个人简介
Education Experience：
1990-1994 Bachelor of Science Department of Chemistry, Organic Chemistry Lanzhou University
1996-1999 M.S. School of Life Sciences, Biochemistry and Molecula Lanzhou University
2000-2003 Ph. D. Institute for Viral Disease Control, Pathogenic Bi Chinese CDC
2003-2004 Postdoctoral Weill Cornell Medical College, Biochemistry Cornell University
2004-2009 Postdoctoral School of Public Health, Molecular Microbiology an Johns Hopkins University
Professional Experience：
1994-1996 Research fellow Ministry of Health Lanzhou Institute of Biologic Products, First Research Department (Dept. of Bacte
1999-2000 Research fellow Surveying-Designing Institute of Land Reclamation in Gansu Province
2009-2013 Professor Chinese CDC, Institute for Viral Disease Control
2013- Professor Tianjin University, School of Life Sciences
主持、参加科研项目情况：
国家重点研发计划“前沿科技创新”专项：2021.11-2023.11. 经费：342万. 课题负责人
国家自然科学基金面上项目: 发热伴血小板减少综合征病毒调节JunB泛素化介导炎性因子释放的分子机制研究（32170144）. 2022.1-2025.12. 直接经费：58万. 主持.
科技委“科技创新特区”项目：2018.12-2021.3. 经费：265万. 项目负责人
国家重点研发计划“生物安全关键技术”重点专项项目:（2018YFC200901）.2018.7-2021.6. 经费：282万. 课题负责人
国家重点研发计划“纳米科技”重点专项项目:基于稀土发光纳米技术的病原体检测研究（2017YFA0205102）. 2017.7-2022.6. 经费：589万. 课题共同负责人
国家自然科学基金面上项目: SFTS 布尼亚病毒转录调控元件的鉴定及功能研究（31270201）. 2013.1-2016.12. 78万. 主持, 完成.
教育部留学归国人员科研启动基金. 汉坦病毒与宿主细胞相互作用研究. 经费：3万.主持
国家重点基础研究发展计划（973）:重要病毒跨种间感染与传播致病的分子机制研究(2011CB504700).2011-2015. 经费：39万.骨干
奖励与荣誉：
1. 2023 天津大学本科生毕业设计（论文）优秀指导教师
2. 天津大学第二届新工科项目式大赛一等奖
3. 2022 天津市教学成果奖 二等奖
4. 2022 天津大学研究生教学成果一等奖（第二完成人）
5. 2022 天津大学校级优秀硕士学位论文指导教师
6. 2022 天津大学本科生毕业设计（论文）优秀指导教师
7. 2022 天津大学2021年教学成果奖 一等奖 （第二完成人）
8. 2021 天津大学本科生毕业设计（论文）优秀指导教师”
9. 2021 天津大学第十四届研究生“我心目中的十佳好导师”
10. 2021 “天津大学首届教师教学创新大赛”正高组 二等奖
11. 2019 吉林省科技进步奖 一等奖 （第三完成人）
12. 2019 天津大学第十二届研究生“我心目中的好导师”、“最具人气导师”
13. 2019 中国微生物学会病毒学专业委员会/第十三届全国病毒学学术研讨会“大会优秀报告奖”（二等奖）、“大会优秀墙报奖”（指导教师）
14. 2018 中华医学会医学病毒学大会 “大会优秀墙报奖”（两篇，指导教师）
15. 2018 天津市西青区创新创业英才“113”计划创业领军人才
近期论文
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Yuling Zhang#, Leling Xu#, Leling; Zhe Zhang, Xin Su, Zhiyun Wang*, Tao Wang*. Enterovirus D68 infection upregulates SOCS3 expression to inhibit JAK-STAT3 signaling and antagonize the innate interferon response of the host. Virologic Sinica. 2023 Oct;38(5):755-766. doi: 10.1016/j.virs.2023.08.007.
