Pedersen, Irene - University of California, Irvine - Department of Molecular Biology and Biochemistry

研究领域

The recent discovery of microRNAs (miRs) has revolutionized our understanding of gene control. miRs are encoded by endogenous genes and regulate over half of all genes in mammalian cells. They regulate gene expression at the stages of translation and mRNA stability. Already there is evidence that specific miRs play key roles in controlling development, stem cell fates and differentiation, and mutations in human miR genes have been linked to oncogenic and other disease states. An important task is to unveil the functions of individual miRs, determine how the miRs themselves are regulated and elucidate their role in normal cell homeostasis and human diseases. The main focus of my laboratory is to investigate the role of specific miRs (identified from miR/amiR screens) in normal cells including during induces pluripotent stem cell (iPSC)-development, and explore how to regulate/counteract such dysregulation in a diseased state (cancer, neurological disorders). A second area of research interest of my laboratory is to elucidate miRs function as a novel restriction mechanism against retroviral elements (LINE-1, hERVs and HIV-1) in human cells.

近期论文

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Hamdorf M, Idica A, Zisoulis DG, Gamelin L, Martin C, Sanders K, and Pedersen IM, 2015, miR-128 represses retrotransposition by directly binding to L1 RNA, Nat. Struct. Mol. Biol, 22:824-31, PMID:26367248 Spitale RC, Plikus MV and Pedersen IM., 2015, The emerging functions of regulatory RNA species in skin stem cells and regeneration, Exp Dermatol, 24:827-8. PMID:26309056 Pedersen IM and Zisoulis DG, Transposable elements and miRNA: Regulation of Genomic Stability and Plasticity, Mobile Genetic Elements, 2016, 6(3):e1175537. PMID:27511122 Rieß M, Hein-Fuchs N, Idica A, Hamdorf M, Flory E, Pedersen IM and König R, Interferons Induce Expression of SAMHD1 in Monocytes through Downregulation of miR-181a and miR-30a, J. Biol. Chem, 2017, 292:264-277. PMID:27909056 Miletic AV*, Anzelon-Mills A*, Omori S, Pedersen IM, Shin D, Ravetch JV, Bolland S, Morse S and Rickert R: Coordinate Suppression of B Cell Lymphoma by PTEN and SHIP Phosphatases, J. Exp. Med., 2010, 207:2407-20 Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, Ciarlariello D, Neviani P, Harb J, Kauffman LR, Shidham A, Croce CM., Ship and C/ebp{beta} are targeted by miR-155 in B cells of E{micro}-miR-155 transgenic mice., Blood, 2009, 114:1374-82 Pedersen IM, Otero D., Kao, E., Miletec A, Hother S. Ralfkiaer E, Rickert RC, Gronbeck K, David M, Onco-miR-155 targets SHIP to promote TNFa-dependent growth of B cell lymphomas, EMBO Mol. Med., 2009, 1:288-295. Pedersen IM & David M., microRNAs in the immune response, Cytokine, 2008, 43:391-4. Pedersen IM. and Reed JC., Microenvironmental interactions and survival of CLL B-cells., Leuk Lymphoma, 2004, 45:2365-72. Pedersen IM, Wieland S, Cheng G, Violinia S, Croce CM, Chisari FV & David M., Interferon modulation of cellular miRs as a novel anti-viral mechanism, Nature, 2007, 449:919-22.