intestinal Morphology and Digestive Enzyme Activity with Oral Administration of Copper-Loaded Chitosan Nanoparticles in Rats.Biological Trace Element Research.2012,145(3):355-360. Yifan Liu,Feifei Han,Yonggang Xie,Yizhen Wang*.Comparative antimicrobial activity and mechanism of action of bovine lactoferricin-derived synthetic peptides.BioMetals.2011,24(6):1069-1078. Feifei Han,Yifan Liu,Yonggang Xie,Yanhua Gao,Chao Luan,Yizhen Wang*.Antimicrobial peptides derived from different animals:comparative studies of antimicrobial properties,cytotoxicity and mechanism of action.World Journal of Microbiology&Biotechnology.2011,27(8):1847-1857. Yifan Liu,Chao Luan,Xi Xia,Sha An,Yizhen Wang*.Antibacterial activity,cytotoxicity and mechanisms of action of cathelicidin peptides against enteric pathogens in weaning piglets.International Journal of Peptide Research and Therapeutics.2011,17(3):175-184. Mingliang Jin,Youming Wang,Ming Huang,Zeqing Lu,Yizhen Wang*.Optimization of culture medium for exopolysaccharide production by enterobacter cloacae Z0206 using response surface methodology.Asian Journal of Chemistry.2011,23(9):3799-3802. GuoJia Yao,YouMing Wang,YanFang Zhang,Ting Wu,JianXin Liu,Yizhen Wang*.Postnatal Growth Changes of Myoglobin and its Gene Expression Level in M.longissimus Dorsi Muscle of Jinhua and Landrace Barrows.Journal of Animal and Veterinary Advances.2011,10(19):2493-2498. Youming Wang,Ming Huang,Qingping Meng,Yizhen Wang*.Effects of atmospheric hydrogen sulfide concentration on growth and meat quality in broiler chickens.Poultry Science.2011,90(11):2409-2414. Mingliang Jin,Zeqing Lu,Ming Huang,Youming Wang and Yizhen Wang*.Sulfated modification and antioxidant activity of exopolysaccahrides produced by Enterobacter cloacae Z0206.International Journal of Biological Macromolecules.2011,48:607-612. Yizhen Wang,Yanna Huang,Kaiyue Sun,Jianhua Qi,Lan Xiang*.Leptin gene transfer regulates fibromuscular development and lipid deposition in muscles via SIRT1,FOXO3a and PGC-1αin mice in vivo.International Journal of Molecular Medicine.2011,28:617-623. J.Guo,T.Shan,T.Wu,L.N.Zhu,Y.Ren,S.An,Y.Wang*.Comparisons of different muscle metabolic enzymes and muscle fiber types in Jinhua and Landrace pigs.Journal of Animal Science.2011,89(1):185-191. M.L.Jin,Y.M.Wang,C.L.Xu,Z.Q.Lu,M.Huang and Y.Z.Wang*,Preparation and biological activities of an exopolysaccharide produced by Enterobacter cloacae Z0206.Carbohydrate Polymers.2010,81(3):607-611. T.Shan,Y.Ren,Y.Liu,L.Zhu and Y.Wang*,Breed difference and regulation of the porcine Sirtuin 1 by insulin.Journal of Animal Science.2010,88(12):3909-3917. X.X.Wang,Z.Q.Lu,L.N.Zhu,Y.F.Zhang,Y.Ren and Y.Z.Wang*.Innate immune response and related gene expression in red swamp crayfish[Procambarus clarkii(Girard)],induced by selenium-enriched exopolysaccharide produced by bacterium Enterobacter cloacae Z0206.Aquaculture Research.2010,41(11):819-827. Y.M.Wang,Q.P.Meng,Y.M.Guo,Y.Z.Wang,Z.Wang,Z.L.Yao and T.Z.Shan,Effect of Atmospheric Ammonia on Growth Performance and Immunological Response of Broiler Chickens.Journal of Animal and Veterinary Advances.2010,9(22):2802-2806. T.Shan,T.Wu,Y.Reng and Y.Wang*.Breed difference and regulation of the porcine adipose triglyceride lipase and hormone sensitive lipase by TNF alpha.Animal Genetics.2009,40(6):863-870. T.Shan,Y.Wang*,T.Wu,C.Liu,J.Guo,Y.Zhang,J.Liu and Z.Xu.Porcine sirtuin 1 gene clone,expression pattern,and regulation by resveratrol.Journal of Animal Science.2009,87(3):895-904. T.Z.Shan,Y.Ren,T.Wu,C.X.Liu and Y.Z.Wang*.Regulatory Role of Sirt1 on the Gene Expression of Fatty Acid-Binding Protein 3 in Cultured Porcine Adipocytes.Journal of Cellular Biochemistry.2009,107(5):984-991. C.L.Xu,Y.Z.Wang*,M.L.Jin and X.Q.Yang.Preparation,characterization and immunomodulatory activity of selenium-enriched exopolysaccharide produced by bacterium Enterobacter cloacae Z0206.Bioresource Technology.2009,100(6):2095-2097. Yang Hailong,Wang Xu,Liu Xiuhong,Wu Jing,Liu Cunbao,Gong Weiming,Zhao Zhiqiang,Hong Jing,Lin Donghai,Wang Yizheng*,Lai Ren.Antioxidant Peptidomics Reveals Novel Skin Antioxidant System.Molecular and Cellular Proteomics Mcp.2009,8(3):571-583.

学术兼职

国务院学位委员会第七届学科评议组成员 全国农业专业学位研究生教育指导委员会 中国畜牧兽医学会动物营养学分会副理事长 第三届全国饲料评审委员会副主任委员 第五届全国饲料工业标准化技术委员会委员 生物饲料安全与污染防控国家工程实验室常务副主任 教育部“动物分子营养学”重点实验室主任 农业部“动物营养与饲料科学”重点实验室主任 浙江省“饲料与动物营养”重点实验室主任 浙江省饲料产业科技创新服务平台常务副主任 浙江省饲料和饲料添加剂生产许可专家审核委员会副主任委员 浙江省动物营养与动物保健品分会理事长 浙江省饲料与动物保健品协会副会长

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