Feifei Li, Sihua Liu, Boyu Luo, Mengqian Huang, Yue Teng*, and Tao Wang*. CRISPR/Cas12a technology combined with RPA for rapid and portable MPXV detection. Microbiology Spectrum. 2023 May 8:e0423322. doi: 10.1128/spectrum. 04233-22.
Sihua Liu, Yazhi Su, Zhuozhuang Lu, Xiao-Hui Zou, Leling Xu, Yue Teng*, Zhiyun Wang*, and Tao Wang*. The SFTSV nonstructural proteins induce autophagy to promote viral replication via interaction with Vimentin. J Virol. 2023 Apr 27;97(4):e0030223. doi: 10.1128/jvi.00302-23.
Jun Kang#, Mengqian Huang#, Jinyu Li1#, Keke Zhang, Cheng Zhu, Sihua Liu, Zhenwei Zhou, Tao Wang*, Zhiyun Wang*. Enterovirus D68 VP3 targets the interferon regulatory factor 7 to inhibit1 type I interferon response. Microbiology Spectrum. 2023 May 1; e0413822. doi: 10.1128/spectrum.04138-22
Hongyun Liu#, Sihua Liu#, Zixiang Liu, Xiaoning Gao, Leling Xu, Mengqian Huang, Yazhi Su, Zhiyun Wang*, Tao Wang*. Dabie bandavirus Non-structural Protein Interacts with Actin to Induce F-actin Rearrangement and Inhibit Viral Adsorption and Entry. J Virol. 2022 Jul 27; 96(14): e0078822. doi: 10.1128/jvi.00788-22.
Zhiyun Wang#*, Qiuzi Zhao#, Mengqian Huang, Yuqin Duan, Feifei Li, Tao Wang*. Dual detection of hemagglutinin proteins of H5N1 and H1N1 influenza viruses based on FRET combined with DNase I. Frontiers in Microbiology. 2022 Jun 30;13:934475. doi: 10.3389/fmicb. 2022.934475.
Peiyuan Liu#，Yanfeng Zhang#，Zibin Li，Jianwen Huang*，TaoWang*，ChengChen*. Structural insights revealed by crystal structure of B38-CAP, an isoenzyme of carboxypeptidase ACE2, the receptor of SARS-CoV-2. Biochemical and Biophysical Research Communications. 28 May 2022; 606: 17-22. Doi: 10.1016/j.bbrc.2022.03.077
Mengqian Huang#, Sihua Liu1#, Yanan Xu, Aqian Li, Wei Wu, Mifang Liang, Guoyu Niu, Zhiyun Wang* and Tao Wang*. CRISPR/Cas12a Technology Combined with RPA for Rapid and Portable SFTSV Detection. Frontiers in Microbiology. 25 January 2022; 13: 754995. DOI: 10.3389/fmicb.2022.754995.
Jinyu Li#, Shan Yang#, Sihua Liu#, Yulu Chen, Hongyun Liu, Yazhi Su, Ruicun Liu, Yujun Cui, Yajun Song*, Yue Teng*, Tao Wang*. Transcriptomic profiling reveals a role for TREM-1 activation in enterovirus D68 infection-induced proinflammatory responses. Frontiers in Immunology. 23 November 2021; 12: 749618. DOI: 10.3389/fimmu.2021.749618.
Jinyu Li#, Ruicun Liu#, Yulu Chena#, Shuxia Liu, Cheng Chen, Tuoyu Liu, Shan Yang, Yingtan Zhuang, Ruifu Yang, Yujun Cui, Yajun Song*, Tao Wang*, Yue Teng*. Computer-aided rational engineering of signal sensitivity of quorum sensing protein LuxR in a whole-cell biosensor. Frontiers in Molecular Bioscience. 2021 August 13. doi.org/10.3389/fmolb.2021.729350.
Xianhuang Li#, Mingming Guo#, Bei Hou#, Bin Zheng*, Zhiyun Wang, Mengqian Huang, Yanan Xu, Jin Chang, and Tao Wang *. CRISPR/Cas9 nanoeditor of double knockout large fragments of E6 and E7 oncogenes for reversing drugs resistance in cervical cancer. Journal of Nanobiotechnology. 2021 Aug 5;19 (1): 231. doi: 10.1186/s12951-021-00970-w.
