It has been clarified that pathogens bind to glycosphingolipid (GSL) receptors in mammals, but there have been very few reports on pathogen-binding GSLs in fish. Vibrios are facultative anaerobic bacteria ubiquitous in marine and brackish environments. They are members of the normal intestinal microflora of healthy fish, but some species can cause a disease called vibriosis in fish and shellfish when the hosts are physiologically or immunologically weakened. The adherence of vibrios to host intestinal tracts is a significant event not only for survival and growth but also in terms of pathogenicity. We show in this mini-review that sialic acid-containing GSLs (gangliosides), GM4 and GM3, are receptors to which vibrios adhere to epithelial cells in the intestinal tract of fish. We also describe the enzymes responsible for synthesizing these Vibrio-binding gangliosides in fish.

已经阐明病原体与哺乳动物体内的糖鞘脂（GSL）受体结合，但鲜有关于鱼类病原体结合GSLs的报道。弧菌是兼性厌氧菌，普遍存在于海洋和咸水环境中。它们是健康鱼类正常肠道微生物群落的成员，但当宿主生理或免疫力减弱时，某些物种会在鱼类和贝类中引起一种称为弧菌病的疾病。弧菌对宿主肠道的粘附不仅对于生存和生长而且在致病性方面都是一个重要事件。我们在这篇小型综述中表明，含唾液酸的 GSL（神经节苷脂）、GM4 和 GM3 是弧菌附着在鱼类肠道上皮细胞上的受体。我们还描述了负责合成这些的酶鱼中结合弧菌的神经节苷脂。