钟淑子 - 北京师范大学-香港浸会大学

个人简介

钟淑子教授于1987年在美国伊利诺伊大学获得解剖学与细胞生物学博士学位，之后在美国西北大学医学院从事博士后研究，并在美国洛克菲勒大学作为温斯顿基金学者从事了3年研究，后加入香港大学，在港大从事教学研究工作长达28年。钟淑子教授曾任北师港浸大通识教育办公室及理工科技学部教授，现在是澳门科技大学医学院教授，北师港浸大食品科学与工程专业的客座教授，香港大学、韩国国立忠南大学的荣誉教授，中国人民解放军空军军医大学（第4军医大）、上海交通大学的访问教授。钟淑子教授的研究领包括基因工程小鼠构建、干细胞分化、神经科学、糖尿病及其治疗应用等。已承担过包括国家自然科学基金在内的46项研究项目及56项合作项目，在相关领域发表了包括PNAS在内的160余篇期刊文章和240余篇会议文章，是多个国际著名期刊的编辑及多项科研基金的评审专家。在与制药公司合作的横向研究项目中，获得了4项相关专利。目前，她主要致力于研发中草药和干细胞用于再生医学的潜在药物。

研究领域

基因工程小鼠构建、干细胞分化、神经科学、糖尿病及其治疗应用

近期论文

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Zeng Z, Xia L, Fan X, Ostriker AC, Yarovinsky T, Su M, Zhang Y, Peng X, Xie Y, Pi L, Gu X, Chung SK, Martin KA, Liu R, Hwa J, Tang WH. Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair. J Clin Invest. 2019 Mar 1;129(3):1372-1386. doi: 10.1172/JCI124508. Bian G, Yu C, Liu L, Fang C, Chen K, Ren P, Zhang Q, Liu F, Zhang K, Xue Q, Xiang J, Guo H, Song J, Zhao Y, Wu W, Chung SK, Sun R, Ju G, Wang J. Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling. Sci Signal. 2018 Oct 23;11(553). pii: eaat1470. doi: 10.1126/scisignal.aat1470. He J, Xia M, Yeung PKK, Li J, Li Z, Chung KK, Chung SK, Xia J. PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect. Proc Natl Acad Sci U S A. 2018 Jul 24; 115(30):E7193-E7201. doi: 10.1073/pnas.1716506115. Zhang SQ, Yung KK, Chung SK, Chung SS. Aldo-keto reductases-mediated cytotoxicity of 2- deoxyglucose: A novel anticancer mechanism. Cancer Sci. 2018 Jun; 109(6):1970-1980. doi: 10.1111/cas.13604. Liu XB, Lo CM, Cheng Q, Ng KT, Shao Y, Li CX, Chung SK, Ng IOL, Yu J, Man K. Oval Cells Contribute to Fibrogenesis of Marginal Liver Grafts under Stepwise Regulation of Aldose Reductase and Notch Signaling. Theranostics. 2017 Oct 24; 7(19):4879-4893. doi: 10.7150/thno.20085. eCollection 2017. Xu WW, Li B, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Lee NP, Chan KW, Xu LY, Li EM, Tsao SW, He QY, Cheung AL. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun. 2017 Feb 10;8:14399. doi: 10.1038/ncomms14399. Patrick K.K.Yeung, Angela K.W.Lai, Hyo JinSon, XuZhang,, Stephen S.M.Chung & S K Chung, Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease., Neurobiol Aging. 2017 Feb;50:119-133. https://doi.org/10.1016/j.neurobiolaging.2016.11.008 L Zhou, S L Ma, P K K Yeung, Y H Wong, K W K Tsim, K F So, L C W Lam, & S K Chung, Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac., Translational Psychiatry (2016) 6, doi:10.1038/tp.2016.129, https://www.nature.com/articles/tp2016129.pdf