The synthesis of 1-cyanoacetylthiosemicarbazides is at the apex attention of researchers due to their multifaced reactivity as versatile precursors in the synthesis of mono-, bi-, and fused_heterocyclic compounds as well as metal complexes. Despite this, no comprehensive survey was, so far, dedicated to the synthesis, chemical transformation, and bioactivities of this relevant family of synthetic organic precursors and their derivatives. The present survey aims to summarize an up-to-date record of the preparation of 1-cyanoacetylthiosemicarbazides and their chemical transformation. A particular focus is given to their metal complexes and bio-applications

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1-氰乙酰氨基硫脲：其合成、杂环化反应性和生物应用的最新进展

1-氰基乙酰氨基硫脲的合成因其多方面的反应性而受到研究人员的高度关注，作为合成单环、双环和稠合杂环化合物以及金属络合物的多功能前体。尽管如此，迄今为止，还没有专门针对这一相关合成有机前体家族及其衍生物的合成、化学转化和生物活性的全面调查。本调查旨在总结 1-氰基乙酰氨基硫脲的制备及其化学转化的最新记录。特别关注其金属配合物和生物应用