Sewell, Robert - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

Robert Sewell graduated in pharmacy at the University of Bradford (B.Pharm) and became a registered pharmacist (M.R.Pharm.S). After a period in clinical pharmacy practice, Professor Sewell undertook research training in experimental applied pharmacology at the University of Wales Institute of Science and Technology (UWIST). His research was carried out in the laboratory of Prof. Paul Spencer on a Scholarship awarded by C. H. Boehringer Sohn and he was awarded Ph.D in 1976 for studies on Opioid Receptor Classification and Modified Neurotransmitter Function. Professor Sewell was appointed as a lecturer in Pharmacology at UWIST in 1976 and spent a sabbatical period as a Heritage funded research scientist (1982 -1984) with Prof. Sheldon Roth in the Department of Pharmacology and Prof. Leo Strunin, Department of Anaesthesiology at the University of Calgary Medical School. Subsequently, he also spent collaborative periods with Prof. Bernard Roques from the Université René Descartes, Paris and Prof. Juan Mico from the Department of Pharmacology and Psychiatry at the School of Medicine, University of Cadiz. Professor Sewell was appointed Senior Lecturer in Pharmacology at the School of Pharmacy and Pharmaceutical Sciences, Cardiff University in 1987 and then became Director of Postgraduate Studies (Clinical Research) in 1996. More recently, he has had research collaborations with Dr Marina Gruden at the P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow and with Prof Ludmilla Morozova-Roche at the Department of Medical Biochemistry and Biophysics, Umeå University, Sweden. He was promoted to Reader in Pharmacology in 2010, and promoted again to Professor of Pharmacology in 2013. He was designated a Fellow of the Royal Pharmaceutical Society of Great Britain in June 2009.

研究领域

Drug Dependence and Tolerance Mechanisms of Neurodegeneration and drug actions on memory Computer Assisted Learning (CAL) Professor Sewell commenced his research career as an opioid neuropharmacologist studying analgesia, tolerance and dependence. He later developed an interest in non-receptor mediated membrane actions of benzodiazepines and consequently spent two years in Canada exploring this field of research. On return to the U.K, he became involved with studies on cotton contamination and its relevance to occupational lung disease but subsequently, he has focused on neurodegenerative diseases, early biomarkers of cognitive decline, memory enhancement and the development of neuroprotective agents. He has continually maintained a lasting interest in opioid dependence studies both at the clinical and experimental level. Throughout, Professor Sewell has recognised the importance of teaching research particularly in the use of computers in the learning environment. He has taken an active role in the development of teaching packages for Pharmacy and Pharmacology students within the Pharmacy Consortium for Computer Aided Learning (PCCAL) since the early 1990s and he has numerous publications in the context of teaching research.

近期论文

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Alam, J.et al. 2017. Synthetic and natural antioxidants attenuate cisplatin-induced vomiting. BMC Pharmacology and Toxicology 18(4) (10.1186/s40360-016-0110-9) pdf Ayaz, M.et al. 2017. Cellular efflux transporters and the potential role of natural products in combating efflux mediated drug resistance. Frontiers in Bioscience 22(4), pp. 732-756. (10.2741/4513) pdf Shahid, M.et al. 2016. Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. European Journal of Pain (10.1002/ejp.971) pdf Aman, U.et al. 2016. Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms. BMC Complementary and Alternative Medicine 16(1), article number: 77. (10.1186/s12906-016-1048-6) pdf Gruden, M.et al. 2016. The misfolded pro-inflammatory protein S100A9 disrupts memory via neurochemical remodelling instigating an Alzheimer's disease-like cognitive deficit. Behavioural Brain Research 306, pp. 106-116. (10.1016/j.bbr.2016.03.016) pdf Khan, M.et al. 2015. Thymoquinone inhibition of acquisition and expression of alcohol-induced behavioral sensitization. Phytotherapy Research 29(10), pp. 1610-1615. (10.1002/ptr.5409) pdf Ali, G.et al. 2015. A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. Naunyn Schmiedeburgs Archives of Pharmacology , pp. 1-12. (10.1007/s00210-015-1145-y) pdf