Ischemic stroke is a leading cause of disability and death in patients. Despite considerable recent advances in the treatment of ischemic stroke, only a limited number of effective neuroprotective agents are available for stroke. Green tea (Camellia sinensis) is a popular herbal plant, and numerous studies have indicated its health benefits for several diseases. Green tea is of interest due to its high content of catechin derivatives, including epicatechin, gallocatechin, epicatechin gallate, epigallocatechin, and epigallocatechin-3-gallate. This review tried to develop a feasible background for the potential effects of green tea and its bioactive derivatives concerning protection against ischemic stroke. Green tea’s antioxidants, anti-inflammatory, anti-apoptotic, and neuroprotective effects are believed to be efficacious in stroke treatment. Evidence supports the idea that green tea can be used to assist in treating ischemic stroke.

Graphical Abstract

Green tea has a protective effect against ischemic stroke; Epigallocatechin-3-gallate: EGCG, Epicatechin: EC, Gallocatechin gallate: GCG, Epigallocatechin: EGC, Epicatechin gallate: ECG, Catechin: C, Gallocatechin: GC.

中文翻译：

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绿茶（Camellia sinensis）治疗缺血性中风的潜力：生化和分子证据

缺血性中风是患者残疾和死亡的主要原因。尽管最近在治疗缺血性中风方面取得了相当大的进展，但只有有限数量的有效神经保护剂可用于中风。绿茶（Camellia sinensis）是一种受欢迎的草药植物，大量研究表明它对多种疾病有益。绿茶因其高含量的儿茶素衍生物而受到关注，包括表儿茶素、没食子儿茶素、表儿茶素没食子酸酯、表没食子儿茶素和表没食子儿茶素-3-没食子酸酯。本综述试图为绿茶及其生物活性衍生物在预防缺血性中风方面的潜在作用建立一个可行的背景。绿茶的抗氧化、抗炎、抗细胞凋亡和神经保护作用被认为对中风治疗有效。有证据支持绿茶可用于辅助治疗缺血性中风的观点。

图形概要

绿茶对缺血性中风有保护作用；表没食子儿茶素-3-没食子酸酯：EGCG、表儿茶素：EC、没食子儿茶素没食子酸酯：GCG、表没食子儿茶素：EGC、表儿茶素没食子酸酯：ECG、儿茶素：C、没食子儿茶素：GC。