Nervous system activity regulates development, homeostasis, and plasticity of the brain as well as other organs in the body. These mechanisms are subverted in cancer to propel malignant growth. In turn, cancers modulate neural structure and function to augment growth-promoting neural signaling in the tumor microenvironment. Approaching cancer biology from a neuroscience perspective will elucidate new therapeutic strategies for presently lethal forms of cancer. In this review, we highlight the neural signaling mechanisms recapitulated in primary brain tumors, brain metastases, and solid tumors throughout the body that regulate cancer progression.

中文翻译：

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癌症中的神经信号传导

神经系统活动调节大脑以及身体其他器官的发育、体内平衡和可塑性。这些机制在癌症中被破坏，从而促进恶性生长。反过来，癌症调节神经结构和功能，以增强肿瘤微环境中促进生长的神经信号传导。从神经科学的角度研究癌症生物学将阐明目前致命癌症的新治疗策略。在这篇综述中，我们重点介绍了原发性脑肿瘤、脑转移瘤和全身实体瘤中调节癌症进展的神经信号机制。