Brady, Hugh JM - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

个人简介

My research group studies the molecular basis of immune cell development and function. We are particularly interested in the role of the E4bp4/Nfil3 gene in NK cell development and both the function and role of the Mll gene in haematopoietic stem cell self-renewal and immune cell development.

研究领域

My research group studies the molecular basis of immune cell development and function. We are particularly interested in the role of the E4bp4/Nfil3 gene in NK cell development and both the function and role of the Mll gene in haematopoietic stem cell self-renewal and immune cell development.

近期论文

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Boulenouar S, Doisne J-M, Sferruzzi-Perri A, Gaynor LM, Kieckbusch J, Balmas E, Yung HW, Javadzadeh S, Volmer L, Hawkes DA, Phillips K, Brady HJM, Fowden AL, Burton GJ, Moffett A, Colucci Fet al., 2016, The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy, FRONTIERS IN IMMUNOLOGY, Vol: 7, ISSN: 1664-3224 Lee B-C, Kim M-S, Pae M, Yamamoto Y, Eberle D, Shimada T, Kamei N, Park H-S, Sasorith S, Woo JR, You J, Mosher W, Brady HJM, Shoelson SE, Lee Jet al., 2016, Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity, CELL METABOLISM, Vol: 23, Pages: 685-698, ISSN: 1550-4131 Doisne J-M, Balmas E, Boulenouar S, Gaynor LM, Kieckbusch J, Gardner L, Hawkes DA, Barbara CF, Sharkey AM, Brady HJM, Brosens JJ, Moffett A, Colucci Fet al., 2015, Composition, Development, and Function of Uterine Innate Lymphoid Cells, JOURNAL OF IMMUNOLOGY, Vol: 195, Pages: 3937-3945, ISSN: 0022-1767 Kostrzewski T, Brady HJM, 2015, ILC Lineage Specification: To Be or Not 11b, That Is the Question, IMMUNITY, Vol: 43, Pages: 220-222, ISSN: 1074-7613 Xu W, Domingues RG, Fonseca-Pereira D, Ferreira M, Ribeiro H, Lopez-Lastra S, Motomura Y, Moreira-Santos L, Bihl F, Braud V, Kee B, Brady H, Coles MC, Vosshenrich C, Kubo M, Di Santo JP, Veiga-Fernandes Het al., 2015, NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors, CELL REPORTS, Vol: 10, Pages: 2043-2054, ISSN: 2211-1247 Crotta S, Gkioka A, Male V, Duarte JH, Davidson S, Nisoli I, Brady HJM, Wack Aet al., 2014, The Transcription Factor E4BP4 Is Not Required for Extramedullary Pathways of NK Cell Development, JOURNAL OF IMMUNOLOGY, Vol: 192, Pages: 2677-2688, ISSN: 0022-1767 Male V, Brady HJM, 2014, Transcriptional Control of NK Cell Differentiation and Function, TRANSCRIPTIONAL CONTROL OF LINEAGE DIFFERENTIATION IN IMMUNE CELLS, Vol: 381, Pages: 173-187, ISSN: 0070-217X Male V, Nisoli I, Kostrzewski T, Allan DSJ, Carlyle JR, Lord GM, Wack A, Brady HJMet al., 2014, The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 211, Pages: 635-642, ISSN: 0022-1007 Seillet C, Huntington ND, Gangatirkar P, Axelsson E, Minnich M, Brady HJM, Busslinger M, Smyth MJ, Belz GT, Carotta Set al., 2014, Differential Requirement for Nfil3 during NK Cell Development, JOURNAL OF IMMUNOLOGY, Vol: 192, Pages: 2667-2676, ISSN: 0022-1767 Seillet C, Jackson JT, Markey KA, Brady HJM, Hill GR, MacDonald KPA, Nutt SL, Belz GTet al., 2013, CD8 alpha(+) DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3, BLOOD, Vol: 121, Pages: 1574-1583, ISSN: 0006-4971 Tong X, Zhang D, Buelow K, Guha A, Arthurs B, Brady HJM, Yin Let al., 2013, Recruitment of Histone Methyltransferase G9a Mediates Transcriptional Repression of Fgf21 Gene by E4BP4 Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 5417-5425, ISSN: 0021-9258 Lee W-H, Salek-Ardakani S, Pandolfi PP, Brady HJM, de Boer J, Williams Oet al., 2012, NPM-MLF1 synergizes with Npm haploinsufficiency to enhance myeloid progenitor activity, LEUKEMIA, Vol: 26, Pages: 1110-1112, ISSN: 0887-6924 Male V, Nisoli I, Gascoyne DM, Brady HJMet al., 2012, E4BP4: an unexpected player in the immune response, TRENDS IN IMMUNOLOGY, Vol: 33, Pages: 98-102, ISSN: 1471-4906 Martin-Fontecha A, Lord GM, Brady HJM, 2011, Transcriptional control of natural killer cell differentiation and function, CELLULAR AND MOLECULAR LIFE SCIENCES, Vol: 68, Pages: 3495-3503, ISSN: 1420-682X de Boer J, Yeung J, Ellu J, Ramanujachar R, Bornhauser B, Solarska O, Hubank M, Williams O, Brady HJMet al., 2011, The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors, LEUKEMIA, Vol: 25, Pages: 321-330, ISSN: 0887-6924 Dunne J, Gascoyne DM, Lister TA, Brady HJM, Heidenreich O, Young BDet al., 2010, AML1/ETO Proteins Control POU4F1/BRN3A Expression and Function in t(8;21) Acute Myeloid Leukemia, CANCER RESEARCH, Vol: 70, Pages: 3985-3995, ISSN: 0008-5472 Stam RW, Den Boer ML, Schneider P, de Boer J, Hagelstein J, Valsecchi MG, de Lorenzo P, Sallan SE, Brady HJM, Armstrong SA, Pieters Ret al., 2010, Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia, BLOOD, Vol: 115, Pages: 1018-1025, ISSN: 0006-4971 Woodward MJ, de Boer J, Heidorn S, Hubank M, Kioussis D, Williams O, Brady HJMet al., 2010, Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes, CELL DEATH AND DIFFERENTIATION, Vol: 17, Pages: 316-323, ISSN: 1350-9047 Cao F, Li X, Hiew S, Brady H, Liu Y, Dou Yet al., 2009, Dicer independent small RNAs associate with telomeric heterochromatin., RNA, Vol: 15, Pages: 1274-1281 Duffin R, Leitch AE, Sheldrake TA, Hallett JM, Meyer C, Fox S, Alessandri AL, Martin MC, Brady HJ, Teixeira MM, Dransfield I, Haslett C, Rossi AGet al., 2009, The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1, FEBS LETTERS, Vol: 583, Pages: 2540-2546, ISSN: 0014-5793