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个人简介

教育经历 1972年-1976年 学士 中国台湾 东海大学 生物学 1977年-1982年 博士 加拿大 加拿大英属哥伦比亚大学 群体遗传学 工作经历 1982年6月-1984年12月 美国 德克萨斯大学休斯顿健康中心 博士后 1985年1月-1986年7月 美国 威斯康辛大学麦迪逊分校 博士后 1986年8月-1990年8月 美国 罗彻斯特大学 助理教授 1990年9月-1991年6月 美国 罗彻斯特大学 副教授 1991年7月-1998年6月 美国 芝加哥大学 副教授 1998年7月-2006年6月 美国 芝加哥大学生态与进化系 系主任 1998年7月-2008年5月 美国 芝加哥大学 教授 2008年6月-2014年5月 中国 中国科学院北京基因组研究所 所长 2014年6月 至今 中国 中山大学生命科学学院 教授 2004年被评为台湾中研院院士

研究领域

体细胞突变与癌症的群体基因组学;果蝇物种形成的分子和群体遗传学研究;果蝇microRNAs进化基因组学与自然选择

近期论文

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Lu, J., Y. Fu, S. Kumar, Y. Shen, R. W. Carthew and C.-I Wu, 2008 Adaptive evolution of newly-ermged microRNA genes in Drosophila. Molec. Biol. Evol. 25: 929–938. Lu, J., Y. Shen, Q. Wu, S. Kumar, B. He, S. Shi, R. W. Carthew, S. Wang and C.-I Wu, 2008 The birth and death of microRNA genes in Drosophila. Nature Genetics 40: 351–355. Wang, H., Y. Fu, M. McPeek, X. Lu, S. Nuzhdin, A. Xu, M. Wu and C.-I Wu, 2008 Complex genetic interactions underlying expression differences between Drosophila races - Analysis of chromosome substitutions. Proc. Natl. Acad. Sci. 105: 6362–6367. Wu, C.-I, H. Wang, S. Ling and X. Lu, 2016 The Ecology and Evolution of Cancer–The ultra-microevolutionary process. Annu. Rev. Genet. 50: 15.1–15.23. Yu, L., G. D. Wang, J. Ruan, Y. B. Chen, C. P. Yang, X. Cao, H. Wu, Y. H. Liu, Z. L. Du, X. P. Wang, J. Yang, S. C. Cheng, L. Zhong, L. Wang, X. Wang, J. Y. Hu, L. Fang, B. Bai, K. L. Wang, N. Yuan, S. F. Wu, B. G. Li, J. G. Zhang, Y. Q. Yang, C. L. Zhang, Y. C. Long, H. S. Li, J. Y. Yang, D. M. Irwin, O. A. Ryder, Y. Li, C.-I Wu and Y. P. Zhang, 2016 Genomics analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation. Nat. Genet. 48(8): 947–952. Wang, K. L., S. J. Lai, X. X. Yang, T. Q. Zhu, X. M. Lu, C.-I Wu and J. Ruan, 2017 Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq. Nature Communications. 8: 15335. | DOI: 10.1038/ncomms15335 Chen, Y. X., D. Tong and C.-I Wu, 2017 A new formulation of random genetic drift and its application to the evolution of cell populations. Mol. Biol. Evol. 34(8). | doi:10.1093/molbev/msx161 Li, C. Y., Y. L. Hou, J. Xu, A. Q. Zhang, Z. Z. Liu, F. R. Qi, Z. Y. Yang, K. Chen, S. X. Liu, H. W. Huang, Q. F. Wang, J. H. Dong, C.-I Wu and X. M. Lu, 2017 A direct test of selection in cell populations using the diversity in gene expression within tumors. Mol. Biol. Evol. 34(7): 1730–1742. Chen, Y. X., H. J. Wen and C.-I Wu, 2017 A mathematical theory of the Transcription Repression (TR) therapy of cancer – Whether and how it may work. Oncotarget 8(24): 38642–38649. | doi: 10.18632/oncotarget.16957 Yang, M., Z. W. He, S. H. Shi and C.-I Wu, 2017 Can genomic data alone tell us whether speciation happened with gene flow? Molecular Ecology 6: 2845–2849. Yang, M., Z. W. He, Y. L. Huang, L. Lu, Y. B. Yan, L. Hong, H. Shen, Y. Liu, Q. Guo, L. Jiang, Y. W. Zhang, A. J. Greenberg, R. C. Zhou, X. J. Ge, C.-I Wu and S. H. Shi, 2017 The emergence of the hyper-invasive vine, Mikania micrantha (Asteraceae), via admixture and founder events inferred from population Transcriptomics. Molecular Ecology 26: 3405–3423. | DOI: 10.1111/mec.14124 Xu, S. H., Z. W. He, Z. X. Guo, Z. Zhang, G. J. Wyckoff, A. Greenberg, C.-I Wu and S. H. Shi, 2017 Genome-Wide Convergence during Evolution of Mangroves from Woody Plants. Mol. Biol. Evol. 34(4): 1008–1015. Xu, S. H., Z. W. He, Z. Zhang, Z. X. Guo, W. X. Guo, H. M. Lyu, J. F. Li, M. Yang, Z. L. Du, Y. L. Huang, R. C. Zhou, C. R. Zhong, D. E. Boufford, M. Lerdau, C.-I Wu, N. C. Duke and S. H. Shi, 2017 The origin, diversification and adaptation of a major mangrove clade (Rhizophoreae) revealed by whole genome sequencing. National Science Review 4: 721–734. Liufu, Z. Q., Y. X. Zhao, L. Guo, G. X. Miao, J. Xiao, Y. Lyu, Y. X. Chen, S. H. Shi, T. Tang and C.-I Wu, 2017 Redundant and incoherent regulations of multiple phenotypes suggest microRNAs' role in stability control. Genome Res. 27(10): 1665–1673. Zhao, Y. X., X. Shen, T. Tang and C.-I Wu, 2017 Weak Regulation of Many Targets Is Cumulatively Powerful—An Evolutionary Perspective on microRNA Functionality. Mol. Biol. Evol. 34(12): 3041. Xu, J., X. X. Peng, Y. X. Chen, Y. Z. Zhang, Q. Ma, L. Liang, A. C. Carter, X. M. Lu and C.-I Wu, 2017 Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity. Elife 6: e28070. | doi: 10.7554/eLife.28070. Wang, H. Y., Y. X. Chen, D. Tong, S. P. Ling, Z. Hu, Y. Tao, X. M. Lu and C.-I Wu, 2018 Is the evolution in tumors Darwinian or non-Darwinian? National Science Review 5(1): 15–17. Zhao, Y. X., P. Lin, Z. Q. Liufu, H. Yang, Y. Lyu, X. Shen, C.-I Wu and T. Tang, 2018 Regulation of Large Number of Weak Targets-New Insights from Twin-microRNAs. Genome Biol. Evol. 10(5): 1255–1264. Lu, G. G., Y. X. Zhao, Z. Q. Liufu and C.-I Wu, 2018 On the possibility of death of new genes – evidence from the deletion of de novo microRNAs. BMC Genomics 19(1): 388. Lu, G. G., Y. X. Zhao, H. Yang, A. Lan, S. H. Shi, Z. Q. Liufu, Y. Huang, T. Tang, J. Xu, X. Shen and C.-I Wu, 2018 Death of new microRNA genes in Drosophila via gradual loss of fitness advantages. Genome Res. 28(9): 1309–1318.

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