Three new halimane furanoditerpenoids (1–3) and three new clerodane furanoditerpenoids (4–6), along with seven known terpenoids including four pimarane diterpenoids (7–10) and three norisoprenoids (11–13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1–6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC₅₀ values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.

Graphical Abstract

中文翻译：

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巴豆蛇床子中新的卤烷和氯烷二萜类化合物

从 95% EtOH 提取物中分离出三种新的卤烷呋喃二萜 ( 1 – 3 ) 和三种新的克罗丹呋喃二萜 ( 4 – 6 ) 以及七种已知的萜类化合物，包括四种螺环二萜 ( 7 – 10 ) 和三种降异戊二烯 ( 11 – 13 )巴豆 cnidophyllus植物。通过分析 HRMS 和 NMR 数据以及实验和计算的 ECD 曲线的比较，阐明了新呋喃二萜 ( 1 – 6 )的二维结构，包括绝对构型。生物测定显示两种化合物（8和9 )对LPS刺激的NO产生具有一定的抑制作用，IC ₅₀值分别为19.00±1.76和21.61±1.11μM。

图形概要