黄亿华 - 中国科学院生物物理研究所 -

个人简介

1990-1995 北京大学生命科学学院，获理学学士学位 1995-1998 北京大学生命科学学院，获理学硕士学位 1998-2004 美国康奈尔大学医学院生物化学系，获博士学位 2004-2010 美国德州大学西南医学中心/霍华德休斯医学研究所博士后、研究助理和讲师 2011-今中国科学院生物物理研究所，研究员

研究领域

膜蛋白的生成与蛋白质的跨膜转运机理；生物膜的生成

近期论文

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Yanlong Xin, Yan Zhao, Jiangge Zheng, Haizhen Zhou, XuejunCai Zhang, Changlin Tian(*), and Yihua Huang*.（2017）Structure of YidC from Thermotogamaritima and its implications forYidC-mediated membrane protein insertion . FASEB J. Accepted. Qingshan Luo , Xu Yang , Shan Yu , Huigang Shi , Kun Wang , Le Xiao , Guangyu Zhu , Chuanqi Sun ,Tingting Li , Dianfan Li , Xinzheng Zhang , Min Zhou &Yihua Huang*.（2017）Structural basis for lipopolysaccharide extractioby ABC transporter LptB2FG. Nat StructMol Biol. May;24（5）:469-74 Han L, Zheng J, Wang Y, Yang X, Liu Y, Sun C, Cao B, Zhou H, Ni D, Lou J, Zhao Y, Huang Y*. （2016）Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins. Nat Struct Mol Biol. Mar; 23（3）:192-6 Yan Wang, Archana AndolePannuri, Dongchun Ni, Haizhen Zhou, Xiou Cao, Xiaomei Lu, Tony Romeo & Yihua Huang. (2016) Structural basis for translocation of a biofilm-supporting exopolysaccharide across the bacterial outer membrane. J. Biol. Chem 291(19):10046-57 Ni D, Huang Y*. （2015）The Expression, Purification, and Structure Determination of BamA from E. coli. Methods Mol Biol. 1329:169-78. Shuai Qiao., Qingshan Luo., Yan Zhao., Xuejun Cai Zhang. & Yihua Huang. (2014) Structural basis for lipopolysaccharide insertion in the bacterial outer membrane. Nature, 511(7507):108–111. Baohua Cao.,Yan Zhao.,Yongjun Kou.,Dongchun Ni.,Xuejun Cai Zhang. & Yihua Huang. (2014) Structure of the nonameric bacterial amyloidsecretionchannel. PNAS, 111(50):E5439-44. Dongchun Ni.,Yan Wang.,Xu Yang., Haizhen Zhou.,Xiaomin Hou.,Baohua Cao.,Zhixin Lu., Xinsheng Zhao., Kun Yang. & Yihua Huang.(2014) Structural and functional analysis of the β-barrel domain of BamA from Escherichia coli. The FASEB Journal, 28(6):2677-85. Huang Y., Smith B.,Chen L.,Baxter R.& Deisenhofer J.(2009) Insights into pilus　assembly and secretion from the structure and functional characterization of usher PapC. PNAS, 106(18):7403-7. Huang Y., Baxter R., Smith B.S., Partch C.L., Colbert C.L.& Deisenhofer J.(2006)　Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implication for　photolyase activity. PNAS, 103(47):17701-6. Huang Y., Lu M.& Wu H.(2004) Antagonizing XIAP-mediated caspase-3 inhibition:　Achilles' heel of cancers? Cancer Cell. 5(1):1-2 Huang Y., Rich R., Myszkat D.& Wu H.(2003) Requirement of both the second and　third BIR domains for the　relief　of　X-linked　inhibitor　of　apoptosis　protein　(XIAP)-mediated caspase inhibition by Smac. J. Biol. Chem. 278(49):49517-22 Huang Y., Park Y.C., Rich R.L., Segal D., Myszka D. G.& Wu H.(2001) Structural　basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR　domain. Cell, 104:781-790.　