Abstract

The kinetics of elongation of nucleic acids as a multistep sequential reaction forming a cycle was studied. A mathematically rigorous proof was given for the empirical formulas used to estimate the elongation time as a function of the length of the nucleotide chain. Estimates of the characteristic elongation time for typical chain lengths were proposed, including for the novel coronavirus (SARS-CoV-2). The stability of the elongation kinetics was investigated, and it was determined that, at typical chain lengths, increasing-amplitude unstable oscillating components appear along with the main exponential component.

中文翻译：

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作为多步顺序酶促反应的核酸延伸的动力学特征

摘要

研究了作为形成循环的多步连续反应的核酸延伸的动力学。对于用于估计作为核苷酸链长度函数的延伸时间的经验公式，给出了数学上严格的证明。提出了对典型链长的特征延伸时间的估计，包括新型冠状病毒 (SARS-CoV-2)。对伸长动力学的稳定性进行了研究，并确定在典型的链长度下，随着主要指数分量出现幅度增加的不稳定振荡​​分量。