Abstract

A final review of the results of studies of versatile biological activities (in vitro) of chiral metal complexes with benzylamine and ethylenediamine derivatives of terpenes is presented. The cytotoxic profiles of palladacycles containing a Pd–C bond and palladium and zinc chelate complexes were determined. For a number of compounds, the possible mechanisms of potential anticancer action were analyzed, such as modulation of mitochondrial functioning and effect on the parameters of glycolytic function of tumor cells. The antibacterial and antifungal activities of palladium complexes of different types and copper chelate complexes were investigated. A correlation between high antimicrobial activity and antioxidant properties was found for a number of copper complexes. The material is supplemented by an extended analysis of publications in relevant subjects.

中文翻译：

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具有生物活性的钯 (II)、锌 (II) 和铜 (II) 与萜烯配体的配合物作为潜在的药物

摘要

对萜烯苯甲胺和乙二胺衍生物的手性金属配合物的多功能生物活性（体外）研究结果进行了最终综述。测定了含有 Pd-C 键以及钯和锌螯合物的钯环的细胞毒性特征。对于许多化合物，分析了潜在抗癌作用的可能机制，例如线粒体功能的调节和对肿瘤细胞糖酵解功能参数的影响。研究了不同类型的钯配合物和铜螯合物的抗菌和抗真菌活性。发现许多铜络合物的高抗菌活性和抗氧化特性之间存在相关性。