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成果及论文

代表性论文

1. Li M*, Wang Z*, Tao J*, Jiang H, Yang H, Guo D, Zhao H, He X, Luo S, Jiang X, Yuan L, Xiao L, He H, Yu R, Fang J, Liang T, Mao Z, Xu D#, Lu Z#. Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression. Nature chemical biology 2024 Mar 27.  Epub ahead of print. (*co-first author, #co-corresponding author)

2. Wang Z*, Yan M*, Ye L*, Zhou Q*, Duan Y, Jiang H, Wang L, Ouyang Y, Zhang H, Shen Y, Ji G, Chen X, Tian Q, Xiao L, Wu Q, Meng Y, Liu G, Ma L, Lei B#, Lu Z# and Xu D#. VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation. The EMBO Journal. (2024) . (*co-first author, #co-corresponding author)

3. Wang Z, Ma L, Meng Y, Fang J#Xu D#, Lu Z#. The interplay of the circadian clock and metabolic tumorigenesis. Trends in Cell Biology. (2023) Dec; online ahead of print. (#co-corresponding author)

4. Wu K*, Yan M*, Liu T*, Wang Z*, Duan Y, Xia Y, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Wu Q, Xiao L, Yang X, Shen H, Wen T, Zhang J, Yi J, Deng Y, Qian X, Ma L, Fang J, Zhou Q#, Lu Zand Xu D#. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nature Cell Biology. (2023) May;25(5):714-725. (*co-first author,#co-corresponding author)

5. Liu T*, Wang Z*, Ye L*, Duan Y*, Jiang H, He H, Xiao L, Wu Q, Xia Y, Yang M, Wu K, Yan M, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Shao F, Qian X, Yu R, Zhang Z, Lu Zand Xu D#. Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth. Nature Cell Biology. (2023) Feb;25(2):273-284. (*co-first author,#co-corresponding author)

6. Wang Z*, Li M*, Jiang H, Luo S, Shao F, Xia Y, Yang M, Ren X, Liu T, Yan M, Qian X, He H, Guo D, Duan Y, Wu K, Wang L, Ji G, Shen Y, Li L, Zheng P, Dong B, Fang J, Zheng M, Liang T, Li H, Yu R, Xu Dand Lu Z#. Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth. Nature Cell Biology. (2022) Nov;24(11):1655-1665. (*co-first author,#co-corresponding author)

7. Xu D*, Shao F*, Bian X*, Meng Y, Liang T and Lu Z. The Evolving Landscape of  Noncanonical Functions of  Metabolic Enzymes in Cancer and Other Pathologies. Cell Metabolism. (2021) Jan 5;33(1):33-50.(*co-first author)

8. Xu D*#, Wang Z*, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu J, Wang H, Xing D, Liang T, Hung MC# and Lu Z#. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. (2020) Apr;580(7804):530-535. (*co-first author,#co-corresponding author)

9. Xu D, Li X, Shao F, Lv G, Lv H, Lee JH, Qian X, Wang Z, Xia Y, Du L, Zheng Y, Wang H#, Lyu J# and Lu Z#. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Science Advances. (2019) Apr 24;5(4):eaav4570. (#co-corresponding author)

10. Xu D, Wang Z and Chen Y. Two-layer regulation of PAQR3 on ATG14-linked class III Ptdlns3K activation upon glucose starvation. Autophagy. (2016) Jun 2;12(6):1047-8.

11. Xu D, Wang Z, Wang C, Zhang D, Wan H, Zhao Z, Gu J, Zhang Y, Li Z, Man K, Pan Y, Wang Z, Ke Z, Liu Z, Liao L and Chen Y. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. The EMBO Journal. (2016) Feb 1;35(5):496-514.

12. Xu D*, Wang Z*, Zhang Y, Jiang W, Pan Y, Song B and Chen Y. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nature Communications. (2015) Aug 27;6:8100. (*co-first author)

13.Bian X*, Liu R*, Meng Y*, Xing D#Xu D# and Lu Z#Lipid metabolism and cancer. Journal of Experimental Medicine. (2021) Jan 4;218(1):e20201606. (*co-first author,#co-corresponding author)

14. Jiang H*, Zhu L*Xu Dand Lu Z#. A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis. Cancer Communications. (2020) Sep;40(9):389-394. (*co-first author,#co-corresponding author)