Purpose

We aimed to examine the association between hypertension grades and the risk of total and site-specific cancer mortality among Japanese men and women.

Methods

In the Japan Collaborative Cohort Study, 27,332 participants aged 40–79 years were enrolled and followed up with their mortality until 2009. According to the measured blood pressure (BP) at baseline, we classified the participants into four BP categories based on 2018 European guidelines. The Cox proportional hazard models were used to calculate the multivariable hazard ratios (HRs) with 95% confidence intervals (CIs) of total and site-specific cancer mortality according to the hypertension category.

Results

During the 18.5 years of median follow-up, 1,927 cancer deaths were documented. Grade 1 (systolic blood pressure [SBP] 140–159 mmHg or diastolic blood pressure [DBP] 90–99 mmHg) and grade 2–3 hypertension (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg) were associated with an increased risk of total cancer mortality; the multivariable HRs were 1.17 (1.04–1.32) for grade 1, and 1.27 (1.09–1.47) for grade 2–3 hypertension compared to optimal and normal BP (SBP < 130 mmHg and DBP < 85 mmHg). Linear and positive associations were observed between SBP and DBP 10 mmHg increment and the risk of total cancer mortality; HRs were 1.06 (1.03–1.08) for SBP and 1.07 (1.02–1.11) for DBP of 10 mmHg increment. The excess risk was primarily found for esophageal, liver, and pancreatic cancer; the respective multivariable HRs of grade 2–3 hypertension vs optimal and normal BP were 2.57 (1.10–6.04) for esophageal, 1.67 (1.01–2.77) for liver, and 1.95 (1.17–3.23) for pancreatic cancer.

Conclusion

Hypertension was associated with the increased risk of total cancer mortality, primarily of esophageal, liver, and pancreatic cancer.

中文翻译：

---

日本男性和女性的高血压等级与癌症死亡率之间的关联

目的

我们的目的是研究日本男性和女性的高血压等级与总体和特定部位癌症死亡率之间的关系。

方法

在日本协作队列研究中，招募了 27,332 名 40-79 岁的参与者，并随访其死亡率直至 2009 年。根据基线测量的血压 (BP)，我们根据 2018 年欧洲指南将参与者分为四个血压类别。 Cox 比例风险模型用于根据高血压类别计算总癌症死亡率和特定部位癌症死亡率的多变量风险比 (HR) 和 95% 置信区间 (CI)。

结果

在中位随访 18.5 年期间，记录了 1,927 例癌症死亡病例。 1 级（收缩压 [SBP] 140–159 mmHg 或舒张压 [DBP] 90–99 mmHg）和 2–3 级高血压（SBP ≥ 160 mmHg 或 DBP ≥ 100 mmHg）与总体风险增加相关。癌症死亡率；与最佳血压和正常血压（收缩压<130毫米汞柱和舒张压<85毫米汞柱）相比，1级高血压的多变量HR为1.17（1.04-1.32），2-3级高血压的多变量HR为1.27（1.09-1.47）。收缩压和舒张压增加 10 毫米汞柱与总癌症死亡率之间存在线性和正相关关系；增量为 10 mmHg 时，SBP 的 HR 为 1.06 (1.03–1.08)，DBP 的 HR 为 1.07 (1.02–1.11)。过高的风险主要存在于食管癌、肝癌和胰腺癌； 2-3级高血压与最佳血压和正常血压的多变量HR分别为，食管癌为2.57（1.10-6.04），肝癌为1.67（1.01-2.77），胰腺癌为1.95（1.17-3.23）。

结论

高血压与癌症总死亡率（主要是食管癌、肝癌和胰腺癌）的风险增加有关。