Qiuzi Zhao, Ping Du, Xiaoyong Wang, Mengqian Huang, Ling-Dong Sun, Tao Wang*, Zhiyun Wang*. An upconversion fluorescent resonant energy transfer aptasensor for H5N1 influenza virus detection. ACS Omega. 2021 Jun 4; 6(23): 15236-15245.
Sihua Liu, Mengqian Huang, Yanan Xu, Jun Kang, Sheng Ye, Si Liu, Zhiyun Wang, Hongyun Liu, Jibin Yu, Kongxin Hu*, Tao Wang*. CRISPR/Cas12a Technology Combined with RT-ERA for Rapid2 and Portable SARS-CoV-2 Detection. Virologica Sinica. 2021 Jun 2;1-5.
Yi Qin#, Weipan Peng#, Xiaoqun Gong*, Dianming Zhou, Wenna Li, Minghui Chen, Guowei Lian, Jin Chang*, and Tao Wang*. MicroRNA--Responsive DNA-Programmed Nanomedicine with Controllability of Cascaded Events for Cancer Therapy Enhancement. ACS Macro Letters. 2021 May 10. 2021, 10, 6, 654-661.
Yanan Xu#, Bin Zheng#*, Mengqian Huang, Xianhuang Li, Zhiyun Wang, Jin Chang, Tao Wang*. Sendai virus acts as a nano-booster to excite dendritic cells for enhancing the efficacy of CD47-directed immune checkpoint inhibitors against breast carcinoma. Mater Chem Front. 2021, 5, 223-237. doi: 10.1039/D0QM00393J. (Inside Front Cover. 2020 Materials Chemistry Frontiers HOT articles).
Bin Zheng#, Yanan Xu#, Mengqian Huang, Xianhuang Li, Tao Wang*, and Dong Ming*. Bio-Inorganic Hybrid Nongenetically Modified Viruses as an Immune Agonist for Systemic Elimination of Cancer Cells. ACS Appl. Mater. Interface. 2020 Nov 18; 2020,12,48: 53691–53704. doi: 10.1021/acsami.0c16978.
Jun Kang#, Zheng Pang#, Zhenwei Zhou, Xianhuang Li, Sihua Liu, Jinyan Cheng, Peiyuan Liu, Wenjie Tan, Zhiyun Wang*, Tao Wang*. Enterovirus D68 Protease 2Apro Targets TRAF3 To Subvert Host Innate Immune Responses. J Virol. 2020 Nov 4; 95 (3), Online ahead of print. doi: 10.1128/JVI.01856-20.
Jinyan Cheng, Shuai Gao, Cheng Zhu, Sihua Liu, Jinyu Li, Jun Kang, Zhiyun Wang*, Tao Wang*. Typical SG proteins interact with the 3'-UTR of EV-D68 to inhibit viral replication. J Virol. 2020 Mar 17;94(7): e02041-19. doi: 10.1128/JVI.02041-19.
Sihua Liu, Hongyun Liu, Jun Kang, Leling Xu, Keke Zhang, Xueping Li, Wen Hou， Zhiyun Wang*, Tao Wang*. The SFTSV NSs protein interacts with CDK1 to induce G2 cell cycle arrest and positively regulate viral replication. J Virol. 2020 Feb 28;94(6): e01575-19. doi: 10.1128/JVI.01575-19.
Sihua Liu, Hongyun Liu, KeKe Zhang, Xueping Li, Yuqin Duan, Zhiyun Wang*, Tao Wang*. Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus. Virologica Sinica. 2019 Oct;34(5):572-582. Epub 2019 Oct 21.
Minglei Pan, Shuai Gao, Zhenwei Zhou, Keke Zhang, Sihua Liu, Zhiyun Wang*, Tao Wang*. A reverse genetics system for Enterovirus D68 using human RNA polymerase I. Virus Genes. 2018 Aug;54(4):484-492. Epub 2018 May 17.
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