Abstract

The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.

中文翻译：

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WGR 域在 PARP1 和 PARP2 功能中的作用

摘要

PARP1 和 PARP2 蛋白是聚（ADP-核糖）聚合酶家族的成员，参与 DNA 修复和复制、RNA 加工、核糖体生物发生、转录、细胞分裂和细胞死亡的调节。PARP1和PARP2是开发抗癌药物的有希望的靶标，可用于治疗心血管、神经退行性疾病和其他疾病。WGR 结构域已被证明在 PARP1 和 PARP2 蛋白的功能中发挥着核心作用。这篇综述考虑了 PARP1 和 PARP2 蛋白中 WGR 结构域的功能机制，它们具有一些相似和特殊的特性。了解这些过程对基础科学具有重大意义，并且有助于开发更有效和选择性的 PARP1 和 PARP2 抑制剂。