Interactions between the nervous and immune systems were recognized long ago, but recent studies show that this crosstalk occurs more frequently than was previously appreciated. Moreover, technological advances have enabled the identification of the molecular mediators and receptors that enable the interaction between these two complex systems and provide new insights on the role of neuroimmune crosstalk in organismal physiology. Most neuroimmune interactions occur at discrete anatomical locations in which neurons and immune cells colocalize. Here, we describe the interactions of the different branches of the peripheral nervous system with immune cells in various organs, including the skin, intestine, lung, and adipose tissue. We highlight how neuroimmune crosstalk orchestrates physiological processes such as host defense, tissue repair, metabolism, and thermogenesis. Unraveling these intricate relationships is invaluable to explore the therapeutic potential of neuroimmune interactions.

中文翻译：

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周围器官的神经免疫相互作用

神经系统和免疫系统之间的相互作用很久以前就被认识到了，但最近的研究表明，这种相互作用发生的频率比以前认识的要高。此外，技术进步使得能够识别分子介质和受体，从而实现这两个复杂系统之间的相互作用，并为神经免疫串扰在生物体生理学中的作用提供新的见解。大多数神经免疫相互作用发生在神经元和免疫细胞共定位的离散解剖位置。在这里，我们描述了周围神经系统不同分支与各种器官（包括皮肤、肠道、肺和脂肪组织）中免疫细胞的相互作用。我们重点介绍神经免疫串扰如何协调宿主防御、组织修复、新陈代谢和产热等生理过程。阐明这些错综复杂的关系对于探索神经免疫相互作用的治疗潜力非常有价值。