Alessandra, Carriero - Florida Institute of Technology

个人简介

Dr. Alessandra Carriero joined the Department of Biomedical Engineering of Florida Institute of Technology in 2014. Her research examines bone multi-scale mechanics and mechano-adaptation in growth, aging and disease with the aim to predict and prevent bone fractures and deformities, and aid in the development of new treatments for skeletal pathologies. Her interdisciplinary research combines mechanical engineering methods, material science approaches, high-resolution imaging, clinical data and biological analysis to reveal how mechanical forces influence bone growth, maintance and function. An enhanced understanding of the interplay between bone mechanical behaviour, composition, structure and biological function provides new and valuable insights into how healthy bone grows, ages, supports and adapts to loads avoiding deformations and fractures. Investigating how aging and disease change bone properties is of great clinical importance for developing therapies that can repair bone’s mechanical integrity. Dr. Carriero’s research has potential to make significant positive impact on the quality of life of patients while delivering economic benefits. Ph.D., Biomechanics, Imperial College London MSc., Biomedical Engineering, Politecnico di Milano Erasmus Visiting Student, Trinity College Dublin

近期论文

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1. Carriero A., J.L. Bruse, K.J. Oldknow, J.L. Millan, C. Farquharson, S.J. Shefelbine. Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness, Bone, 2014; 69(12): 174-9 2. Carriero A., E.A. Zimmermann, S.J. Shefelbine, R.O. Ritchie. A methodology for the investigation of toughness and crack propagation in mouse bone. J Mech Behav Biomed Mater, 2014; 39: 38-47 3. Carriero A., L. Abela, A. Pitsillides, S.J. Shefelbine. Ex vivo determination of bone tissue strains for an in vivo mouse tibial loading model, J Biomech, 2014; 47(10): 2490-7 4. Carriero A., E.A. Zimmermann, A. Paluszny, S. Tang, H.A. Bale, B. Busse, T. Alliston, G. Kazakia, R.O. Ritchie, S.J. Shefelbine. How tough is brittle bone? Investigating osteogenesis imperfecta mouse bone, J Bone Miner Res, 2014; 29(6): 1392-401 5. Giorgi M., A. Carriero, S.J. Shefelbine, N.C. Nowlan. Mechanobiological simulations of prenatal joint morphogenesis. J Biomech, 2014; 47(5): 989-95 6. Carriero A., M. Doube, M. Vogt, B. Busse, J. Zustin, P. Schneider, R. Müller, S.J. Shefelbine. Altered lacunar and vascular porosity in osteogenesis imperfecta mice bone as revealed by synchrotron tomography contribute to bone fragility. Bone, 2014; 61(4): 116-24 7. Busse B., H.A. Bale, E.A. Zimmermann, B. Panganiban, H.D. Barth, A. Carriero, E. Vettorazzi, M. Hahn, J. Zustin, J.W. Ager, K. Puschel, M. Amling, R.O. Ritchie. Vitamin-D deficiency induces early signs of aging in human bone, increasing the risk of fracture. Sci Transl Med, 2013; 10(5): 193rad88 8. Carriero A., A. Zavatsky, J. Stebbins, T. Theologis, G. Lenaerts, I. Jonkers, S.J. Shefelbine. Influence of altered gait patterns on the hip joint contact forces. Comput Methods Biomech Biomed Engin, 2014; 14(4): 352-359 9. Carriero A., I. Jonkers, S.J. Shefelbine. Modelling proximal femur deformities in children with cerebral palsy. Comput Methods Biomech Biomed Engin, 2011; 14(3): 253-62 10. Carriero A., A. Zavatsky, J. Stebbins, T. Theologis, S.J. Shefelbine. Determination of gait patterns in children with spastic diplegic cerebral palsy using principal components. Gait Posture, 2009; 29(1): 71-5 11. Carriero A., A. Zavatsky, J. Stebbins, T. Theologis, S.J. Shefelbine. Correlation between lower limb bone morphology and gait characteristics in children with spastic diplegic cerebral palsy. J Paediatr Orthop, 2009; 29(1): 73-9