Since its discovery at the beginning of the 20th century, trifluoroacetic acid, commonly known as TFA, has seen extensive application in organic synthesis both as a solvent and as a catalyst/ reagent. TFA can be used to facilitate a wide variety of chemical transformations, including rearrangements, functional group deprotections, condensations, hydroarylations and trifluoroalkylations, among others. The decennial mini-review examines key TFA synthetic applications from the middle of 2013 to the present, providing the organic chemistry research community with an opportunity to delve deeply into the numerous and varied applications of this strong acid, water-miscible, and low boiling point reagent.

中文翻译：

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三氟乙酸应用十年更新

自 20 世纪初发现以来，三氟乙酸（俗称 TFA）在有机合成中作为溶剂和催化剂/试剂得到了广泛的应用。TFA 可用于促进多种化学转化，包括重排、官能团脱保护、缩合、加氢芳基化和三氟烷基化等。十年一次的小型回顾审查了从 2013 年中至今的关键 TFA 合成应用，为有机化学研究界提供了深入研究这种强酸、水混溶性和低沸点的众多不同应用的机会试剂。