Background

Lipid metabolism is considerably complex and there can be many critical steps in atherogenesis. The association between lysosomal acid lipase (LAL) activity and coronary artery disease (CAD) has not been elucidated in detail. We aimed to evaluate the association between LAL activity with the presence and severity of CAD in patients who are seen in daily clinical practice.

Methods

Patients who underwent coronary angiography were divided into groups according to the angiography results. Syntax scores and Gensini scores were calculated. The LAL activity was measured from dried blood spots.

Results

Median LAL activity values were similar in all study groups (normal coronary arteries: 0.40 nmol/punch/h; non-obstructive CAD: 0.44 nmol/punch/h; obstructive chronic CAD: 0.40 nmol/punch/h; obstructive acute coronary syndrome: 0.48 nmol/punch/h) and there was no correlation between coronary atherosclerotic burden and LAL activity (correlation coefficients Syntax score and LAL: −0.032; Gensini score and LAL: −0.030). In addition, no relationship between serum lipid levels and LAL activity was detected.

Conclusion

The presence of CAD and its severity is not associated with the LAL activity in patients encountered in daily clinical practice.

中文翻译：

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溶酶体酸性脂肪酶活性与冠状动脉疾病的存在和严重程度相关吗？

背景

脂质代谢相当复杂，动脉粥样硬化形成中有许多关键步骤。溶酶体酸性脂肪酶 (LAL) 活性与冠状动脉疾病 (CAD) 之间的关联尚未详细阐明。我们的目的是评估日常临床实践中患者的 LAL 活性与 CAD 的存在及其严重程度之间的关联。

方法

接受冠状动脉造影的患者根据血管造影结果进行分组。计算语法分数和 Gensini 分数。鲎试剂的活性是通过干燥的血斑来测量的。

结果

所有研究组的中位 LAL 活性值相似（正常冠状动脉：0.40 nmol/punch/h；非阻塞性 CAD：0.44 nmol/punch/h；阻塞性慢性 CAD：0.40 nmol/punch/h；阻塞性急性冠状动脉综合征： 0.48 nmol/punch/h），冠状动脉粥样硬化负荷与 LAL 活性之间不存在相关性（相关系数 Syntax 评分和 LAL：-0.032；Gensini 评分和 LAL：-0.030）。此外，未检测到血清脂质水平与 LAL 活性之间的关系。

结论

CAD 的存在及其严重程度与日常临床实践中遇到的患者的 LAL 活性无关。