魏海 - 上海中医药大学 - 交叉科学研究院

个人简介

2006年11月于University of Alberta药学系获得生物药剂博士学位。在加拿大长期从事以美国FDA颁布的生物药剂分类系统（Biopharmaceutics Drug Classification System)框架下的新药研究与开发工作，为美国和加拿大药学会会员。主要研究方向为生物药剂学，系统生物学和新型释药系统，包括固体植入剂的研发、利用Caco-2细胞模型研究药物肠道吸收机制、利用计算机生物模型（In Silico）建立体内外相关性，预测口服药物体内的吸收和代谢过程，应用代谢组学及蛋白组学技术平台研究疲劳及药物抗疲劳机理。已建立完善的生物药剂学实验平台，所在实验室配备ICP-MS、UPLC-MS等多台大型分析仪器。与香港中文大学药剂学院院长左中教授课题组及University of Alberta新药研发与创新中心主任Raimar Löbenberg教授及生化系Richard Fahlman副教授建成稳定的合作平台，完成DMPK、代谢组学及毒性机制研究。已有两名博士分别作为交换生在香港中文大学和University of Alberta完成了访问学习。招生专业院系名称专业大类一级学科专业代码/专业名称学位类型招生类型交叉科学研究院医学中药学 100800/中药学学术学位博士/硕士交叉科学研究院医学中药学 105600/中药学专业学位硕士教育及工作经历 1987/09—1991/07，沈阳药科大学药学系，大学本科/学士。 1991/08-1995/12，上海第四制药厂，工业药剂师。 1996/09—2000/02，加拿大University of Alberta药学系，研究生/硕士，导师Dr. Leonard I. Wiebe。 1996/09-2000/01，加拿大University of Alberta，药学系，助理研究员/助教。 2000/08-2001/03，加拿大Enviro-Test Laboratories，化学分析师。 2001/05—2006/11，加拿大University of Alberta药学系，研究生/博士，导师Dr. Raimar Löbenberg。 2001/05-2006/11，加拿大University of Alberta，药学系，助理研究员/助教。 2005/07-2005/10，加拿大Merck Frosst Canada & Co.，实习研究员。 2007/09-至今，上海中医药大学，交叉科学研究院，研究员。近五年以第一负责人承担的科研课题与经费序号课题名称项目时间项目经费（万元）备注 1 威灵仙提取物镇痛创新药物开发 2021.09-2025.09 40 主持 2 改善扶正化瘀片崩解时间及制剂研究 2019.12-2020.07 8 主持 3 应用ICPMS测定生物样品中铁元素的含量 2018.12-2019.12 28 主持 4 芪灵蟾片临床前质量标准、初步稳定性研究 2018.11-2019.12 11 主持 5 蝉花生产菌株传代过程中代谢产物谱分析 2019.05-2019.09 10 主持

研究领域

生物药剂学，系统生物学和新型释药系统，包括固体植入剂的研发、利用Caco-2细胞模型研究药物肠道吸收机制、利用计算机生物模型（In Silico）建立体内外相关性，预测口服药物体内的吸收和代谢过程。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Ze Yu# , Xuan Ye, Hongyue Liu, Huan Li , Xin Hao , Jinyuan Zhang , Fang Kou , Zeyuan Wang, Hai Wei*, Fei Gao* and Qing Zhai*. Predicting Lapatinib Dose Regimen Using Machine Learning and Deep Learning Techniques Based on a Real-World Study. Frontier in Oncology, 2022, 12, 893966. 2. Yuyan Wang#, Wenbin Zhou#, Chunming Lyu, Qiang Li, Fang Kou, Min Jiang*, Hai Wei*. Metabolomics study on the intervention effect of Radix Salviae Miltiorrhizae extract in exercise-induced exhaustion rat using gas chromatography coupled to mass spectrometry[J]. Journal of Chromatography B, 2021, 1178: 122805. 3. Wenbin Zhou#, Bangjie Zhu#, Fang Kou1, Shenglan Qi, Chunming Lv, Yu Cheng*, Hai Wei*. Targeted metabolic profiling and PRM analysis of proteins revealed impaired polyunsaturated fatty acid metabolism and GTP metabolism in brainstem of spontaneously hypertensive rats. Journal of Proteome Research, 2021. 20 (6) : 3305-3314. 4. W Zhou#, G Zeng#, C Lyu, F Kou, S Zhang*, H Wei*. The effect of strength-endurance training on serum and urine metabolic profiles of female adolescent volleyball athletes. Physiology International, 2021. 108(2): 285-302. 5. Fang Kou#, Bangjie Zhu#, Wenbin Zhou, Chunming Lv, Yu Cheng*, Hai Wei*. Targeted metabolomics reveals dynamic portrayal of amino acids and derivatives in triple-negative breast cancer cells and culture media. Molecular Omics, 2021, 17: 142-152. 6. Fang Kou#, Bangjie Zhu#, Wenbin Zhou, Chunming Lv, Yu Cheng*, Hai Wei*. Targeted metabolomics in the cell culture media reveals increased uptake of branched amino acids by breast cancer cells. Anal Biochem, 2021, 624: 114192. 7. Qiang Li#, Wenbin Zhou, Yuyan Wang, Fang Kou, Chunming Lyu*, Hai Wei*. Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sciences, 2020, 261:118433. 8. Wenbin Zhou#, Guigang Zeng#, Chunming Lyu, Fang Kou, Shen Zhang*, Hai Wei*. The effect of exhaustive exercise on plasma metabolic profiles of male and female rats. Journal of Sports Science & Medicine, 2019, 18(2): 253-263. 9. Chunming Lyu#, Yufeng Zhang, Wenbin Zhou, Shen Zhang, Fang Kou, Hai Wei*, Ning Zhang*, and Zhong Zuo*. Gender-dependent pharmacokinetics of veratramine in rats: in vivo and in vitro evidence The AAPS Journal, 2016, 18(2): 432-444. 10. Chunming Lyu#, Wenbin Zhou, Yufeng Zhang, Shen Zhang, Fang Kou, Hai Wei*, Ning Zhang*, and Zhong Zuo*. Identification and characterization of in vitro and in vivo metabolites of steroidal alkaloid veratramine. Biopharmaceutics & Drug Disposition, 2015, 36(5): 308-324. 11.Wenbin Zhou#, Bangjie Zhu, Feng Liu, Chunming Lyu, Shen Zhang, Chao Yan, Yu Cheng*, Hai Wei*. A rapid and simple method for the simultaneous determination of four endogenous monoamine neurotransmitters in rat brain using hydrophilic interaction liquid chromatography coupled with atmospheric-pressure chemical ionization tandem mass spectrometry. Journal of Chromatography B, 2015, 1002: 379-386. 12.Hai Wei*, Weizhong Zheng, James Diakur, Leonard I. Wiebe. Confocal laser scanning microscopy (CLSM) based evidence for cell permeation by mono-4-(N-6-deoxy-6-amino_cyclodextrin)-7-nitrobenzofuran (NBD-CyD). International Journal of Pharmaceutics, 2011, 403:15-22. 13.Hai Wei#, Chad Dalton, Marie Di Maso, Isadore Kanfer, Raimar Löbenberg*. Physicochemical characterization of five glyburide powders: A BCS based approach to predict oral absorption. European Journal of Pharmaceutics and Biopharmaceutics, 2008, 69: 1046-1056. 14.Hai Wei#, Raimar Löbenberg*. Biorelevant dissolution media as a predictive tool for glyburide a class II drug. European Journal of Pharmaceutical Sciences, 2006, 29: 45-52.