刘三宏 - 上海中医药大学 - 交叉科学研究院

个人简介

刘三宏，研究员、博士生导师、珍宝岛讲座教授个人简介主要从事中药抗肿瘤药理及肿瘤发病分子机制研究。发现在结直肠癌发生和发展过程中起到重要作用的NFκB、STAT3和Wnt信号通路组成性激活的新机制（Cell Death and Disease，2023；STTT，2020；JMCB，2018；Gastroenterology，2014），发现转录后调控蛋白PUMILIO为结直肠癌治疗干预的新靶标（Nature Communications，2022），发现一批在肿瘤治疗中极具应用潜力的小分子化合物（Cell Chemical Biology，2023；Journal of Medicinal Chemistry，2023; Molecular Therapy-Oncolytics，2022；Theranostics，2021）。目前研究工作主要从免疫杀伤、铁死亡和铜死亡等方面寻找抗肿瘤中药小分子化合物，并阐释其抗肿瘤的分子机制。在Gastroenterology、Nature Communications、PNAS、Intensive Care Medicine、STTT、Cell Chemical Biology、Cell Death and Disease、Journal of Medicinal Chemistry等期刊上发表SCI研究论文50余篇（总IF>500，平均IF>10）。先后主持国家自然科学基金等课题和人才项目10余项，申请国内外专利10项。招生专业院系名称专业大类一级学科专业代码/专业名称学位类型招生类型交叉科学研究院医学中药学 100800/中药学学术学位博士/硕士交叉科学研究院医学中药学 105600/中药学专业学位硕士教育及任职经历 1997.09-2001.07　河南农业大学学士 2001.09-2004.06　中国农业科学院硕士 2004.09-2008.01　中国农业科学院博士 2008.02-2015.02　中国科学院上海生命科学研究院　　助理研究员、博士后、副研究员 2015.03-2020.06　上海科技大学免疫化学研究所　　　副研究员 2020.07-至今　　上海中医药大学交叉科学研究院　　研究员、博士生导师近五年以第一负责人承担的科研课题与经费序号课题类型项目时间项目经费（万元）备注 1 上海市地方高水平大学建设引进人才科研经费2020.07-2023.07 150 主持 2 国家自然科学基金面上项目 2018.01-2021.12 60 主持

