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Peng He, Juanjuan Feng, Xinting Xia, Yue Sun, Jia He, Tian Guan, Yangrui Peng, Xueli Zhang, Mingyao Liu, Xiufeng Pang*, and Yihua Chen*. Discovery of a Potent and Oral Complex I OXPHOS Inhibitor that Abrogates Tumor Growth and Circumvents MEKi Resistance. J. Med. Chem. 2023, 66, 6047-6069.
Jia He, Luzhen Wang, DaZhao Mi, Tian Guan, Wenjing Liu, Peng He, Haijun Gu, Yuzhan Li, Yangrui Peng, Ai-Qun Jia, Ceshi Chen*, and Yihua Chen*. Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med. Chem. 2023, 66, 7421-7437.
Haijun Gu, Ting Zhang, Tian Guan, Min Wu, Shen Li, Yunqi Li, Mengmeng Guo, Lin Zhang, Yangrui Peng, Dazhao Mi, Mingyao Liu, Zhengfang Yi,* and Yihua Chen*. Discovery of a Highly Potent and Selective MYOF Inhibitor with Improved Water Solubility for the Treatment of Gastric Cancer. J. Med. Chem. 2023, doi: 10.1021/acs.jmedchem.3c01639.
Dazhao Mi, Yuzhan Li, Haijun Gu, Yan Li, and Yihua Chen*. Current Advances of Small Molecule E3 Ligands for Proteolysis-Targeting Chimeras Design. Eur. J. Med. Chem. 2023, 256, 115444. (Cover Story)
Luzheng Wang, Dazhao Mi, Jinhui Hu, Wenjing Liu, Yi Zhang, Chunyan Wang*, Yihua Chen*, Ceshi Chen*. A novel methuosis inducer DZ-514 possesses antitumor activity via activation of ROS-MKK4-p38 axis in triple negative breast cancer. Cancer Lett.2023,555, 216049.
Huang Chen, Wenbo Zhou, Aiwu Bian, Qiansen Zhang, Ying Miao, Xuan Yin, Jiangnan Ye, Shifen Xu, Chaowen Ti, Zhenliang Sun, Jianghua Zheng, Yihua Chen*, Mingyao Liu*, Zhengfang Yi*. Selectively targeting STAT3 using a small molecule inhibitor is a potential therapeutic strategy for pancreatic cancer. Clin. Cancer Res. 2023, 29, 815-830.
Yuzhu Zhang, Jing Chen, Dazhao Mi, Jun Ling, Huachao Li, Peng He, Ning Liu3, Qianjun Chen*, Yihua Chen*, Luqi Huang*. Discovery of YH677 as a cancer stemness inhibitor for suppressing triple-negative breast cancer growth and metastasis by regulating the TGFβ signaling pathway. Cancer Lett., 2023, 560, 216142.
Dazhao Mi, Yuzhan Li and Yihua Chen*. Small-Molecule Modulators Targeting SHP2 for Cancer Therapy. Anti-Cancer Agents Med. Chem.2023, 23, 498-504.
Weikai Guo, Manjie Wang, Zhengfan Yang, Danyang Liu, Borui Ma, Yanqun Zhao, Yihua Chen*, and Yanzhong Hu*. Recent advances in small molecule and peptide inhibitors of glucose-regulated protein 78 for cancer therapy. Eur. J. Med. Chem. 2023, 261, 115792.
Lin Zhang, Min Wu, Weikai Guo, Shuangshuang Zhu, Shen Li, Shiyi Lv, Yan Li, Layang Liu, Yajing Xing, Huang Chen, Mingyao Liu, Shihong Peng*, Yihua Chen*, Zhengfang Yi*. A small molecule BCL6 inhibitor as chemosensitizers in acute myeloid leukemia. Biomedicine & Pharmacotherapy, 2023, 166, 115358.
Yali Wang, Wenbo Zhou, Jianfeng Chen, Jinghong Chen, Peng Deng, Huang Chen, Yichen Sun, Zhaoliang Yu, Diwen Pang, Lizhen Liu, Peili Wang, Jing Han Hong, Bin Tean Teh, Huiqiang Huang, Wenyu Li, Zhengfang Yi, Soon Thye Lim, Yihua Chen, Choon Kiat Ong, Mingyao Liu*, and Jing Tan*. Preclinical characterization of WB737, a potent and selective STAT3 inhibitor, in natural killer/T-cell lymphoma. MedComm,2023, 4, e284. (Cover Story)
Haixiang Pei, Weikai Guo, Yangrui Peng, Hai Xiong, Yihua Chen*. Targeting Key Proteins involved in Transcriptional Regulation for Cancer Therapy: Current Strategies and Future Prospective. Med. Res. Rev.2022,42, 1607-1660.
