Eberl, Matthias - Cardiff University

个人简介

since 08/2015 Reader, Division of Infection & Immunity, School of Medicine, Cardiff University 2011-2015 Senior Lecturer, Cardiff Institute of Infection & Immunity, School of Medicine, Cardiff University 2007-2011 RCUK Fellow in Translational Research, School of Medicine, Cardiff University 2005-2006 Postdoc, Institute of Cell Biology, University of Bern (Switzerland) Lab: Prof Bernhard Moser 2000-2005 Postdoc, Institute of Biochemistry, School of Medicine, University of Giessen (Germany) Lab: Dr Hassan Jomaa 1998-2000 Postdoc, Department of Biology, University of York (UK) Lab: Prof Alan Wilson 1995-1998 PhD Student, Institute of Biochemistry, School of Medicine, University of Giessen (Germany) Lab: Prof Ewald Beck

研究领域

I have always been interested in the molecular and cellular basis of host-pathogen relationships and the underlying modulation of complex immune responses. During my PhD I established a screening method to identify CD4+ T cell antigens from cDNA libraries of the parasite Schistosoma mansoni. I then extended these studies during a two-year postdoc, and investigated the cellular and humoral immune response to schistosomes upon infection and vaccination. My research since 2000 has concentrated on defining the role of human γδ T cells in bridging innate and adaptive immune responses. γδ T cells are the prototype of 'unconventional' lymphocytes in that they are not restricted by classical MHC and display characteristics of 'conventional' T cells, NK cells and myeloid cells. Normally only constituting a minor population in human blood, they occupy a unique niche in microbial recognition and contribute to tumour surveillance. More recently we have started to characterise early immune responses in acutely infected patients and define pathogen-specific signatures of cellular and soluble biomarkers ('immune fingerprints'). My research is placed at the interface of basic, translational and clinical research and benefits greatly from interdisciplinary collaborations with immunologists, microbiologists, biochemists, epidemiologists and clinicians. Besides implications for diagnosis and treatment of microbial infections this work has direct consequences for vaccine design and cancer immunotherapy.

近期论文

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Liuzzi, A.et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990) pdf Raby, A.et al. 2016. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology (10.1681/ASN.2015080923) Johansson, M.et al. 2016. Probiotic lactobacilli modulate staphylococcus aureus-induced activation of conventional and unconventional T cells and NK cells. Frontiers in Immunology 7, article number: 00273. (10.3389/fimmu.2016.00273) pdf Morgan, M.et al. 2016. Sepsis patients with first and second-hit infections show different outcomes depending on the causative organism. Frontiers in Microbiology 7, article number: 207. (10.3389/fmicb.2016.00207) pdf Raby, A.et al. 2016. Toll-like receptors 2 and 4 are potential therapeutic targets against peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology pdf Liuzzi, A.et al. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36, pp. 31-37. (10.1016/j.coi.2015.06.002) pdf Piggott, L.et al. 2015. Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 17(1), pp. 96. (10.1186/s13058-015-0597-9) pdf Tyler, C.et al. 2015. Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system. Cellular Immunology 296(1), pp. 10-21. (10.1016/j.cellimm.2015.01.008) Bonneville, M.et al. 2015. Chicago 2014 – 30 years of γδ T cells. Cellular Immunology 296(1), pp. 3-9. (10.1016/j.cellimm.2014.11.001) Rhodes, D.et al. 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. The Journal of Immunology 194(5), pp. 2390-2398. (10.4049/jimmunol.1401064) Tyler, C. J., Moser, B. and Eberl, M. 2014. Gamma delta T-APCs promote IL-22 responses in naive and memory CD4(+) T-cells. Immunology 143, pp. 116-117. Khan, M., Eberl, M. and Moser, B. 2014. Potential use of γδ T-cell-based vaccines in cancer immunotherapy. Frontiers in Immunology 5, pp. 1-5., article number: 512. (10.3389/fimmu.2014.00512)