Scott, Dave - University of Nottingham

个人简介

2015 Elected Fellow of the Royal Society of Biology 2012-present: STFC Senior Molecular Biology and Neutron Fellow 2012-present: Group Leader in Biophysical Methods in the Research Complex at Harwell. 2011-present: Associate Professor and Reader in Physical Biochemistry. 2009-2011: Associate Professor in Physical Biochemistry, University of Nottingham and Deputy Director of the National Centre for Macromolecular Hydrodynamics, University of Nottingham. 2003-2009: Lecturer in Physical Biochemistry. University of Nottingham. 2001-2003: Post-doctoral research associate. Department of Biochemistry, University of Bristol. I worked for Prof. SteveHalford on a Wellcome funded programme grant to study the mechanism of Type II restriction enzymes that require one and two DNA binding sites. 2000-2001: Post-doctoral research assistant, Oxford Centre for Molecular Sciences, University of Oxford/YSBL, Department of Chemistry, University of York. For this year I worked 50 % of the time in the laboratory of Prof. Carol Robinson at Oxfordanalysing non-covalent macromolecular complex formation using nanospray mass spectrometry. The rest of the time I continued to work in the YSBL. 1999-2000: Post-doctoral research assistant, York Structural Biology Laboratory, Departments of Chemistry and of Biology, University of York. BBSRC funded position in the YSBL. I was involved in developing biophysical techniques such as analytical ultracentrifugation, isothermal titration calorimetry and small angle scattering. 1996-1999: Post-doctoral research assistant, Department of Biology, University of York. BBSRC 3 year project grant working for Dr. Jim Hoggett on interactions of sigmaN with E. coli RNA polymerase using novel tryptophan analogues. Graduate and Undergraduate Studies 1992-1996: Postgraduate, Department of Biology, University of Leeds. PhD Thesis: "Kinetic analysis of bacteriophage MS2 self-assembly", supervised by Prof. Peter Stockley. 1989-1992: Undergraduate, Department of Biochemistry and Molecular Biology, University of Leeds. BSc Molecular Biophysics