Wangrui Jin, Tao Zhang, Wenbo Zhou, Peng He, Yue Sun, Shijia Hu, Huang Chen, Xinglong Ma, Yangrui Peng, Zhengfang Yi, Mingyao Liu, Yihua Chen*. Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis. J. Med. Chem.2022, 65, 6710-6728.
Peng He, Ying Miao, Yue Sun, Aiwu Bian, Wangrui Jin, Huang Chen, Jiangnan Ye, Jia He, Yangrui Peng, Haijun Gu, Mingyao Liu, Zhengfang Yi*, and Yihua Chen*. Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr705/Ser727 Inhibitory Activity for Gastric Cancer Treatment. J. Med. Chem.2022, 65, 12650-12674.
Peng He, Aiwu Bian, Ying Miao, Wangrui Jin, Huang Chen, Jia He, Liting Li, Yue Sun, Jiangnan Ye, Mingyao Liu, Zhengfang Yi*, Wenbo Zhou*, and Yihua Chen*. Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer treatment. J. Med. Chem.2022, 65, 15487-15511.
Haijun Gu, Jia He, Yuzhan Li, Dazhao Mi, Tian Guan, Weikai Guo, Bo Liu* and Yihua Chen*. B?cell lymphoma 6 inhibitors: current advances and prospects of drug development for diffuse large B-cell lymphomas. J. Med. Chem.2022, 65, 15559-15583.
Yuzhu Zhang, Dazhao Mi and Yihua Chen*.An instructive attempt on developing aptamer-constructed PROTAC for potential breast cancer treatment. Molecular Therapy - Nucleic Acids. 2022, 30, 351-352.
Haijun Gu, Ting Zhang, Yunqi Li, Yuan He, Tian Guan, Weiqiong Kan, Peng He, Zhengfang Yi, Yihua Chen*. Discovery of 1,5-diaryl-1,2,4-triazole derivatives as MYOF inhibitors and its antitumor effects in pancreatic cancer. Future Med. Chem.2022, 14,1425-1440.
Shijia Hu, Yunqi Li, Weiqiong Kan, Tingting Ding, Haijun Gu, Ting Zhang Zhengfang Yi, Yihua Chen*.Novel ortho-diphenyl-five-member N-hetero- aromatics compounds as potent anti-cancer cell agents. Med. Chem. Res., 2022, 31, 936-948.
Haixiang Pei, Yihua Chen*. The promising combination therapy strategy for overcoming resistance to histone deacetylase inhibitors in diffuse large B-cell lymphoma. Clin. Trans. Discovery, 2022, 2, e56.
Yajing Xing, Weikai Guo, Min Wu, Jiuqing Xie, Dongxia Huang, Pan Hu, Miaoran Zhou, Lin Zhang, Qiansen Zhang, Peili Wang, Xin Wang, Guixue Wang, Huangan Wu, Cili Zhou, Yihua Chen, Mingyao Liu, Zhengfang Yi, Zhenliang Sun. An orally available small molecule BCL6 inhibitor effectively suppresses diffuse large B cell lymphoma cells growth in vitro and in vivo. Cancer Lett.2022, 529, 100-111.
Yuan He, Weiqiong Kan, Yunqi Li, Yun Hao, Anling Huang, Haijun Gu, Minna Wang, Qingqing Wang, Jinlian Chen, Zhenliang Sun, Mingyao Liu*, Yihua Chen*, Zhengfang Yi*. A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression. Clin. Trans. Med.2021, 11, e289.
Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu, Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun, Zhengfang Yi,* Mingyao Liu* andYihua Chen*. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Cancer Progression. Adv. Sci. 2020, 7, 1903483.
Liang Li, Dazhao Mi, Haixiang Pei, Qiuhui Duan, Xinyue Wang, Wenbo Zhou, Jianping Jin, Dali Li, Mingyao Liu* and Yihua Chen*. In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15. Signal Trans. Targeted Therapy.2020, 5, 129.
Weikai Guo, Yajing Xing, Qiansen Zhang, Jiuqing Xie, Dongxia Huang, Haijun Gu, Peng He, Miaoran Zhou, Shifen Xu, Xiufeng Pang, Mingyao Liu,* Zhengfang Yi,* Yihua Chen*. Synthesis and Biological Evaluation of B?Cell Lymphoma 6 Inhibitors of N-phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth. J. Med. Chem. 2020, 63, 676-695.
Kewen Hu, Kun Li, Jing Lv, Jie Feng, Jing Chen, Haigang Wu, Feixiong Cheng, Wenhao Jiang, Jieqiong Wang, Haixiang Pei, Paul J. Chiao, Zhenyu Cai, Yihua Chen*, Mingyao Liu*, Xiufeng Pang*. Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma. J. Clin. Invest. 2020, 130, 1752-1766.
