Abstract

Bacterial transmission is considered one of the potential risks for communicable diseases. Nanotechnology could be beneficial in managing bacterial issues particularly. Based on their distinct physiochemical characteristics, the extraordinary antimicrobial effects of metal nanoparticles (NPs) offer such structures suitable for use both in vitro and in vivo as self-modified therapeutic agents. Due to their wide range of antimicrobial efficacy, diverse antimicrobial routes, and good biocompatibility, NPs have potential therapeutic aplication prospects. NPS restricts the establishment of bacterial resistance and broadens the scope of antimicrobial activity without binding with the bacterial cell to a particular receptor. As a result, several efficacy experiments on metal-based NPS published so far have promising findings on both Gram-positive and Gram-negative bacteria. This review is aimed to explore the most relevant types of metal NPs employed as antimicrobial agents, particularly those based on the Mn, Fe, Co, Cu, Ag, and Zn-based NPs, and to highlight their antimicrobial mechanisms.

中文翻译：

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过渡金属基纳米粒子作为潜在的抗菌剂

摘要

细菌传播被认为是传染病的潜在风险之一。纳米技术尤其有利于管理细菌问题。基于其独特的理化特性，金属纳米粒子（NP）非凡的抗菌作用提供了适合在体外和体内用作自修饰治疗剂的结构。纳米颗粒由于其广泛的抗菌功效、多样的抗菌途径和良好的生物相容性，具有潜在的治疗应用前景。NPS 限制细菌耐药性的建立并扩大抗菌活性的范围，而不与细菌细胞与特定受体结合。因此，迄今为止发表的几项基于金属的 NPS 功效实验在革兰氏阳性和革兰氏阴性细菌上都取得了有希望的结果。本综述旨在探索用作抗菌剂的最相关的金属纳米颗粒类型，特别是那些基于锰、铁、钴、铜、银和锌的纳米颗粒，并强调它们的抗菌机制。