近期论文

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GREEN, M., HATTER, L., BROOKES, E., SOULTANAS, P. and SCOTT, D.J., 2016. Defining the Intrinsically Disordered C-terminal Domain of SSB Reveals DNA-mediated Compaction Journal of Molecular Biology. 428, 357-364 ASIANI, K.R., WILLIAMS, H., BIRD, L., JENNER, M., SEARLE, M.S., HOBMAN, J.L., SCOTT, D.J. and SOULTANAS, P., 2016. SilE is an intrinsically disordered periplasmic ‘molecular sponge’ involved in bacterial silver resistance Molecular Microbiology. 101(5), 731-742 RAJASEKAR KV, LOVERING AL, DANCEA F, SCOTT DJ, HARRIS SA, BINGLE LE, ROESSLE M, THOMAS CM, HYDE EI and WHITE SA, 2016. Flexibility of KorA, a plasmid-encoded, global transcription regulator, in the presence and the absence of its operator. Nucleic acids research. 44(10), 4947-56 ZHAO H, GHIRLANDO R, ALFONSO C, ARISAKA F, ATTALI I, BAIN DL, BAKHTINA MM, BECKER DF, BEDWELL GJ, BEKDEMIR A, BESONG TMD, BIRCK C, BRAUTIGAM CA, BRENNERMAN W, BYRON O, BZOWSKA A, CHAIRES JB, CHATON CT, C?LFEN H, CONNAGHAN KD, CROWLEY KA, CURTH U, DAVITER T, DEAN WL, DíEZ AI, EBEL C, ECKERT DM, EISELE LE, EISENSTEIN E, ENGLAND P, ESCALANTE C, FAGAN JA, FAIRMAN R, FINN RM, FISCHLE W, DE LA TORRE JG, GOR J, GUSTAFSSON H, HALL D, HARDING SE, CIFRE JGH, HERR AB, HOWELL EE, ISAAC RS, JAO S, JOSE D, KIM S, KOKONA B, KORNBLATT JA, KOSEK D, KRAYUKHINA E, KRZIZIKE D, KUSZNIR EA, KWON H, LARSON A, LAUE TM, LE ROY A, LEECH AP, LILIE H, LUGER K, LUQUE-ORTEGA JR, MA J, MAY CA, MAYNARD EL, MODRAK-WOJCIK A, MOK Y, MüCKE N, NAGEL-STEGER L, NARLIKAR GJ, NODA M, NOURSE A, OBSIL T, PARK CK, PARK J, PAWELEK PD, PERDUE EE, PERKINS SJ, PERUGINI MA, PETERSON CL, PEVERELLI MG, PISZCZEK G, PRAG G, PREVELIGE PE, RAYNAL BDE, REZABKOVA L, RICHTER K, RINGEL AE, ROSENBERG R, ROWE AJ, RUFER AC, SCOTT DJ, SERAVALLI JG, SOLOVYOVA AS, SONG R, STAUNTON D, STODDARD C, STOTT K, STRAUSS HM, STREICHER WW, SUMIDA JP, SWYGERT SG, SZCZEPANOWSKI RH, TESSMER I, TOTH RT, TRIPATHY A, UCHIYAMA S, UEBEL SFW, UNZAI S, GRUBER AV, VON HIPPEL PH, WANDREY C, WANG S, WEITZEL SE, WIELGUS-KUTROWSKA B, WOLBERGER C, WOLFF M, WRIGHT E, WU Y, WUBBEN JM and SCHUCK P, 2015. A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. PLOS ONE. 10(5), e0126420 GREEN M, HATTER L, BROOKES E, SOULTANAS P and SCOTT DJ, 2015. Defining the Intrinsically Disordered C-Terminal Domain of SSB Reveals DNA-Mediated Compaction. Journal of molecular biology. 428(2 Pt A), 357-64 ARENA DE SOUZA V, SCOTT DJ, NETTLESHIP JE, RAHMAN N, CHARLTON MH, WALSH MA and OWENS RJ, 2015. Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1. PloS one. 10(12), e0143919 PATEL TR, WINZOR DJ and SCOTT DJ, 2015. Analytical ultracentrifugation: A versatile tool for the characterisation of macromolecular complexes in solution. Methods (San Diego, Calif.). 95, 55-61 SCOTT DJ and WINZOR DJ, 2015. Characterization of Intrinsically Disordered Proteins by Analytical Ultracentrifugation. Methods in enzymology. 562, 225-39 HARPER S, GRATTON HE, CORNACIU I, OBERER M, SCOTT DJ, EMSLEY J and DREVENY I, 2014. Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains. Biochemistry. 53(18), 2966-78 SCOTT, D.J., HARDING, S.E. and WINZOR, D.J., 2014. Concentration dependence of translational diffusion coefficients for globular proteins Analyst. 139, 6242-6248 PORTMAN, KATHERINE L., LONG, JED, CARR, STEPHEN, BRIAND, LOIC, WINZOR, DONALD J., SEARLE, MARK S. and SCOTT, DAVID J., 2014. Enthalpy/Entropy Compensation Effects from Cavity Desolvation Underpin Broad Ligand Binding Selectivity for Rat Odorant Binding Protein 3 BIOCHEMISTRY. 53(14), 2371-2379 SCOTT DJ, HARDING SE and WINZOR DJ, 2014. Concentration dependence of translational diffusion coefficients for globular proteins. The Analyst. 139(23), 6242-8 TREVITT CR, HOSSZU LL, BATCHELOR M, PANICO S, TERRY C, NICOLL AJ, RISSE E, TAYLOR WA, SANDBERG MK, AL-DOUJAILY H, LINEHAN JM, SAIBIL HR, SCOTT DJ, COLLINGE J, WALTHO JP and CLARKE AR, 2014. N-terminal domain of prion protein directs its oligomeric association. The Journal of biological chemistry. 289(37), 25497-508 HEWITT D, MARKLUND E, SCOTT DJ, ROBINSON CV and BORYSIK AJ, 2014. A hydrodynamic comparison of solution and gas phase proteins and their complexes. The journal of physical chemistry. B. 118(29), 8489-95 PINFIELD VJ and SCOTT DJ, 2014. Anomalous small angle x-ray scattering simulations: proof of concept for distance measurements for nanoparticle-labelled biomacromolecules in solution. PloS one. 9(4), e95664 PORTMAN KL, LONG J, CARR S, BRIAND L, WINZOR DJ, SEARLE MS and SCOTT DJ, 2014. Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3. Biochemistry. 53(14), 2371-9 FURSE, SAMUEL, LIDDELL, SUSAN, ORTORI, CATHARINE, WILLIAMS, HUW, NEYLON, D.CAMERON, SCOTT, DAVID, BARRETT, DAVID and GRAY, DAVID, 2013. The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower) J Biological Chemistry. 6(2), 63-76 ROY R, USHA V, KERMANI A, SCOTT DJ, HYDE EI, BESRA GS, ALDERWICK LJ and FüTTERER K, 2013. Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2. ACS chemical biology. 8(10), 2245-55 NETTLESHIP JE, REN J, SCOTT DJ, RAHMAN N, HATHERLEY D, ZHAO Y, STUART DI, BARCLAY AN and OWENS RJ, 2013. Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment. BMC structural biology. 13, 13 SCOTT DJ, PATEL TR and WINZOR DJ, 2013. A potential for overestimating the absolute magnitudes of second virial coefficients by small-angle X-ray scattering. Analytical biochemistry. 435(2), 159-65 SCOTT DJ and WINZOR DJ, 2012. Sedimentation Velocity Of Intrinsically Disordered Proteins: What Information Can We Actually Obtain? Molecular Biosystems. 8(1), 378-80 WILLS PR, SCOTT DJ and WINZOR DJ, 2012. Allowance For Effects Of Thermodynamic Nonideality In Sedimentation Equilibrium Distributions Reflecting Protein Dimerization. Analytical Biochemistry. 422(1), 28-32 BEEVERS AJ, NASH A, SALAZAR-CANCINO M, SCOTT DJ, NOTMAN R and DIXON AM, 2012. Effects Of The Oncogenic V(664)E Mutation On Membrane Insertion, Structure, And Sequence-Dependent Interactions Of The Neu Transmembrane Domain In Micelles And Model Membranes: An Integrated Biophysical And Simulation Study. Biochemistry. 51(12), 2558-68 HARPER, S., BESONG, T.M.D., EMSLEY, J., SCOTT, D.J. and DREVENY, I., 2011. Structure of the USP15 N-terminal domains: a β-hairpin mediates close association between the DUSP and UBL domains Biochemistry. 50(37), 7995-8004 SCHR?DER S, FRATERNALI F, QUAN X, SCOTT D, QIAN F and PFUHL M, 2011. When A Module Is Not A Domain: The Case Of The Rej Module And The Redefinition Of The Architecture Of Polycystin-1. The Biochemical Journal. 435(3), 651-60