Wylie, Ryan - McMaster University - Department of Chemistry & Chemical Biology

个人简介

Ryan has a BSc in Biochemisty from Concordia University, a PhD supervised by Molly Shoichet at University of Toronto and post-doctoral experiences in the Kohane and Langer labs at MIT

研究领域

Our expertise lies at the interface of biomaterials and photonics, where we can tailor the properties of materials with light. We are particularly interested in designing highly ordered responsive materials to better understand cell-matrix interactions for applications in 3D cell culture, tissue engineering, and cancer metastasis. The ability to accurately reproduce the natural environment that cells and tissue encounter within an in vitro model will allow for greater fundamental understanding of cell biology. To accomplish these goals, we are designing 3D scaffolds tunable in space and time to study and guide cell growth. With these technologies we hope to control stem cell differentiation, fabricate functional tissues for implantation and build biological models. We are also interested in expanding this technologies to control cell-matrix interactions in vivo for therapeutic applications.

近期论文

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Lim DK, Barhoumi A, Wylie RG, Langer RS, Kohane DS. Enhanced Photothermal Effect of Plasmonic Nanoparticles Coated with Reduced Graphene Oxide. Nano Letters 13, 4075-4079.doi: 10.1021/nl4014315 Wylie RG, Shoichet MS. Three-dimensional spatial patterning of proteins in hydrogels. Biomacromolecules 12, 3789-3796 (2011). doi:10.1021/bm201037j Wylie RG, Ashan S, Maxwell KL, Morshead CM, Shoichet MS. Three-dimensional, spatially- controlled simultaneous patterning of multiple growth factors in hydrogels. Nature Materials 10, 799-806 (2011). doi:10.1038/nmat3101 (Cover Artwork; featured in News and Views of Nature Materials Vol. 10 No. 10, and McEwen Monthly Sept 2011) Leipzig ND, Wylie RG, Kim H, Shoichet MS. Differentiation of neural stem cells in three- dimensional growth factor-immobilized chitosan hydrogel scaffolds. Biomaterials 32, 57-64 (2011) doi:10.1016/j.biomaterials.2010.09.031 Wang Y, Cooke MJ, Lapitsky Y, Wylie RG, Sahewsky N, Corbett D, Morshead CM, Shoichet MS. Transport of epidermal growth factor in the stroke-injured brain. Journal of Controlled Release 149, 225-235 (2011). doi:10.1016/j.jconrel.2010.10.022 Aizawa Y, Wylie RG, Shoichet MS. Endothelial Cell Guidance in 3D Patterned Scaffolds. Advanced Materials 22, 4831-4835 (2010). doi:10.1002/adma.201001855 Rahman N, Purpura, KA, Wylie RG, Zandstra PW, Shoichet MS. The use of vascular endothelial growth factor functionalized agarose to guide pluripotent stem cell aggregates toward blood progenitor cells. Biomaterials 31, 8262-8270 (2010). doi:10.1016/j.biomaterials.2010.07.040 Taerum T, Lukoyanova O, Wylie RG, Perepichka, DF. Synthesis, Polymerization, and Unusual Properties of New Star-Shaped Thiophene Oligomers. Organic Letters 11, 3230-3233 (2009). doi:10.1021/ol901127q Wylie RG, Shoichet, MS. Two-photon micropatterning of amines within an agarose hydrogel. Journal of Materials Chemistry 18, 2716-2721 (2008). doi:10.1039/B718431J McAlvin B, Wylie R, Mizrahi B, Kohane D.S.. U.S. Provisional Patent Application, 2013 Systems and Methods for Extracorporeal Blood Modification (Filed) Wosnick J, Wylie R, Shoichet M.S. U.S. Provisional Patent Application, 2008 Three- Dimensional Patterned Hydrogels Patent Pub. No. 2008/028630 Lavesque, S.; Wylie, R.; Aizawa, Y.; Shoichet, M.S. 2008 Peptide Modification of Polysaccharide Scaffolds for Targeted Cell Signaling Handbook of Natural-based Polymersfor Biomedical Applications, Ch. 9, pp. 260-87, edited by R.L. Reis, Woodhead Publishing Ltd, UK.