After tissue damage, a series of molecular and cellular events are initiated to promote tissue repair and regeneration to restore its original structure and function. These events include inter-cell communication, cell proliferation, cell migration, extracellular matrix differentiation, and other critical biological processes. Glycosylation is the crucial conservative and universal post-translational modification in all eukaryotic cells [1], with influential roles in intercellular recognition, regulation, signaling, immune response, cellular transformation, and disease development. Studies have shown that abnormally glycosylation of proteins is a well-recognized feature of cancer cells, and specific glycan structures are considered markers of tumor development. There are many studies on gene expression and regulation during tissue repair and regeneration. Still, there needs to be more knowledge of complex carbohydrates’ effects on tissue repair and regeneration, such as glycosylation. Here, we present a review of studies investigating protein glycosylation in the tissue repair and regeneration process.

组织损伤后，启动一系列分子和细胞事件，促进组织修复和再生，恢复其原有的结构和功能。这些事件包括细胞间通讯、细胞增殖、细胞迁移、细胞外基质分化和其他关键生物过程。糖基化是所有真核细胞中重要的保守和普遍的翻译后修饰 [1]，在细胞间识别、调节、信号传导、免疫反应、细胞转化和疾病发展中具有重要作用。研究表明，蛋白质的异常糖基化是癌细胞公认的特征，特定的聚糖结构被认为是肿瘤发展的标志。关于组织修复和再生过程中基因表达和调控的研究较多。尽管如此，仍需要更多地了解复合碳水化合物对组织修复和再生的影响，例如糖基化。在这里，我们回顾了研究组织修复和再生过程中蛋白质糖基化的研究。