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成果及论文

主持或参加科研项目

1. 国家自然科学基金委员会,面上项目,22177066,乏氧/pH双重刺激响应型近红外荧光探针的构建及在肿瘤精准成像中的应用,2022/01-2025/12,在研,主持。

2. 陕西省科学技术厅,创新人才推进计划-青年科技新星项目,2021KJXX-51,基于pKa移动机理的生物硫醇半花菁类近红外荧光探针的构建及应用,2021/01-2022/12,在研,主持。

3. 秦巴生物资源与生态环境国培重点实验室(培育) “市校共建”科研专项项目,SXJ-2013,碳点基质稀土氨基酸配合物纳米复合材料抑菌性的量热学研究,2021/10-2024/09,在研,主持。

4. 陕西省科技厅自然科学基金项目,2019JQ006,硝基还原酶和溶酶体组分双控响应的荧光探针的构建及应用,2019/01-2020/12,结题,主持。

5. 陕西省教育厅自然科学研究专项项目,19JK0192,基于pKa移动机理构建荧光探针及其对硝基还原酶的检测,2019/01-2020/12,结题,主持。

6. 国家自然科学基金青年科学基金项目,21807068,基于碳点的生物硫醇纳米荧光探针的构建及应用,2019/01-2021/12,23.9 万元,在研,主持;

7. 国家自然科学基金青年科学基金项目,21605123,基于激光诱导击穿拉曼光谱技术的大气颗粒污染源解析化学计量学理论和方法研究,2017/01−2019/12,25万元,在研,第二参与人;

8. 陕西省科技厅青年项目,2019JQ060,具有线粒体靶向功能的比率型碳点基荧光纳米探针的构建和应用,2019/01-2020/12,3.0万元,在研,主持;

9. 陕西省教育厅项目,14JK1145,焦磷酸根离子复合荧光纳米探针的合成、机理及应用研究,2014/07-2015/12,2.0万元,结题,主持。

代表性研究成果

[1] Shengrui Zhang, Guojun Chen, Yuanyuan Wang, Qin Wang, Yaogang Zhong, Xiaofeng Yang,* Zheng Li, and Hua Li *, Far-Red fluorescent probe for imaging of vicinal dithiol-containing proteins in living cells based on a pKa shift mechanism. Analytical Chemistry, 2018, 90: 2946-2953.(SCI一区,影响因子8.008)

[2] Shengrui Zhang, Qin Wang, Xiawei Liu, Jianjian Zhang, Xiaofeng Yang*, Zheng Li, Hua Li *, Sensitive and selective fluorescent probe for selenol in living cells designed via a pKa shift strategy. Analytical Chemistry, 2018, 90 (6): 4119-4125.(SCI一区,影响因子8.008)

[3] Shengrui Zhang, Qin Wang, Jiajun Yang, Xiaofeng Yang *, Zheng Li, Hua Li*, A photocalibrated NO donor based on N-nitrosorhodamine 6G upon UV irradiation. Chinese Chemical Letters. 2019, 30: 454-456.(SCI二区,影响因子8.455)

[4] Shengrui Zhang, Qin Wang, Fangfang Wu, Jiajun Yang, Tianyi Cheng, Xiaofeng Yang*, Zheng Li, Hua Li*, Merocyanine-based turn-on for the sensitive and selective determination of thiophenols via a pKa shift mechanism. Talanta. 2020, 120965.(SCI二区,影响因子6.556)

[5] Shengrui Zhang, Xiaohui Ji, Jin Liu, Qin Wang *, Linxia Jin *, One-step synthesis of yellow-emissive carbon dots with a large Stokes shift and their application in fluorimetric imaging of intracellular pH. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2020, 227, 117677.(SCI二区,影响因子4.831)

[6] Qin Wang, Zhihua Tang, Lihua Li, Jinxiu Guo, Lingxia Jin, Jiufu Lu, Pei Huang, Shengrui Zhang*, and Long Jiao, Highly efficient red-emitting carbon dots as a “turn-on” temperature probe in living cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 280, 121538.(SCI二区,影响因子4.831)

[7] Shengrui Zhang, Linxia Jin, Jin Liu, Qin Wang *, Long Jiao *, A label-free yellow-emissive carbon dot-based nanosensor for sensitive and selective ratiometric detection of chromium (VI) in environmental water samples. Materials Chemistry and Physics, 2020, 248, 122912.(SCI三区,影响因子4.778)

[8] Shengrui Zhang, Haitao Yang, Xiaohui Ji, Qin Wang*. Binding analysis of carbon nanoparticles to human immunoglobulin G: Elucidation of the cytotoxicity of CNPs and perturbation of immunoglobulin conformations. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2016, 154: 33–41.(SCI二区,影响因子4.831)

[9] Shengrui Zhang, Huajie Wang, Yunyun Li, Fengkun Yang, Qin Wang *, Long Jiao*, Bright-yellow-emissive carbon dots with a large Stokes shift for selective fluorescent detection of 2, 4, 6-trinitrophenol in environmental water samples. Materials Letters, 2020, 263, 127208.(SCI三区,影响因子3.574)

[10] Shengrui Zhang*, Qin Wang, Zhifeng Liu, Jin Liu, Jiufu Lu. Carbon-dot-based colorimetric turn-on probe for selectively detecting thiophenols. Materials Letters 2020, 277, 128390.(SCI三区,影响因子3.574)

[11] Qin Wang, Shengrui Zhang, Yaogang Zhong, Xiaofeng Yang*, Li Zheng, Li Hua* (2016) Preparation of yellow-green-emissive carbon dots and their application in constructing a fluorescent turn-on nanoprobe for imaging of selenol in living cells. Analytical Chemistry, 89: 1734-1741.

[12] Qin Wang*, Shengrui Zhang, Hongguang Ge, Guanghui Tian, Nini Cao, Yaqin Li (2014) A fluorescent turn-off/on method based on carbon dots as fluorescent probes for the sensitive determination of Pb2+ and pyrophosphate in an aqueous solution. Sensors and Actuators B, 207: 25–33.



教学科研获奖

1. 强化植物修复重金属的重要措及快速检测机理研究, 陕西省人民政府, 陕西高等学校科学技术研究优秀成果奖, 一等奖, 2022年,(4/6)。

2. 第十一届汉中市自然科学优秀学术论文奖,二等奖,1/3,2018.

3 王芹(1/6),碳纳米材料在生命分析中的应用研究,陕西理工大学优秀科技成果奖(一等奖),2015. 07

4 王芹(1/3)黄绿色荧光碳点的制备及在构建细胞内硒醇纳米探针中的应用,汉中市自然科学优秀学术论文奖(一等奖),2018. 08