个人简介
教育经历：
2009-2010 美国系统生物学研究所，西雅图，美国，研究员
2006-2009 美国系统生物学研究所，西雅图，美国，博士后
2005-2005 美国德克萨斯大学奥斯丁分校，奥斯丁，美国，博士后
2001-2004 中国科学院植物研究所，理学博士
1998-2001 西北农林科技大学&第四军医大学，理学硕士
1994---1998 石河子大学，植物学学士
工作经历：
2015-至今 江苏省纳米抗体工程技术研发中心，主任
2015-至今 中国科学院上海药物研究所，课题组长，博士后导师
2010-2015 东南大学生命科学研究院担任教授，纳米抗体生物工程课题组长
近期论文
查看导师最新文章
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1.Van de Vosse DW*, Wan Yakun*, Lapetina DL, Chen WM, Chiang JH, Aitchison JD, Wozniak RW. 2013, A role for the nucleoporin Nup170p in chromatin structure and gene silencing. Cell, 152(5):969-983.（*Co-first author）
2.Wan Yakun, Chan-Hsien Lin, Nina E. Arens, Jennifer Smith, Ramsey A. Saleem, Jung-Hsien Chiang, John D. Aitchison. 2010, Histone chaperone Chz1p regulates telomeric anti-silencing by modulating H2B ubiquitination at telomeric chromatin. Nucleic Acids Research, 38(5):1431-1440
3.Li H, Yan J, Ou W, Liu H, Liu S, Wan Yakun*. 2015. Construction of a biotinylated cameloid-like antibody for lable-free detection of apolipoprotein B-100. Biosensors & bioelectronics, 64:111-118
4.Ma L, Sun Y, Kang X, Wan Yakun*. 2014. Development of nanobody-based flow injection chemiluminescence immunoassay for sensitive detection of human prealbumin. Biosensors & bioelectronics, 61:165-71
5.Wang H, Li G, Zhang Y, Zhu M, Ma H, Du B, Wei Q, Wan Yakun*. 2015, Nanobody-Based Electrochemical Immunoassay for Ultrasensitive Determination of Apolipoprotein-A1 Using Silver Nanoparticles Loaded Nanohydroxyapatite as Label. Analytical chemistry, 7(22):11209-14.
6.Liu H, Wang P, Liu L, Min Z, Luo K, Wan Yakun*.2015, Nucleosome alterations caused by mutations at modifiable histone residues in Saccharomyces cerevisiae. Scientific Reports, 5:15583.
7.Henan Li, Yawen Mu, Junrong Yan, Yakun Wan*, Songqin Liu. 2015. Label-free photoelectrochemical immunosensor for neutrophil gelatinase-associated lipocalin based on the use of nanobodies. Analytical Chemistry, 87(3):2007-15.
8.Wan Yakun, Saleem RA, Ratushny AV, Roda O, Smith JJ, Lin CH, Chiang JH, Aitchison JD. 2009, Role of the histone variant H2A.Z/Htz1p in TBP recruitment, chromatin dynamics, and regulated expression of oleate-responsive genes. Molecular and Cellular Biology, 29(9):2346-2358
9.Mi L, Wang P, Yan J, Qian J, Lu J, Yu J, Wang Y, Liu H, Zhu M, Wan Yakun*, Liu S. 2016, A novel photoelectrochemical immunosensor by integration of nanobody and TiO2 nanotubes for sensitive detection of serum cystatin C. Analytica chimica acta, 902:107-14.
10.Yan J, Wang P, Zhu M, Li G, Romao E, Xiong S, Wan Yakun*. 2015, Characterization and applications of Nanobodies against human procalcitonin selected from a novel na?ve Nanobody phage display library. Journal of Nanobiotechnology, 6;13:33.
11.Wan Yakun*, Arens CE, Wang S, Zuo X, Zhuo Y, Xing J, Liu H. 2013, Role of the repressor Oaf3p in the recruitment of transcription factors and chromatin dynamics during the oleate response. Biochemical Journal, 449(2):507-517.
12.Li H, Sun Y, Elseviers J, Muyldermans S, Liu S, Wan Yakun*. 2014. A nanobody-based electrochemiluminescent immunosensor for sensitive detection of human procalcitonin, Analyst, 139(15):3718-21.
13.Liu H, Luo K, Zhou Z, Mu Y, Wan Yakun*. 2014. Histone chaperone Chz1 facilitates the disfavouring property of Spt16 to H2A.Z-containing genes in Saccharomyces cerevisiae. Biochemical Journal, 460(3):387-97 （*通讯作者）
14.Yan J, Li G, Hu Y, Ou W, Wan Yakun*. 2014. Construction of a synthetic phage-displayed Nanobody library with CDR3 regions randomized by trinucleotide cassettes for diagnostic applications. Journal of Translational Medicine, 12(1):343.
15.Min Zhu, Xue Gong, Yonghong Hu, Weijun Ou, Yakun Wan*. 2014. Streptavidin-biotin-based directional double nanobody sandwich ELISA for clinical rapid and sensitive detection of influenza H5N1. Journal of Translational Medicine, 20;12:352.
16.Min Zhu, Yonghong Hu, Guirong Li, Weijun Ou, Panyong Mao, Shaojie Xin, Wan Yakun*. 2014. Combining magnetic nanoparticle with biotinylated nanobodies for rapid and sensitive detection of influenza H3N2. Nanoscale Research Letters, 9(1):528
17.Liu H, Zhu Min, Mu Y, Liu L, Li G, Wan Yakun. 2014. Distinct roles for histone chaperones in the deposition of HTZ1 in chromatin. Bioscience Reports, 34(5):139
18.Wang P, Li G, Yan J, Wan Yakun. 2014. Fabrication of Biotinylated Camel Nanobody Based Immunoassay for Specific and Sensitive Detection of Cry1F Toxin. Toxicon, 92C:186-192
19.Li M, Zhu M, Zhang C, Liu X, Wan Yakun. 2014. Uniform Orientation of Biotinylated Nanobody as an Affinity Binder for Detection of Bacillus thuringiensis (Bt) Cry1Ac Toxin. Toxins (Basel), 6(12):3208-22
20.Gong X, Zhu M, Li G, Lu X, Wan Yakun*.2015, Specific determination of influenza H7N2 virus based on biotinylated single-domain antibody from a phage-displayed library. Analytical biochemistry, S0003-2697(15)00462-5.
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