Wyatt, Sean - Cardiff University - School of Biosciences

研究领域

My lab investigates how Neurotrophic Factors regulate the functional properties of primary sensory neurons of the adult Dorsal Root Ganglion. In particular, we use a variety of techniques to investigate the potentially novel neurotrophic effects on adult DRG neurons of molecules that have trophic effects in other organ/tissue systems.

近期论文

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Harvey, A.et al. 2016. Novel application of behavioral assays allows dissociation of joint pathology from systemic extra-articular alterations induced by inflammatory arthritis. Journal of Rheumatic Diseases and Treatment 2(1), article number: 033. pdf O'Keeffe, G.et al. 2016. Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation. Neural Development 11, article number: 4. (10.1186/s13064-016-0060-3) pdf Vizard, T.et al. 2015. ERK signaling mediates CaSR-promoted axon growth. Neuroscience Letters 603, pp. 77-83. (10.1016/j.neulet.2015.07.019) pdf McWilliams, T.et al. 2015. Regulation of autocrine signaling in subsets of sympathetic neurons has regional effects on tissue innervation. Cell Reports 10(9), pp. 1443-1449. (10.1016/j.celrep.2015.02.016) pdf Walsh, S.et al. 2015. Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease. International Journal of Neuroscience 125(1), pp. 70-77. (10.3109/00207454.2014.904304) Nolan, A.et al. 2014. The neurite growth inhibitory effects of soluble TNFα on developing sympathetic neurons are dependent on developmental age. Differentiation 88(4-5), pp. 124-130. (10.1016/j.diff.2014.12.006) Osório, C.et al. 2014. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. Molecular and Cellular Neuroscience 59, pp. 24-36. (10.1016/j.mcn.2014.01.002) pdf Gavin, A.et al. 2014. 6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo. Neuroscience Letters 561, pp. 176-181. (10.1016/j.neulet.2013.12.046) Hegarty, S.et al. 2014. Canonical BMP–Smad signalling promotes neurite growth in rat midbrain dopaminergic neurons. NeuroMolecular Medicine 16(2), pp. 473-489., article number: 10.1007/s12017-014-8299-5. (10.1007/s12017-014-8299-5) Collins, L.et al. 2014. Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease. SpringerPlus 3(1), article number: 205. (10.1186/2193-1801-3-205) pdf