研究领域

中药抗肿瘤药理与肿瘤发病机制

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Chao Lv#, Yun Huang#, Qun Wang#, Chengji Wang#, Hongmei Hu, Hongwei Zhang, Dong Lu, Honghong Jiang, Ruling Shen, Weidong Zhang*, Sanhong Liu*. Ainsliadimer A induces ROS-mediated apoptosis in colorectal cancer cells via directly targeting peroxiredoxin 1 and 2. Cell Chemical Biology, 2023. 30: 295-307. 封面文章，IF=9.039 2. Panpan Fu#, Qun Wang#, Qing Zhang#, Yang Jin, Jin Liu, Kaixian Chen, Yuewei Guo*, Sanhong Liu*, Xuwen Li*. Bioactivity-Driven Synthesis of Marine Natural Product Naamidine J and Its Derivatives as Potential Tumor Immunological Agents by Inhibiting PD-L1. Journal of Medicinal Chemistry, 2023. doi: 10.1021/acs.jmedchem.2c01702. IF=8.039 3. Ye D#, Liu H#, Zhao G#, Chen A, Jiang Y, Hu Y, Liu D, Xie N, Liang W, Chen X, Zhang H, Li C, Wang J, Sun D, Chen W, Tan D, Wang Q, Wang H, Yu D, Wu B, Wang M, Cui S*, Liu S*, Zhang X*. LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis. Cell Death and Disease. 2023. 14(2):165. IF=9.685 4. Yuanyuan Gong#, Zukai Liu#, Yihang Yuan#, Zhenzhen Yang#, Jiawei Zhang, Qin Lu, Wei Wang, Chao Fang*, Haifan Lin*, Sanhong Liu*. PUMILIO proteins promote colorectal cancer growth via suppressing p21. Nature Communications. 2022. 13(1):1627. IF=17.694 5. Yun Zhang, Shuaijun Li, Peisheng Jin, Ting Shang, Ruizhu Sun, Laiya Lu, Kaijin Guo, Jiping Liu, Yuanjuan Tong, Junbang Wang, Sanhong Liu, Chen Wang, Yubing Kang, Wenmin Zhu, Qian Wang, Xiaoren Zhang, Feng Yin, Yi Sun*, Lei Cui*. Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis, Nature Communications. 2022. 4;13(1):2447. IF=17.694 6. Zhang H#, Hu Y#, Liu D#, Liu Z, Xie N, Liu S, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Yan X, Liu Y, Chen CD, Huang X, Eugene Chin Y, Shi Y, Wu B, Zhang X*. The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes. Cell Death and Differentiation. 2022. 10.1038/s41418-021-00921-w. IF=12.067 7. Jin J#, Wu Y#, Zhao Z#, Wu Y, Zhou YD, Liu S, Sun Q, Yang G, Lin J, Nagle DG, Qin J, Zhang Z, Chen HZ, Zhang W, Sun S, Luan X*. Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer. JCI Insight. 2022. 7(22):e160606. IF=9.484 8. Chao Lv#, Yun Huang#, Rui Huang, Qun Wang, Hongwei Zhang, Jinmei Jin, Dong Lu, Yudong Zhou, Yunheng Shen, Weidong Zhang*, Xin Luan*, Sanhong Liu*. Narciclasine targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Molecular Therapy-Oncolytics. 2022. 24: 340-354. IF=6.311 9. Huang R#, Zhang LJ#, Jin JM#, Zhou YD, Zhang HW, Lv C, Lu D, Wu Y, Zhang H, Liu SH, Chen HZ, Luan X*, Zhang WD*. Bruceine D inhibits HIF-1a-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction. Acta Pharm Sin B. 2021. 11(11):3481-3492. IF=14.903 10. Hu Y#, Zhang H#, Xie N, Liu D, Jiang Y, Liu Z, Ye D, Liu S, Chen X, Li C, Wang Q, Huang X, Liu Y, Shi Y, Zhang X*. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Cell Death and Differentiation. 2021. 10.1038/s41418-021-00908-7. IF=12.067 11. Jiang Y#, Li F#, Gao B#, Ma M, Chen M, Wu Y, Zhang W, Sun Y*, Liu S*, Shen H*. KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma. Theranostics. 2021. 11: 3868-3881. 封面文章，IF=11.6 12. Chen Y#, Fang Z#, Tang Y#, Jin Y#, Guo C#, Hu L, Xu Y, Ma X, Gao J, Xie M, Zang X, Liu S, Chen H, Thomas RK, Xue X*, Ji H*, Chen L*. Integrative analysis of multi-omics data reveals the heterogeneity and signatures of immune therapy for small cell lung cancer. Clinical and Translational Medicine. 2021. 11(12), e620. IF=11.492 13. Wu Y#, Lu D#, Jiang Y, Jin J, Liu S, Chen L, Zhang H, Zhou Y, Chen H, Nagle DG, Luan X*, Zhang W*. Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma. Journal of Medicinal Chemistry. 2021. 64: 5802-5815. 封面文章，IF=8.039 14. Peng W#, Chang M#, Wu Y#, Zhu W#, Tong L#, Zhang G, Wang Q, Liu J, Zhu X, Cheng T, Li Y, Chen X, Weng D, Liu S, Zhang H, Su Y, Zhou J*, Li H*, Song Y*. Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway. Stem Cell Research & Therapy. 2021. 12: 216. IF=8.079 15. Zhang HW#, Lv C#, Zhang LJ, Guo X, Shen YW, Nagle DG, Zhou YD, Liu SH*, Zhang WD*, Luan X*. Application of omics- and multi-omics-based techniques for natural product target discovery. Biomedicine & Pharmacotherapy. 2021. 141: 111833. IF=7.419 16. Zang X#, Wang Q#, Zhou H#, Liu S*, Xue X*. Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study. Intensive Care Medicine. 2020. 46: 1927-1929. IF=41.787 17. Xue XY#, Liu YX#, Wang C#, Gu XJ#, Xue ZQ, Zang XL, Ma XD, Deng H, Liu R*, Pan L*, Liu SH*. Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma. Signal Transduction and Targeted Therapy. 2020. 5: 77. IF=38.104 18. Chen X#, Wang C#, Jiang Y, Wang Q, Tao Y, Zhang H, Zhao Y, Hu Y, Li C, Ye D, Liu D, Jiang W, Chin EY, Chen S, Liu Y, Wang M, Liu S*, Zhang X*. Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer. Signal Transduction and Targeted Therapy. 2020. 5: 52. 封面文章，IF=38.104 19. Shi S, Yang ZZ, Liu S, Yang F, Lin H*. PIWIL1 promotes gastric cancer via a piRNA-independent mechanism. Proc Natl Acad Sci U S A. 2020. 117: 22390-22401. IF=12.779 20. Wang Q#, Chen X#, Jiang Y#, Liu S, Liu H, Sun X, Zhang H, Liu Z, Tao Y, Li C, Hu Y, Liu D, Ye D, Liu Y, Wang M*, Zhang X*. Elevating H3K27me3 level sensitizes colorectal cancer to oxaliplatin. Journal of Molecular Cell Biology. 2020. 12: 125-137. IF=8.185 21. Jiang Y#, Li C#, Wu Q#, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F*, Zhang X*. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nature Communications. 2019.10: 2935. IF=17.694 22. Tao Y#, Liu Z#, Hou Y, Wang S, Liu S, Jiang Y, Tan D, Ge Q, Li C, Hu Y, Liu Z, Chen X, Wang Q, Wang M*, Zhang X*. Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3. Oncogene. 2018. 37: 5887-5900. IF=8.756 23. Liu S#*, Wang Z#, Liu Z#, Shi S, Zhang Z, Zhang J, Lin H*. miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer. Journal of Molecular Cell Biology. 2018. 10: 302-315. 封面文章，IF=8.185 24. Ge QL#, Liu SH#, Ai ZH, Tao MF, Ma L, Wen SY, Dai M, Liu F, Liu HS, Jiang RZ, Xue ZW, Jiang YH, Sun XH, Hu YM, Zhao YX, Chen X, Tao Y, Zhu XL, Ding WJ, Yang BQ, Liu DD, Zhang XR*, Teng YC*. RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis. Cell Death and Disease. 2016. 7: e2402. IF=9.685 25. Chen X#, Cao X#, Sun X, Lei R, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, Hou Y, Wang M, Siebenlist U, Eugene Chin Y, Wang Y, Cao L, Hu G, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death and Disease. 2016. 7: e2508. IF=9.685 26. Wang Z, Liu N, Shi S, Liu S*, Lin H*. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer. Journal of Biological Chemistry. 2016. 291: 10646-10658. F1000推荐论文，IF=5.486 27. Liu Z#, Cao W#, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen CD*, Shi Y*, Zhang X*. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. Journal of Molecular Cell Biology. 2015. 7: 505-516. IF=8.185 28. Liu S#, Sun X#, Wang M#, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X*. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Gastroenterology. 2014. 147: 847-859.e811. IF=33.883

学术兼职

担任《生命的化学》编委会委员、Cell Reports Medicine、STTT、RNA Biology等国际学术期刊审稿专家。