Background

Regular brushing is the most popular oral hygiene technique and using additional interdental cleaning tools like dental floss and oral rinse (OR) is advised. The objective of this study was to examine the efficacy of ORs containing 0.045% cetylpyridinium chloride (CPC) on oral health-related parameters in a 4-week-long double-blinded and randomized clinical trial.

Methods

Seventy-four subjects were assigned to four groups: two control groups that used non-CPC-containing ORs (C1 [n = 20], C2 [n = 19]) and two groups that used CPC-containing ORs (immediate-use CPC [IUC] [n = 16], concentrated-use CPC [CUC] [n = 19]). The subjects were instructed to gargle with 20 mL of the ORs for 30 s after brushing their teeth thrice a day for 4 weeks. There was a substantial decrease in the levels of volatile sulfur compounds after the use of the ORs.

Results

The Turesky modification of the Quigley–Hein Plaque Index and Löe and Silness Gingival Index showed a decreasing trend after the intervention, but not at a significant level. The Tongue Coating Index also showed a decrease in the intervention groups, but not in the control groups. Surprisingly, in both formulations, the inclusion of CPC in OR dramatically decreased the growth of aerobic bacteria in the mouth by expressed CFU/mL in both treatment groups.

Conclusion

CPC-containing ORs can be recommended as an adjunct to the standard home care routine in promoting oral health.

Clinical trial registration

NCT05644236.

中文翻译：

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含有氯化十六烷基吡啶的漱口水对口腔健康的影响：一项随机临床试验

背景

定期刷牙是最流行的口腔卫生技术，建议使用牙线和漱口水 (OR) 等额外的齿间清洁工具。本研究的目的是在为期 4 周的双盲随机临床试验中检验含有 0.045% 氯化十六烷基吡啶 (CPC) 的 OR 对口腔健康相关参数的功效。

方法

74 名受试者被分配到四组：两个使用不含 CPC OR 的对照组（C1 [ n  = 20]、C2 [ n  = 19]）和两个使用含 CPC OR 的组（立即使用 CPC） [IUC] [ n  = 16]，浓缩使用 CPC [CUC] [ n  = 19]）。受试者每天刷牙三次，持续 4 周，然后被指示用 20 mL 的 OR 漱口 30 秒。使用 OR 后，挥发性硫化合物的水平大幅下降。

结果

Turesky 修正的 Quigley-Hein 牙菌斑指数以及 Loe 和 Silness 牙龈指数在干预后呈现下降趋势，但并未达到显着水平。干预组的舌苔指数也有所下降，但对照组则没有下降。令人惊讶的是，在两种配方中，在 OR 中添加 CPC 都显着降低了口腔中需氧细菌的生长（在两个治疗组中均以 CFU/mL 表示）。

结论

含 CPC 的 OR 可以被推荐作为标准家庭护理常规的辅助手段，以促进口腔健康。

临床试验注册

NCT05644236。