Zaragoza, Michael - University of California, Irvine - Department of Biological Chemistry

个人简介

1987-1992 University of California at Berkeley, BA in Biophysics-Medical Physics with honors, high distinction 1992 Phi Beta Kappa, UC, Berkeley 1992-2000 National Service Award Training Grant, MSTP, CWRU 2003 Pediatric Resident Teaching Award, UC Irvine Medical Center 2005 Outstanding Pediatric Fellow Award, UC Irvine Medical Center 2007 Faculty Career Development Award, UCI 2007, 2008, 2009 American Heart Association Undergraduate Student Research Program-Host Laboratory 2007, 2011, 2014 College of Medicine Committee on Research Award, University of California, Irvine- Award x3 2012 UCI Institute for Clinical & Translational Science (ICTS) Pilot Project Award 2012 2012 , 2013 Best 1st year Course Award, Medical Genetics Course Director, UCI SOM- Award x2 2012-2015 Excellence in Teaching Award, Office of Medical Education, UCI SOM- Award x4

研究领域

Inherited cardiovascular diseases including cardiomyopathies and arrhythmia are conditions with high morbidity and limited therapies. Cardiomyopathies are caused by defects in either structural or energetic components of heart cells which lead to muscle weakness and heart failure. Arrhythmia is an abnormal heart beat or rhythm caused by a change in the electrical signals of the heart that can result in sudden cardiac death. To investigate the specific molecular mechanisms in inherited cardiovascular diseases, the goal is to develop in vitro disease models directly from patients to assess the pathogenicity and mechanism of genetic mutations and modifiers.

近期论文

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Zaragoza MV, Jacobs PA, James RS, Rogan P, Sherman S, Hassold T. (1994) Nondisjunction of human acrocentric chromosomes:studies of 432 trisomic fetuses and liveborns. Hum Genet 94:411-417. Hassold T, Abruzzo M, Adkins K, Griffin D, Merrill M, Millie E, Saker D, Shen J, Zaragoza M. (1996) Human aneuploidy: incidence, origin and etiology. Environ Mol Mut 28:167-175. Keep D, Zaragoza MV, Hassold T, Redline RW. (1996) Very early complete hydatidiform mole. Hum Pathol 27:708-713. Zaragoza MV, Keep D, Genest DR, Hassold T, Redline RW. (1997) Early complete hydatidiform moles contain inner cell mass derivatives. Am J Med Genet 70:273-277. Griffin DK, Millie EA, Redline RW, Hassold TJ, Zaragoza MV. (1997) Cytogenetic analysis of spontaneous abortions: comparison of techniques and assessment of the incidence of confined placental mosaicism. Am J Med Genet 72:297-301. Redline RW, Hassold T, Zaragoza MV. (1998) Prevalence of the partial molar phenotype in triploidy of maternal and paternal origin. Hum Pathol 29:505-511. Redline RW, Hassold T, Zaragoza M. (1998) Determinants of villous trophoblastic hyperplasia in spontaneous abortions. Mod Pathol 11:762-768. Zaragoza MV, Millie E, Redline RW, Hassold TJ. (1998) Studies of non-disjunction in trisomies 2, 7, 15, and 22:does the parental origin of trisomy influence placental morphology? J Med Genet 35:924 931. Redline RW, Zaragoza M, Hassold T. (1999) Prevalence of developmental and inflammatory lesions in nonmolar first-trimester spontaneous abortions. Hum Pathol 30:93-100. Zaragoza MV, Millie E, Chakravarti A, Surti U, Redline RW, Hassold TJ. (2000) Origin and phenotype of triploidy in spontaneous abortions: predominance of diandry and its association with the partial hydatidiform mole. Am J Hum Genet. 66:1807-20. Zaragoza MV, Lewis LE, Wang E, Sun G, Li L, Said-Salman I, Feucht L, Huang T. (2004) Identification of the TBX5 transactivating domain and the nuclear localization signal.Gene 330:9-18. Pop, R, Zaragoza MV, Gaudette M, Bocian ME, Scherer G. (2005) A homozygous nonsense mutation in SOX9 in the dominant disorder campomelic dysplasia: a case of mitotic gene conversion. Hum Genet. 117:43-53.