个人简介

Ph.D., Washington University in St. Louis

研究领域

Natural Products Chemistry, Analytical Chemistry and biochemistry

My research interest is in the area of biologically active phytochemicals. Plants produce a myriad of unusual compounds that are not used for primary metabolism, but are thought to be used for plant survival to various environmental challenges. The biological activities of these phytochemicals, also known as secondary products or natural products, have been harnessed by humans for millennia as medicines. The research conducted in my laboratory examines phytochemicals for novel biological actions. I am specifically interested in phytochemicals with antioxidant activity that may help to prevent cancer and cardiovascular disease. The Phytochemistry Laboratory at Lehman College is a newly renovated facility in Davis Hall, room 119. It is fully equipped with instruments used for the identification and purification of natural products, including a gas chromatograph (HP 6890 with head space sampler), high performance liquid chromatographs (two Waters 2690 with 996 and one Waters 600 controller with 2487 dual wavelength detector), and a LC-MS (Finnigan Mat MS with Waters 2690 and 486 detector). The Phytochemical Laboratory maintains collaborations with students of the CUNY Ph. D. Subprogram in Plant Sciences and Biochemistry, as well as with The New York Botanical Garden and The Richard and Hinda Rosenthal Center for Complementary & Alternative Medicine, Columbia University College of Physicians and Surgeons.

近期论文

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Borquez, J.; Kennelly, E.J.; Simirgiotis, M.J. 2013. Activity guided isolation of isoflavones and hyphenated HPLC-PDA-ESI-ToF-MS metabolome profiling of Azorella madreporica Clos. from northern Chile. Food Res. Int. 52: 288-297. Einbond, L.S.; Mighty, J.; Kasiwazaki, R.; Figueroa, M.; Jalees, F.; Acuna, U.M.; Gendre, O.L.; Foster, D.A.; Kennelly, E.J.* 2013. Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anticancer Agents Med. Chem. PMID: 23848206, in press. Flores, G.; Dastmalchi, K.; Wu, S.B.; Whalen, K.; Dabo, A.J.; Reynertson, K.A.; Foronjy, R.F.; D Armiento, J.M.; Kennelly, E.J.* 2013. Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy. Food Chem. 141: 889-895. Huang, W.; Wu, S.-B.; Wang, Y.-L.; Guo, Z.-Y.; Kennelly, E.J.; Long, C.-L. 2013 Chemical constituents from Striga asiatica and its chemotaxonomic study. Biochem. Syst. Ecol. 48: 100-106. Jiang, B.; Kronenberg, F.; Balick, M.J.; Kennelly, E.J.* 2013. Stability of black cohosh triterpene glycosides and polyphenols: potential clinical relevance. Phytomedicine, 20: 564-569. Kronenberg, F.; Kennelly, E.J. 2013. Phytochemical identity and stability of herbal products: Challenges for clinical (Editorial). Maturitas, in press. Lai, P.K.; Chan, J.Y.; Wu, S.B.; Cheng, L.; Ho, G.K.; Lau, C.P.; Kennelly, E.J.; Leung, P.C.; Fung, K.P.; Lau, C.B. 2013. Anti-inflammatory activities of an active fraction isolated from the root of Astragalus membranaceus in RAW 264.7 Macrophages. Phytother Res. DOI: 10.1002/ptr.5002. Ma, C.; Dastmalchi, K.; Flores, G.; Wu, S.B.; Pedraza-Peñalosa, P.; Long, C.; Kennelly, E.J.* 2013. Antioxidant and metabolite profiling of North American and neotropical blueberries using LC-TOF-MS and multivariate analyses. J. Agric. Food Chem. 61: 3548-3559. Ma, L.J.; Wang, Y.H.; Tang, G.H.; Wang, Y.L.; Ma, C.; Dastmalchi, K.; Kennelly, E.J.; Long, C.L. 2013. New monoterpene lactones from Actaea cimicifuga. Planta Med. 79: 308-311. Petrova, V.I.; Kennelly, E.J. 2013. Blueberries: a "super fruit" complement to cereals. Cereal Foods World 58: 13-17. Wu, S.B.; Long, C.; Kennelly, E.J.* 2013. Phytochemistry and health benefits of jaboticaba, an emerging fruit crop from Brazil. Food Res. Int., 54: 148-159. Wu, S.B.; Meyer, R.S.; Whitaker, B.D.; Litt, A.; Kennelly, E.J.* 2013 A new liquid chromatography-​mass spectrometry-​based strategy to integrate chemistry, morphology, and evolution of eggplant (Solanum) species. J. Chrom. A 1314: 154-172. Wu, S.B.; Wu, J.; Yin, Z.; Zhang, J.; Long, C.; Kennelly, E.J.*; Zheng, S. 2013. Bioactive and marker compounds from two edible dark-colored Myrciaria fruits and the synthesis of jaboticabin. J. Agric. Food Chem. 61:4035-4043. Simirgiotis, M.J.; Schmeda-Hirschmann, G.; Bórquez, J.; Kennelly, E.J. 2013. The Passiflora tripartita (Banana Passion) fruit: A source of bioactive flavonoid C-glycosides isolated by HSCCC and characterized by HPLC–DAD–ESI/MS/MS. Molecules. 18:1672-1692. Acuna, U.M.; Dastmalchi, K.; Basile, M.J.; Kennelly, E.J.* 2012. Quantitative high-performance liquid chromatography photo-diode array (HPLC-PDA) analysis of benzophenones and biflavonoids in eight Garcinia species. J. Food Compos. Anal. 25: 215-220. Bradbury, L.M.T.; Shumskaya, M.; Tzfadia, O.; Wu, S.; Kennelly, E.J.; Wurtzel, E.T. 2012. Lycopene cyclase paralog CruP protects against reactive oxygen species in oxygenic photosynthetic organisms. Proc. Natl. Acad. Sci. U.S.A. 109: 10767-10768. Dastmalchi, K.; Flores, G.; Wu, S.; Ma, C.; Dabo, A.J.; Whalen, K.; Reynertson, K.A.; Foronjy, R.F.; D'Armiento, J.M.; Kennelly, E.J.* 2012. Edible Myrciaria vexator fruits: Bioactive phenolics for potential COPD therapy. Bioorg. Med. Chem. 20: 4549-4555. Flores, G.; Dastmalchi, K.; Dabo, A.J.; Whalen, K.; Pedraza-Penalosa, P.; Foronjy, R.F.; D'Armiento, J.M.; Kennelly, E.J.* 2012. Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii. Food Chem. 131: 119-125. Flores, G.; Dastmalchi, K.; Paulino, S.; Whalen, K.; Dabo, A.J.; Reynertson, K.A.; Foronjy, R.F.; D'Armiento, J.M.; Kennelly, E.J.* 2012. Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment. Food Chem. 1256-1262. Huang, Q.; Bi, J.; Sun, Q.; Yang, F.; Wang, Y.; Tang, G.; Zhao, F.; Wang, H.; Xu, J.; Kennelly, E.J.; Long, C.; Yin, G. 2012. Bioactive isoquinoline alkaloids from Corydalis saxicola. Planta Med. 78: 65-70.