One of the key objectives of regenerative medicine is the design of skin tissue engineering scaffolds to promote wound healing. These scaffolds provide a fresh viewpoint on skin injury repair by emulating body tissues in their structure. A suitable platform for cellular processes can be provided by natural scaffolds made from decellularized tissues while retaining the primary components. Resveratrol (RES), which has qualities like angiogenesis, antioxidant, antibacterial, and anti-inflammatory, is also useful in the healing of wounds. In this investigation, RES-loaded decellularized sheep pericardium scaffolds were created and tested on full-thickness wounds in a mouse model. According to the in vivo findings, the groups in which the wound was treated with decellularized pericardium (DP) had better wound healing than the control group and showed more production of angiogenic and anti-inflammatory substances. The secretion of these factors was greater in RES‐loaded decellularized pericardium (DP-RES) than in the scaffold without RES, and the macroscopic and histological data supported this. Therefore, the use of decellularization scaffolds with substances like RES for the regeneration of skin wounds can be further researched and evaluated in the preclinical stages.

再生医学的关键目标之一是设计皮肤组织工程支架以促进伤口愈合。这些支架通过模拟身体组织的结构，为皮肤损伤修复提供了新的视角。由脱细胞组织制成的天然支架可以为细胞过程提供合适的平台，同时保留主要成分。白藜芦醇 (RES) 具有血管生成、抗氧化、抗菌和抗炎等功效，也可用于伤口愈合。在这项研究中，创建了负载 RES 的脱细胞羊心包支架，并在小鼠模型的全层伤口上进行了测试。根据体内研究结果，用脱细胞心包（DP）处理伤口的组比对照组有更好的伤口愈合，并且显示出更多的血管生成和抗炎物质的产生。这些因子的分泌在负载RES的脱细胞心包（DP-RES）中比在没有RES的支架中更多，并且宏观和组织学数据支持了这一点。因此，使用含有RES等物质的脱细胞支架来再生皮肤伤口可以在临床前阶段进一步研究和评估。