Therapeutic and diagnostic progresses have significantly reduced the mortality rate among cancer patients during the last decade. However, there is still a high rate of mortality among cancer patients. One of the important reasons involved in the high mortality rate is the late diagnosis in advanced tumor stages that causes the failure of therapeutic strategies in these patients. Therefore, investigating the molecular mechanisms involved in tumor progression has an important role in introducing the efficient early detection markers. MicroRNAs (miRNAs) as stable factors in body fluids are always considered as non-invasive diagnostic and prognostic markers. In the present review, we investigated the role of miR-495 in tumor progression. It has been reported that miR-495 has mainly a tumor suppressor function through the regulation of transcription factors and tyrosine kinases as well as cellular processes such as multidrug resistance, chromatin remodeling, and signaling pathways. This review can be an effective step towards introducing the miR-495 as a non-invasive diagnostic/prognostic marker as well as a suitable target in tumor therapy.

过去十年中，治疗和诊断的进步显着降低了癌症患者的死亡率。然而，癌症患者的死亡率仍然很高。造成高死亡率的重要原因之一是肿瘤晚期诊断较晚，导致这些患者的治疗策略失败。因此，研究肿瘤进展的分子机制对于引入有效的早期检测标志物具有重要作用。MicroRNA（miRNA）作为体液中的稳定因子一直被认为是非侵入性诊断和预后标志物。在本综述中，我们研究了 miR-495 在肿瘤进展中的作用。据报道，miR-495主要通过调节转录因子和酪氨酸激酶以及多药耐药、染色质重塑和信号通路等细胞过程发挥抑癌功能。此次综述可能是将 miR-495 作为非侵入性诊断/预后标志物以及肿瘤治疗的合适靶点引入的有效步骤。