Six new naphthoquinones, euchronin A–F (1–6) and nine known naphthoquinones (7–15), were isolated from the roots of Arnebia euchroma (Royle) Johnst. The structures of the new compounds were confirmed by extensive spectroscopic analyses, including UV, IR, HR-ESI–MS, 1D and 2D NMR. In the present study, we estimated the anti-proliferative activities of these compounds with HaCaT cells. The results indicated that compounds 2 and 4 showed strong anti-proliferative activities at 25 μM, with relative viability at 38.83% and 68.44%, respectively.

Graphical Abstract

中文翻译：

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从 Arnebia euchroma (Royle) Johnst 中分离出 Euchronin A–F。及其体外抗增殖活性

从Arnebia euchroma (Royle) Johnst的根中分离出六种新的萘醌，euchronin A–F ( 1 – 6 ) 和九种已知的萘醌 ( 7 – 15 ) 。新化合物的结构通过广泛的光谱分析得到证实，包括紫外、红外、HR-ESI-MS、一维和二维核磁共振。在本研究中，我们评估了这些化合物对 HaCaT 细胞的抗增殖活性。结果表明，化合物2和4在25 μM浓度下表现出较强的抗增殖活性，相对活力分别为38.83%和68.44%。

图形概要