文富强 - 四川大学 - 生物治疗国家重点实验室

个人简介

呼吸病学国家重点学科 - 四川大学华西医院呼吸内科主任、生物治疗国家重点实验室呼吸病学研究室主任。美国胸科学会（ ATS ）临床委员会委员、美国胸科医师协会（ ACCP ）中国西部地区负责人，中华医学会呼吸病学分会委员。擅长呼吸疾病特别是慢性阻塞性肺疾病、肺心病，支气管哮喘、肺纤维化及急性呼吸窘迫综合征发病机制研究和临床诊治。负责和参加了国家杰出青年科学基金、国家自然科学基金、美国 NIH 、日本政府文部科学省、美国 CMB 等慢性阻塞性肺疾病、哮喘及肺纤维化发病机制及治疗研究多项课题。在 SCI 收录的国际呼吸疾病著名杂志发表论著 90 余篇。

研究领域

呼吸系统重大疾病及肺结核发病机理及生物治疗呼吸系统疾病分子细胞生物学、表观遗传学研究高原缺氧与血管生理与病理生理学慢性气道炎症性疾病分子机制与生物治疗研究肺损伤、修复及纤维化机制与生物治疗

近期论文

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Chen L, Sun BB, Wang T, Wang X, Li JQ, Wang HX, Zhang SF, Liu DS, Liu L, Xu D, Ou XM, Chen YJ, Yang T, Zhou H, and Wen FQ *. Cigarette smoke enhances b -defensin 2 expression in rat airways via NF-kB activation . Eur. Respir. J. 2010; 36: 638-645. Wang T, Liu Y, Chen L, Wang X, Hu XR, Feng YL, Liu DS, Xu D, Duan YP, Lin J, Ou XM, Wen FQ *. Effect of sildenafil on acrolein- induced airway inflammation and mucus production in rats. Eur. Respir. J. , 2009; 33: 1122-1132. Huang XY, Yang NP, Ou XM, Li D, Wang ZM, Xie QB, Chen YT, Lin H, Yin G, Wen FQ *. Sequential Activation of Protein Kinase C Delta and Jnk Is Required for Interferon- Alpha-Induced Expression of Ifit4. Cell Signal. 2008; 20: 112-119. Wang T, Han SX, Zhang SF, Ning YY, Chen L, Chen YJ, He GM, Xu D, An J, Yang T, Zhang XH, Wen FQ *. Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters. Respir. Res. 2010; 11:36. Chen L, Wang T, Wang X, Sun BB, Li JQ, Liu DS, Zhang SF, Liu L, Xu D, Chen YJ, Wen FQ *. Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats. Respir. Res. 2009; 10:55 Han SX, He GM, Wang T, Chen L, Ning YY, Luo F, An J, Yang T, Dong JJ, Liao ZL, Xu D, Wen FQ *. Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: possible involvement of angiotensin-converting enzyme-2. Toxicol. Appl. Pharmacol. 2010; 245: 100-7. Liu DS, Liu WJ, Chen L, Ou XM, Wang T, Feng YL, Zhang SF, Xu D, Chen YJ, Wen FQ * . Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates acrolein-induced airway mucus hypersecretion in rats. Toxicology 2009; 260: 112-119. Hou Y, An J, Hu XR, Sun BB, Lin J, Xu D, Wang T, Wen FQ *. Ghrelin inhibits interleukin-8 production induced by hydrogen peroxide in A549 cells via NF-kappaB pathway. Int. Immunopharmacol . 2009; 9: 120-126 Ou XM, Wen FQ *, Uhal BD, Feng YL, Huang XY, Wang T, Wang K, Liu DS, Wang X, Cheng L. Simvastatin attenuates experimental small airway remodelling in rats. Respirology 2009; 14: 734-745. Liu Q, Chen X, Hu C, Zhang R, Yue J, Wu G, Li X, Wu Y, Wen FQ *. Serum protein profiling of smear-positive and smear-negative pulmonary tuberculosis using SELDI-TOF mass spectrometry. Lung . 2010; 188: 15-23. Wang K, Wen FQ *, Feng YL, Ou XM, Xu D, Yang J, Deng ZP. Increased expression of human calcium-activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway. Cell Biol. Int. 2007; 31: 1388-1395. Wen FQ , Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI. IFN-gamma inhibits TGF-beta production in human airway epithelial cells by targeting Smads. Am. J. Respir. Cell. Mol. Biol . 2004 ; 30: 816-82. Wen FQ , Manda W, Liu X.D, Terasaki Y, Kobayashi T, Abe S, Fang Q, Ertl R, Manouilova L, Rennard SI. Th2 cytokine- and TGF-beta1-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by interferon-gamma and corticosteroids. J. Allergy. Clin. Immunol. 2003; 111: 1307-1318