This study investigated the effects of dynamic resistance exercise (DRE), isometric handgrip exercise (IHE) and combined resistance exercise (DRE+IHE) on post-exercise hypotension (PEH) and its hemodynamic, autonomic, and vascular mechanisms. For that, 70 medicated hypertensives men (52 ± 8 years) were randomly allocated to perform one of the following interventions: DRE (3 sets, 8 exercises, 50% of 1RM), IHE (4 sets, 2 min, 30% of MVC), CRE (DRE+IHE) and control (CON, seated rest). Before and after the interventions, blood pressure (BP), systemic hemodynamics, cardiovascular autonomic modulation and brachial vascular parameters were evaluated. After the DRE and CRE, systolic and mean BP decreased (SBP = −7 ± 6 and −8 ± 8 mmHg; MBP −4 ± 5 and −5 ± 5 mmHg, respectively, all P < 0.05), vascular conductance increased (+ 0.47 ± 0.61 and +0.40 ± 0.47 ml.min⁻¹.mmHg⁻¹, respectively, both P < 0.05) and baroreflex sensitivity decreased (−0.15 ± 0.38 and −0.29 ± 0.47 ms/mmHg, respectively, both P < 0.05) in comparison to pre-exercise values. No variable presented any significant change after IHE. The responses observed after CRE were similar to DRE and significantly different from CON and IHE. In conclusion, DRE, but not IHE, elicits PEH, which happens concomitantly to skeletal muscle vasodilation and decreased baroreflex sensitivity. Moreover, adding IHE to DRE does not potentiate PEH and neither changes its mechanisms.

Clinical Trial Registration: Data from this study derived from an ongoing longitudinal clinical trial approved by the Institution’s Ethics Committee of Human Research (process 2.870.688) and registered at the Brazilian Clinical Trials (RBR-4fgknb) at http://www.ensaiosclinicos.gov.br.

本研究探讨了动态阻力运动（DRE）、等长握力运动（IHE）和联合阻力运动（DRE+IHE）对运动后低血压（PEH）的影响及其血流动力学、自主神经和血管机制。为此，70 名药物高血压男性（52 ± 8 岁）被随机分配进行以下干预措施之一：DRE（3 组，8 次练习，1RM 的 50%）、IHE（4 组，2 分钟，MVC 的 30%） ）、CRE（DRE+IHE）和控制（CON，坐姿休息）。干预前后评估血压（BP）、全身血流动力学、心血管自主调节和肱血管参数。DRE和CRE后，收缩压和平均血压下降（SBP分别为-7 ± 6和-8 ± 8 mmHg；MBP分别为-4 ± 5和-5 ± 5 mmHg，所有P < 0.05），血管电导增加（  +分别为 0.47 ± 0.61 和 +0.40 ± 0.47 ml.min ⁻¹ .mmHg ⁻¹，均P  < 0.05）和压力反射敏感性下降（分别为 −0.15 ± 0.38 和 −0.29 ± 0.47 ms/mmHg，均P  < 0.05）与运动前的值进行比较。IHE 后没有变量出现任何显着变化。CRE 后观察到的反应与 DRE 相似，但与 CON 和 IHE 显着不同。总之，DRE（而非 IHE）会引发 PEH，而 PEH 会伴随骨骼肌血管舒张和压力感受反射敏感性降低而发生。此外，在 DRE 中添加 IHE 不会增强 PEH，也不会改变其机制。

临床试验注册：本研究的数据来自一项正在进行的纵向临床试验，该试验经该机构人类研究伦理委员会批准（流程 2.870.688），并在巴西临床试验 (RBR-4fgknb) 注册，网址为：http://www.ensaiosclinicos .gov.br。