个人简介
医学博士，浙江大学医学院附属二院呼吸科副主任，浙江大学呼吸疾病研究所秘书，从事临床工作18年，积累了较丰富的临床经验。目前主持卫生部项目1项，主参国家自然科学基金、省、部级科研课题多项。主要从事慢性阻塞性肺疾病（COPD）和支气管哮喘发病机制及防治的研究，首次在国内成功分离培养出原代人体气道上皮细胞，对气道上皮细胞信号转导通路的研究具有较深造诣。在Allergy、BBRC、APS、CMJ、中华结核和呼吸杂志及中国病理生理杂志等国内外期刊发表学术论文10余篇，其中SCI收录论文9篇。 对呼吸系统常见病和多发病的诊断和治疗具有较丰富的临床经验，特别擅长慢性咳嗽、哮喘、COPD、肺部感染的诊治。
近期论文
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1. Yan F, Li W（co-author），Zhang S，et al. P. aeruginosa Lipopolysaccharide-induced MUC5AC Expression via TLR4-PKC-Duox1 Cascades. Am J Respir Cell Mol Biol. Submitted.
2. Fugui Yan, Li W,（co-author）, Hirofumi Jono, et al. Reactive oxygen species regulate Pseudomonas aeruginosa Lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-signaling pathways in human airway epithelial cells. BBRC. 2008, 366(2):513-9.
3. Shen H, Huang H, Wang J, Ye S, Li W, Wang K, Zhang G, Wang P. Neonatal vaccination with Bacillus Calmette-Guerin elicits long-term protection in mouse allergic responses. Allergy. 2008, 63: 555-563.
4. Ben SQ, Li XB, Xu F, Xu WH, Li W, Wu ZQ, Huang HQ, Shi GZ, Shen HH. Treatment with anti-CCR3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34+ progenitor cells in an allergic mouse model. Allergy. 2008, 63:1164-1176
5. Zhang GS, Xu ZH, Cui W, Zhou F, Xia Y, Li W, Li LB, Shen HH. A case with lethal endobronchial lymphoma presenting with respiratory failure requiring intubation and mechanical ventilation. Chin Med J (Engl). 2008, 121(3) :280-282.
6. Li W, Shen HH. Effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice. Chin Med J (Engl). 2007,120(1) :5-11.
7. Li Wen, Shen HH. Effect of cigarette smoke extract on lipopolysaccha-ride-activated mitogen-activated protein kinase signal transduction pathway in cultured cells. Chin Med J (Engl). 2007,120(12):1075-81.
8. Wang K, Shen HH, Li W, Huang HQ. Human C-C chemokine receptor 3 monoclonal antibody inhibits pulmonary inflammation in allergic mice. Acta Pharmacol Sin. 2007，28(11):1791-6.
9. Shen HH, Yoshida H, Yan FG, Li W, Xu F, Huang HQ, Jono H, Li JD. Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae. BBRC 2007, 365(4):795-800.
10. Li W, Xu YJ, Zhang Z. Influences of interleukin 4 and interleukin 6 on the amiloride-sensitive Na+ channel current in human bronchial epithelium cells of COPD patients. Chinese Journal of Pathophysiology. 2006, 22(2) :318-321.
11. Li W, Xu YJ, Zhang Z. Influence of lipopolysaccharide on the expression of Toll-like receptor 4 in human bronchial epithelium cell in patients with chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi. 2006,27(7) : 448-451.
12. Li W, Xu YJ, Zhang Z. Zhang Zheng-xiang. Activity of matrix metalloproteinase in airway epithelial cells of COPD patients. J Huazhong Univ Sci Technolog Med Sci. 2005, 25(2): 151-154.
13. Li W, Xu YJ, Zhang Z. Detection of the mRNA level of the subunits of amiloride-sensitive Na+ channel in human bronchial epithelium cells from patients with chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi. 2004, 27(8):533-536.
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