Marlow, Maria - University of Nottingham

个人简介

I am pharmacist with a PhD in drug delivery (University of Nottingham 1991) and post doctoral experience in tissue engineering (Massachusetts Institute of Technology 1991-1992) working with osteoblasts and biodegradable polymers. I have over 18 years experience in drug delivery in industry and have worked on many different drug delivery options and formulations throughout my career at Fisons, Astra and then AstraZeneca including oral, intravenous and inhaled dosage forms. Specifically I worked on AstraZeneca's metered dose inhaler SYMBICORT, for which I have a formulation patent. I have also developed formulations of poorly soluble candidate drugs. My industrial experience includes several scientific and line manager roles from 1996 leading multidisciplinary teams in product development and early development. My most recent industrial role in early development included the development of formulations for preclinical, toxicity and phase I/II studies. I have also project managed and led numerous technical improvement projects/teams including recently in 2010, the development of a new global process for suspension development and a global web based brochure for clinical supplies. In May 2011, I made the transition back into academia and secured the first Gunn and Carter Senior Fellowship at De Montfort University working with Dr Geoff Smith on developing methodologies for studying bio-relevant physical form changes of drug substances and drug products using terahertz spectroscopy and pulsed imaging. In Jan 2012, I was appointed as Associate Professor in Formulation Science and Pharmaceutical Materials in the Drug Delivery and Tissue Engineering Group in the School of Pharmacy.

研究领域

My research interests are focused on developing drug delivery systems or diagnostics that address an unmet clinical need in collaboration with clinicians. My initial research focus will be the self -assembly of prodrugs, hydrogels or microparticles particularly for localised or intratumoral delivery in cancer therapy, improving upon the therapeutic outcomes of existing drugs. The research will involve the physicochemical characterisation of these deliver systems to allow the prediction of their in vivo performance. I am also interested in collaborations where my industrial experience and formulation knowledge can be utilised in the formulation of inhaled therapeutics and poorly soluble drugs.

近期论文

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YAŞAYAN G, XUE X, COLLIER P, CLARKE P, ALEXANDER MR and MARLOW M, 2016. The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment. Nanotechnology. 27(25), 255102 ANGELEROU MG, SABRI A, CREASEY R, ANGELEROU P, MARLOW M and ZELZER M, 2016. Surface-directed modulation of supramolecular gel properties. Chemical communications (Cambridge, England). 52(23), 4298-300 2016. Linking In Vitro Lipolysis and Microsomal Metabolism for the Quantitative Prediction of Oral Bioavailability of BCS II Drugs Administered in Lipidic Formulations. Molecular pharmaceutics. (In Press.) MARLOW, MARIA, AL-AMEEDEE, MOHAMMED, SMITH, THOMAS, WHEELER, SIMON and STOCKS, MICHAEL J., 2015. Linifanib - a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator CHEMICAL COMMUNICATIONS. 51(29), 6384-6387 P. BENITO-GALLO, P. GERSHKOVICH, M. MARLOW, V. ZANN and K.M. WASAN, 2015. Smart Lipid-Based Drug Delivery Systems. In: V.P. TORCHILIN, ed., Smart Pharmaceutical Nanocarriers Imperial College Press. (In Press.) BENITO-GALLO, PALOMA, FRANCESCHETTO, ALESSANDRO, WONG, JONATHAN C. M., MARLOW, MARIA, ZANN, VANESSA, SCHOLES, PETER and GERSHKOVICH, PAVEL, 2015. Chain length affects pancreatic lipase activity and the extent and pH-time profile of triglyceride lipolysis EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 93, 353-362 STONE, ERICA L., CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B., MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F.G., LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D., 2015. Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery: Bioorganic & Medicinal Chemistry Bioorganic & Medicinal Chemistry. 23, 6891-6899 SKILLING, K. J., NDUNGU, A., KELLAM, B., ASHFORD, M., BRADSHAW, T. D. and MARLOW, M., 2014. Gelation properties of self-assembling N-acyl modified cytidine derivatives JOURNAL OF MATERIALS CHEMISTRY B. 2(47), 8412-8417 K. J. SKILLING, F. CITOSSI, T. D. BRADSHAW, M. ASHFORD, B. KELLAM and M. MARLOW, 2013. Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications SOFT MATTER. 10(2), 237-256 MAHBOUBIAN, A, STOLNIK, S, ARSHAD, S., MARLOW, ME and SIMTH, G, 2012. In: Drug Delivery: Through the ages. United Kingdom & Ireland Controlled Release Society: Birmingham, UK. p. 53.: Evaluating in-situ Gelation using Terahertz and Dielectric Spectroscopy, GOVIND, NAYNA and MARLOW, MARIA, 2010. The invention relates to a formulation comprising formoterol and budesonide: for use in the treatment of respiratory diseases US 7,759,328 07/20/2010 00:00:00 DAVIES, M.J., BRINDLEY, A., CHEN, X., DOUGHTY, S.W., MARLOW, M. and ROBERTS, C.J., 2009. A quantitative assessment of inhaled drug particle-pulmonary surfactant interaction by atomic force microscopy Colloids and Surfaces. B, Biointerfaces. 73(1), 97-102 DAVIES, O.R., HEAD, L., ARMITAGE, D., PEARSON, E.A., DAVIES, M.C., MARLOW, M. and STOLNIK, S., 2008. Surface modification of microspheres with steric stabilising and cationic polymers for gene delivery Langmuir. 24, 7138-7146 DAVIES, OR, MARLOW, M and STOLNIK, S, 2008. Macroporous Surface Modified Microparticles Soft Matter. 4(8), 1597-1601