Addiction is a leading cause of disease burden worldwide and remains a challenge in current neuroscience research. Drug-induced lasting changes in gene expression are mediated by transcriptional and epigenetic regulation in the brain and are thought to underlie behavioral adaptations. Emerging evidence implicates astrocytes in regulating drug-seeking behaviors and demonstrates robust transcriptional response to several substances of abuse. This review focuses on the astrocytic transcriptional and epigenetic mechanisms of drug action.

中文翻译：

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药物成瘾的星形胶质细胞转录和表观遗传机制

成瘾是全世界疾病负担的主要原因，并且仍然是当前神经科学研究的一个挑战。药物引起的基因表达的持久变化是由大脑中的转录和表观遗传调节介导的，并且被认为是行为适应的基础。新的证据表明星形胶质细胞参与调节药物寻求行为，并显示出对几种滥用药物的强大转录反应。本综述重点关注药物作用的星形细胞转录和表观遗传机制。