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个人简介

2010年6月-2010年9月:美国得克萨斯大学西南医学中心访问教授。 2005年起: 中山大学化学与化工学院、中山医学院双聘教授。 2003年-2005年:美国凯斯西储大学研究人员。 2002年:德国马尔堡大学洪堡学者。 2001年:美国北卡州立大学访问学者。 1998年-2000年:中国科学院化学研究所副研究员 。 1986年-1996年:北京理工大学化学与材料学院学习, 获学士、硕士及博士学位。

研究领域

以聚合物纳米医学技术为平台的疾病(例如:肿瘤)诊断及治疗研究,主要涉及下述两个方面: 1. 肿瘤等疾病早期诊断纳米探针研究 2. 小分子药物及核酸药物(例 如:基因及siRNA)的靶向传输及控制释放研究。

近期论文

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1. J. Li, X. Yu, Y. Wang, Y. Yuan, Hong Xiao, D. Cheng, X. Shuai*, A reduction and pH dual-sensitive polymeric vector for long-circulating and tumor-targeted siRNA delivery, Adv. Mater. 2014, 26, 8217-8224. 2. T. Yin, P. Wang, J. Li, Y. Wang, B. Zheng, R. Zheng*, D. Cheng, X. Shuai*, Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes, Biomaterials 2014, 35, 5932-5943. 3. W. Chen, Y. Yuan, D. Cheng, J. Chen, L. Wang, X. Shuai*, Co-delivery of doxorubicin and siRNA with reduction and pH dual sensitive nanocarrier for synergistic cancer therapy, Small 2014, 10, 2678-2687. 4. C. Wu, J. Li, P. Pang, J. Liu, K. Zhu, D. Li, D. Cheng, J. Chen, X. Shuai*, Hong Shan*, Polymeric vector-mediated gene transfection of MSCs for dual bioluminescent and MRI tracking in vivo, Biomaterials 2014, 28, 8249-8260. 5. C. Qian, Y. Wang, Y. Chen, L. Zeng, Q. Zhang, X. Shuai*, K. Huang*, Suppression of pancreatic tumor growth by targeted arsenic delivery with anti-CD44v6 single chain antibody conjugated nanoparticles, Biomaterials2013, 34, 6175-6184. 6. T. Yin, P. Wang, J. Li, R. Zheng*, B Zheng, D. Cheng, R. Li, J. Lai, X. Shuai*, Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas, Biomaterials 2013, 34, 4532-4543. 7. Y. Guo, W. Chen, W. Wang, J. Shen*, R. Guo, F. Gong, S. Lin, D. Cheng, G. Chen*, X Shuai*, Simultaneous Diagnosis and Gene Therapy of Immuno-Rejection in Rat Allogeneic Heart Transplantation Model Using a T-Cell-Targeted Theranostic Nanosystem, ACS Nano 2012,6, 10646-10657. 8. W. Wang, D. Cheng, D. Cheng, F. Gong, X. Miao, X. Shuai*, Design of multifunctional micelle for tumor-targeted intracellular drug release and fluorescent imaging, Adv. Mater. 2012, 24, 115-120. 9. D. Cheng, N. Cao, J. Chen, X. Yu, X. Shuai*, Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat, Biomaterials 2012, 33, 1170-1179. 10. J. Dai, S. Lin, D. Cheng, S. Zou, X. Shuai*, Interlayer crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed intracellular drug release, Angew. Chem. Int. Ed. 2011, 50, 9404 -9408. 11. N. Cao, D. Cheng, S. Zou, H. Ai, J. Gao, X. Shuai*, The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells, Biomaterials 2011, 32, 2222-2232. 12. J. Dai, S. Zou, Y. Pei, D. Cheng, H. Ai, X. Shuai*, Polyethylenimine-grafted copolymer of poly(L-lysine) and poly(ethylene glycol) for gene delivery, Biomaterials 2011, 32, 1694-1705. 13. B. Liang, M. He, C. Chan, Y. Chen, X. Li, Y. Li, D. Zheng, M. Lin, H. Kung, X. Shuai*, Ying Peng*, The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat, Biomaterials2009, 30, 4014-4020. 14. G. Chen*, W. Chen, Z. Wu, R. Yuan, Hua Li, J. Gao, X. Shuai*, MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression, Biomaterials 2009, 30, 1962-1970. 15. N. Nasongkla†, X. Shuai†, H. Ai, B. Weinberg, J. Pink, D. Boothman, J. Gao*, cRGD-functionalized polymer micelles for targeted doxorubicin delivery, Angew. Chem. Int. Edi. 2004, 43, 6323-6327. (†equal contributors). 16. X. Shuai, H. Ai, N. Nasongkla, S. Kim, J. Gao, Micellar Carriers Based on Block Copolymers of Poly(e-caprolactone) and Poly(ethylene glycol) for Doxorubicin Delivery, J. Controlled Release 2004, 98, 415-426. 学术积累 发表SCI论文60余篇,他引1500余次。申请发明专利8项。近5年来10多次在国际、国内学术会议上作邀请报告。担任Biomaterials、 Macromolecules、Biomacromolecules等学术期刊审稿人,广东省药学会药物制剂专业委员会副主任委员 。中山大学“百人计划”第二层次引进人才,2005年入选教育部“新世纪优秀人才支持计划”, 2010年入选广东省高校“千百十工程”省级培养对象。

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