Tubercidin is an adenosine analogue that has been shown to exhibit good activity against some tumours and parasites. In this study, the in vitro activity of tubercidin was evaluated against Mycobacterium tuberculosis (Mtb) and nontuberculosis Mycobacteria (NTM). For determining the MICs of tubercidin, 23 fully drug-sensitive (DS) Mtb strains, 33 multi-drug resistance tuberculosis (MDR-TB) strains, 29 pre-extensively drug-resistant tuberculosis (pre-XDR-TB) strains, 21 extensively drug-resistant tuberculosis (XDR-TB) strains, 17 rapidly growing mycobacteria (RGM) and nine slowly growing mycobacteria (SGM) references strains were tested by microplate-based Alamar Blue assay (MABA) method. The results indicate that tubercidin has high in vitro activity against some drug-resistance Mtb strains and NTM reference strains, which warrants further investigation on the actions of tubercidin and its derivatives as potential drugs for mycobacterial infections.

中文翻译：

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结核菌素对结核分枝杆菌和非结核分枝杆菌的体外活性

结核菌素是一种腺苷类似物，已被证明对某些肿瘤和寄生虫具有良好的活性。在这项研究中，评估了结核菌素针对结核分枝杆菌(Mtb) 和非结核分枝杆菌 (NTM) 的体外活性。为了确定结核菌素的 MIC，23 种完全药物敏感 (DS) 结核分枝杆菌菌株、33 种多重耐药结核 (MDR-TB) 菌株、29 种前广泛耐药结核 (pre-XDR-TB) 菌株、21 种广泛耐药结核菌株采用基于微孔板的 Alamar Blue 测定 (MABA) 方法测试了耐药结核病 (XDR-TB) 菌株、17 种快速生长的分枝杆菌 (RGM) 和 9 种缓慢生长的分枝杆菌 (SGM) 参考菌株。结果表明，结核菌素对一些耐药Mtb菌株和NTM参考菌株具有较高的体外活性，值得进一步研究结核菌素及其衍生物作为分枝杆菌感染潜在药物的作用。