Compounds containing triazole have many significant applications in the dye and ink industry, corrosion inhibitors, polymers, and pharmaceutical industries. These compounds possess many antimicrobial, antioxidant, anticancer, antiviral, anti-HIV, antitubercular, and anticancer ac-tivities. Several synthetic methods have been reported for reducing time, minimizing synthetic steps, and utilizing less hazardous and toxic solvents and reagents to improve the yield of triazoles and their analogues synthesis. Among the improvement in methods, green approaches towards tri-azole forming biologically active compounds, especially anticancer compounds, would be very important for pharmaceutical industries as well as global research community. In this article, we have reviewed the last five years of green chemistry approaches on click reaction between alkyl azide and alkynes to install 1,2,3-triazole moiety in natural products and synthetic drug-like mole-cules, such as in colchicine, flavanone cardanol, bisphosphonates, thiabendazoles, piperazine, prostanoid, flavonoid, quinoxalines, C-azanucleoside, dibenzylamine, and aryl-azotriazole. The cytotoxicity of triazole hybrid analogues was evaluated against a panel of cancer cell lines, includ-ing multidrug-resistant cell lines.

中文翻译：

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用于开发抗癌药物的三唑形成反应的绿色方法

含有三唑的化合物在染料和油墨工业、缓蚀剂、聚合物和制药工业中具有许多重要的应用。这些化合物具有许多抗菌、抗氧化、抗癌、抗病毒、抗艾滋病毒、抗结核和抗癌活性。已经报道了几种合成方法，可以减少时间、最大限度地减少合成步骤，并使用危险和毒性较小的溶剂和试剂来提高三唑及其类似物合成的产率。在方法的改进中，三唑形成生物活性化合物，特别是抗癌化合物的绿色方法对于制药行业以及全球研究界将非常重要。在本文中，我们回顾了过去五年关于烷基叠氮化物和炔烃之间的点击反应以在天然产物和合成药物样分子中安装1,2,3-三唑部分的绿色化学方法，例如秋水仙碱，黄烷酮腰果酚、双膦酸盐、噻菌灵、哌嗪、前列腺素、类黄酮、喹喔啉、C-氮杂核苷、二苄胺和芳基偶氮三唑。针对一组癌细胞系（包括多重耐药细胞系）评估了三唑杂合类似物的细胞毒性。