Tingting Fan, Weikai Guo, Ting Shao, Wenbo Zhou, Pan Hu, Mingyao Liu, Yihua Chen* and Zhengfang Yi*. Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane. Eur. J. Med. Chem. 2020, 190, 112141.
Feifei Yang, Na Zhao, Lina Han, Yang Yang, Di Ge*, Hua Zhang*, Yihua Chen* Synthesis and Biological Evaluation of Novel Thiophene-based N-bis-substituted Aromatic Amide Hydroxamic Acid Derivatives as Histone Deacetylase Inhibitors with Antitumor Activities. Future Med. Chem. 2020, 12, 655-672.
Haijun Gu, Yangrui Peng and Yihua Chen*, An Emerging Therapeutic Approach by Targeting Myoferlin (MYOF) for Malignant Tumors. Curr. Topics Med. Chem.2020, 20, 1509-1515.
Ting Shao, Wenshu Tang, Yunqi Li, Dan Gao, Kaiyang Lv, Peng He, Yajuan Song, Song Gao, Mingyao Liu*, Yihua Chen*, Zhengfang Yi*. Research on Function and Mechanisms of a Novel Small Molecule WG449E for Hypertrophic Scar. J. Eur. Acad. Dermatol., 2020, 34, 608-618.
Yunqi Li, Yuan He, Ting Shao, Haixiang Pei, Weikai Guo, Dazhao Mi, Isabelle Krimm, Yuanjin Zhang, Peili Wang, Xin Wang, Mingyao Liu,* Zhengfang Yi,* Yihua Chen*. Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin. J. Med. Chem. 2019, 62, 4949-4966.
Liqiang Su, Jiahui Li, Zhen Zhou, Dongxia Huang, Yuanjin Zhang, Haixiang Pei, Weikai Guo, Haigang Wu, Xin Wang, Mingyao Liu, Cai-Guang Yang*, Yihua Chen*. Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. Eur. J. Med. Chem. 2019, 162, 203-211.
Haixiang Pei, Juliang Qin, Fengmian Wang, Binghe Tan, Zeda Zhao, Yangrui Peng, Fangfei Yu, Ennian Li, Mingyao Liu, Rong Zhang, Bo Liu*, Bing Du*, Yihua Chen*.Discovery of Potent Ureido Tetrahydrocarbazole Derivatives for Cancer Treatments through targeting Tumor-associated Macrophages. Eur. J. Med. Chem. 2019,183, 111741.
Haixiang Pei, Yangrui Peng, Qiuhua Zhao*, Yihua Chen*. Small Molecule PROTACs: An Emerging Technology for Targeted Therapy in Drug Discovery. RSC Advances, 2019, 9, 16967-16976.
Peng He, Wenbo Zhou, Mingyao Liu, and Yihua Chen*. Recent Advances of Small Molecular Regulators Targeting G Protein-Coupled Receptors Family for Oncology Immunotherapy. Curr. Topics Med. Chem.2019, 19, 1464-1483.
Feifei Yang, Na Zhao, Di Ge, Yihua Chen*, Next-Generation of Selective Histone Deacetylase Inhibitors. RSC Advances, 2019, 19571-19583.
Di Ge, Lina Han, Feifei Yang*, Na Zhao, Yang Yang, Hua Zhang* and Yihua Chen* Development of Hydroxamate-Based Histone Deacetylase Inhibitors of Bis-substituted Aromatic Amides with Antitumor Activities. MedChemComm, 2019, 10, 1828-1837.
Yang-jiong Xiao, Yang Yu, Dan Gao, Wangrui Jin, Pengcheng Jiang, Yuhong Li, Chao Wang, Yuning Song, Peng Zhan, Fei Gu, Cancan Zhang, Bin Wang, Yihua Chen*, Bing Du*, Rong Zhang*. Inhibition of CDC25B with WG-391D impedes the tumorigenesis of ovarian cancer. Frontiers in Oncology. 2019, 9, 236.
Tao Zhang, Jingjie Li, Yuan He, Feifei Yang, Yun Hao, Wangrui Jin, Jing Wu, Zhenliang Sun, Yunqi Li, Yihua Chen*, Zhengfang Yi* and Mingyao Liu*. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat. Commun., 2018, 9, 3726.
Tao Zhang*, Jingjie Li, Xiaojun Ma, Yang Yang, Yuan He, Wangrui Jin, Wei Sun, Lei Wang, Yingqi Hua, Zhengfang Yi, Mingyao Liu, Yihua Chen*, Zhengdong Cai*.Inhibition of HDACs-EphA2 signaling Axis with WW437 demonstrates promising preclinical antitumor activity in breast cancer. EBioMedicine, 2018, 31, 276-286.
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